CoChat
Sign Up
Cited by 45Ovarian function and disordersAntioxidant Activity and Oxidative StressReproductive Biology and Fertility

A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS)

Open access
Szczuko, Małgorzata, Zapalowska-Chwyć, Marta, Drozd, Radosław·2019·Molecules
DOI 10.3390/molecules24081508PMC PMC6514917
Open this paper in CoChat — free accountOpen PDF

Abstract

Introduction: According to a review of the literature, there is a lack of data on the mechanisms that participate in the suppression of inflammation that accompanies polycystic ovary syndrome (PCOS). Additionally, the changes in oxidative status resulting from a low-calorie diet have not been studied in a group of women with PCOS, and the oxidation and reduction processes associated with PCOS have not been explained. Material and methods: The study involved 49 women who were diagnosed with PCOS according to Rotterdam’s criteria, and 24 women voluntarily agreed to a three-month dietary intervention. The dietary intervention was carried out for 3 months. Glutathione peroxidase (GPx3) activity, the Ferric reducing ability of plasma, and uric acid concentration were measured spectrophotometrically both before and after the intervention. Statistical analysis was performed with the Statistica 10.0 software package, and a Pearson’s correlation matrix was generated. Results: A lower concentration of GPx3 was observed in women with PCOS (before the dietetic intervention began) compared with the GPx3 levels in healthy women. A relationship was shown between GPx3 levels and the concentration of prolactin, insulin on fasting, and triglycerides. After the dietary intervention, increases in uric acid and GPx3 activity were noted, as well as numerous relationships between anthropometric and biochemical parameters. The ferric reducing/antioxidant power did not change significantly. Conclusions: Inhibiting the effect of prolactin (by the level of reactive oxygen species) on the activity of GPx3 could be a starting point for the increase in antioxidative stress and the development of the inflammatory state associated with PCOS pathophysiology. Following a low-calorie diet with a lower glycemic index is proposed to silence inflammation by increasing the concentration of uric acid. During GPx3 mobilization, women with PCOS have a higher demand for selenium, and its deficiencies may contribute to disordered thyroid hormone synthesis. The three-month dietary intervention did not silence redox processes in the examined group of women.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/molecules24081508

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Low-GI diets are more successful at reducing inflammation and increasing insulin sensitivity in women with PCOS compared to conventional diets.

    “Research indicates that compared to conventional diets, low-GI diets are more successful at reducing inflammation [50] and increasing insulin sensitivity [51] in women with PCOS.”

    From Role of Omega-3 Fatty Acids in Improving Metabolic Dysfunctions in Polycystic Ovary Syndrome (2024) · cites this paper as [50]

    The Abstract proposes that a lower-GI, low-calorie diet may suppress inflammation in women with PCOS, and the Discussion reports increases in antioxidant measures after the intervention. But Methods §4.1 describes no conventional-diet comparison, so the paper does not establish that a low-GI diet is more successful. The insulin-sensitivity claim is attached to a different citation [51] and is not assessed here. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 46 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. [45]Tietz N.W. Text Book of Clinical Chemistry 3rd ed. W.B. Saunders Philadelphia, PA, USA 1999 809 861
  2. [46]Flohé L. Gunzler W.A. Assay of glutathione peroxidase Methods Enzymol. 1984 105 114 121 6727659

Cited by

Sorted by citations

Related

Authors
Szczuko, M., Zapalowska-Chwyć, M., & Drozd, R.
Affiliations
  • Pomeranian Medical University (PL)
  • Clinic of Gynecology and Urogynecology, Pomeranian Medical University, 70-204 Szczecin, Poland
  • West Pomeranian University of Technology in Szczecin (PL)
Corresponding author
Szczuko, Małgorzata
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2019-04-17
Volume
24
Issue
8
Pages
1508
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules24081508
PMC
PMC6514917
OpenAlex
W2939691564
Cited by
45
References
46
Citations by year
2026: 5 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 4 · 2021: 12 · 2020: 2 · 2019: 2
FWCI
4.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Pomorski Uniwersytet Medyczny W Szczecinie
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
polycystic ovary syndrome, low glycemic index diet, hypocaloric diet, uric acid, glutathione peroxidase 3, oxidative stress, inflammation, ferric reducing antioxidant power, prolactin, insulin, triglycerides, selenium deficiency, thyroid hormone synthesis
MeSH terms
Adult, Female, Glutathione Peroxidase, Humans, Inflammation, Polycystic Ovary Syndrome, Uric Acid, Glycemic Index

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review