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Uvaol Improves the Functioning of Fibroblasts and Endothelial Cells and Accelerates the Healing of Cutaneous Wounds in Mice
Open accessAbstract
Uvaol is a natural pentacyclic triterpene that is widely found in olives and virgin olive oil, exerting various pharmacological properties. However, information remains limited about how it affects fibroblasts and endothelial cells in events associated with wound healing. Here, we report the effect of uvaol in the in vitro and in vivo healing process. We show the positive effects of uvaol on migration of fibroblasts and endothelial cells in the scratch assay. Protein synthesis of fibronectin and laminin (but not collagen type I) was improved in uvaol-treated fibroblasts. In comparison, tube formation by endothelial cells was enhanced after uvaol treatment. Mechanistically, the effects of uvaol on cell migration involved the PKA and p38-MAPK signaling pathway in endothelial cells but not in fibroblasts. Thus, the uvaol-induced migratory response was dependent on the PKA pathway. Finally, topical treatment with uvaol caused wounds to close faster than in the control treatment using experimental cutaneous wounds model in mice. In conclusion, uvaol positively affects the behavior of fibroblasts and endothelial cells, potentially promoting cutaneous healing.
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Numerous in vitro and preclinical studies with minor components of OPO have shown promising results on different cardiometabolic traits.
“Numerous in vitro and preclinical studies have been conducted with one or more of these so-called minor components of OPO, offering promising results on different cardiometabolic traits [7–9].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [9]
The Introduction identifies uvaol as a triterpene found in olives, and the Discussion reports its beneficial effects in cell experiments and a mouse wound-healing model (no page numbers provided). This supports the cited paper as an example of in vitro and preclinical work on an olive component, but its reported outcomes concern cutaneous healing, not cardiometabolic traits. (LLM, conf=0.84)
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Metadata
- Authors
- Carmo, J., Cavalcante-Araújo, P., Silva, J., Ferro, J., Correia, A. C., Lagente, V., & Barreto, E.
- Affiliations
- Universidade Federal de Alagoas (BR)
- Laboratory of Cell Biology, Federal University of Alagoas, 57072-900 Maceió, Brazil
- Universidade de Pernambuco (BR)
- Inserm (FR)
- Corresponding author
- Barreto, Emiliano
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2020-10-28
- Volume
- 25
- Issue
- 21
- Pages
- 4982
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC7662923
- OpenAlex
- W3097276612
- Cited by
- 18
- References
- 54
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 6
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (308898/2018-4)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Keywords
- uvaol, pentacyclic triterpenes, virgin olive oil, skin wound healing, fibroblast migration, endothelial cell migration, endothelial tube formation, fibronectin, laminin, PKA signaling, p38 MAPK signaling, topical treatment
- MeSH terms
- Animals, Cell Movement, Cell Survival, Extracellular Matrix, Fibroblasts, Kinetics, Skin, Triterpenes, Wound Healing, MAP Kinase Signaling System, Endothelial Cells, p38 Mitogen-Activated Protein Kinases, Mice
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