The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions
Open accessAbstract
Astaxanthin is a natural lipid-soluble and red-orange carotenoid. Due to its strong antioxidant property, anti-inflammatory, anti-apoptotic, and immune modulation, astaxanthin has gained growing interest as a multi-target pharmacological agent against various diseases. In the current review, the anti-inflammation mechanisms of astaxanthin involved in targeting for inflammatory biomarkers and multiple signaling pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3, have been described. Furthermore, the applications of anti-inflammatory effects of astaxanthin in neurological diseases, diabetes, gastrointestinal diseases, hepatic and renal diseases, eye and skin disorders, are highlighted. In addition to the protective effects of astaxanthin in various chronic and acute diseases, we also summarize recent advances for the inconsistent roles of astaxanthin in infectious diseases, and give our view that the exact function of astaxanthin in response to different pathogen infection and the potential protective effects of astaxanthin in viral infectious diseases should be important research directions in the future.
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Cites
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Oxidative Stress Causes Muscle Structural Alterations via P38 MAPK Signaling in COPD Mouse Model
Mano, Y., Tsukamoto, M., Wang, K.-Y., Nabeshima, T., Kosugi, K., Tajima, T., Yamanaka, Y., Suzuki, H., Kawasaki, M., Nakamura, E., et al. (2022) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-022-01371-1 · Cited by 29
Zhang, H., Wang, M., Zhou, Y., Bao, S., Wang, F., & Li, C. (2024) · Marine Drugs · doi:10.3390/md22100469 · Cited by 16
Metadata
- Authors
- Chang, M. X., & Xiong, F.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2020-11-16
- Volume
- 25
- Issue
- 22
- Pages
- 5342
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W3100448104
- Cited by
- 268
- References
- 88
- FWCI
- 10.99
- Type
- journal article
- Language
- en
- Open access
- gold
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