The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Novel insights of dietary polyphenols and obesity
Open accessAbstract
Prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of dietary polyphenols in the prevention of obesity and obesity-related chronic diseases. Here we evaluated the impact of commonly consumed polyphenols, including green tea catechins and epigallocatechin gallates, resveratrol, and curcumin, on obesity and obesity-related-inflammation. Cellular studies demonstrated that these dietary polyphenols reduce viability of adipocytes and proliferation of preadipocytes, suppress adipocyte differentiation and triglyceride accumulation, stimulate lipolysis and fatty acid β-oxidation, and reduce inflammation. Concomitantly, the polyphenols modulate signaling pathways including the AMP-activated protein kinase, peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, PPAR gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor kappa B that regulate adipogenesis, antioxidant and anti-inflammatory responses. Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass, and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis. Limited human studies have been conducted in this area, and are inconsistent about the anti-obesity impact of dietary polyphenols, probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), chemical forms of the dietary polyphenols used and confounding factors such as other weight reducing agents. Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols.
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Cites
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“After eating polyphenol-rich foods or taking dietary supplement, humans achieve peak plasma polyphenol concentrations at less than 10 μM [172,174–177].”
BackgroundResveratrol improves health and survival of mice on a high-calorie diet
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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
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Resveratrol is not a direct activator of SIRT1 enzyme activity
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Cited by
The Role of Polyphenols in Human Health and Food Systems: A Mini-Review
Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00087 · Cited by 1,297
Mechanisms of body weight reduction and metabolic syndrome alleviation by tea
Yang, C. S., Zhang, J., Zhang, L., Huang, J., & Wang, Y. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500428 · Cited by 384
Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms
Lephart, E. D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.001 · Cited by 325
Nani, A., Murtaza, B., Sayed Khan, A., Khan, N. A., & Hichami, A. (2021) · Molecules · doi:10.3390/molecules26040985 · Cited by 321
Jiao, X., Wang, Y., Lin, Y., Lang, Y., Li, E., Zhang, X., Zhang, Q., Feng, Y., Meng, X., & Li, B. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.008 · Cited by 312
Metadata
- Authors
- Wang, S., Moustaid-Moussa, N., Chen, L., Mo, H., Shastri, A., Su, R., Bapat, P., Kwun, I., & Shen, C.-L.
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 25
- Issue
- 1
- Pages
- 1-18
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2064207652
- Cited by
- 896
- References
- 14
- FWCI
- 38.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, S., Moustaid-Moussa, N., Chen, L., Mo, H., Shastri, A., Su, R., Bapat, P., Kwun, I., & Shen, C.-L. (2014). Novel insights of dietary polyphenols and obesity. The Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2013.09.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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