Epilobium angustifolium L. as a Potential Herbal Component of Topical Products for Skin Care and Treatment—A Review
Open accessAbstract
Epilobium angustifolium L. (EA) has been used as a topical agent since ancient times. There has been an increasing interest in applying EA as a raw material used topically in recent years. However, in the literature, there are not many reports on the comprehensive application of this plant to skin care and treatment. EA contains many valuable secondary metabolites, which determine antioxidant, anti-inflammatory, anti-aging, and antiproliferative activity effects. One of the most important active compounds found in EA is oenothein B (OeB), which increases the level of ROS and protects cells from oxidative damage. OeB also influences wound healing and reduces inflammation by strongly inhibiting hyaluronidase enzymes and inhibiting COX-1 and COX-2 cyclooxygenases. Other compounds that play a key role in the context of application to the skin are flavonoids, which inhibit collagenase and hyaluronidase enzymes, showing anti-aging and anti-inflammatory properties. While terpenes in EA play an important role in fighting bacterial skin infections, causing, among other things cell membrane, permeability increase as well as the modification of the lipid profiles and the alteration of the adhesion of the pathogen to the animal cells. The available scientific information on the biological potential of natural compounds can be the basis for the wider use of EA in skin care and treatment. The aim of the article is to review the existing literature on the dermocosmetic use of E. angustifolium.
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Fireweed (Epilobium angustifolium) and sea fennel (Crithmum Maritimum) extracts display anti-inflammatory effects and can protect from UV-induced oxidative damage.
“Fireweed (Epilobium angustifolium) and sea fennel (Crithmum Maritimum) extracts also display anti-inflammatory effects and can protect from UV-induced oxidative damage [30,31].”
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Flagged first, then by citations
Cited by
Sorted by citations
Chang, T.-M., Wu, C.-C., Huang, H.-C., Lu, J.-Y., Chuang, C.-H., Kao, P.-L., Tang, W.-H., Liu, L. T.-C., Qiu, W.-Y., Percec, I., et al. (2025) · Cosmetics · doi:10.3390/cosmetics12050186 · Cited by 7 · see citing works
- Authors
- Nowak, A., Zielonka-Brzezicka, J., Perużyńska, M., & Klimowicz, A.
- Affiliations
- Pomeranian Medical University (PL)
- Corresponding author
- Nowak, Anna
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2022-05-31
- Volume
- 27
- Issue
- 11
- Pages
- 3536
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC9182203
- OpenAlex
- W4281630311
- Cited by
- 17
- References
- 103
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 2
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Chamaenerion angustifolium, willowherb, cosmeceuticals, skin care, oenothein B, flavonoids, terpenes, hyaluronidase inhibition, collagenase inhibition, anti-aging, anti-inflammatory activity, antioxidant activity, wound healing, bacterial skin infections, secondary metabolites
- MeSH terms
- Animals, Anti-Inflammatory Agents, Hyaluronoglucosaminidase, Plant Extracts, Skin Care, Onagraceae, Epilobium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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