The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels
Open accessAbstract
To create functional tissue engineering scaffolds, biomaterials should mimic the native extracellular matrix of the tissue to be regenerated. Simultaneously, the survival and functionality of stem cells should also be enhanced to promote tissue organisation and repair. Hydrogels, but in particular, peptide hydrogels, are an emerging class of biocompatible scaffolds which act as promising self-assembling biomaterials for tissue engineering and regenerative therapies, ranging from articular cartilage regeneration at joint defects, to regenerative spinal cord injury following trauma. To enhance hydrogel biocompatibility, it has become imperative to consider the native microenvironment of the site for regeneration, where the use of functionalised hydrogels with extracellular matrix adhesion motifs has become a novel, emerging theme. In this review, we will introduce hydrogels in the context of tissue engineering, provide insight into the complexity of the extracellular matrix, investigate specific adhesion motifs that have been used to generate functionalised hydrogels and outline their potential applications in a regenerative medicine setting. It is anticipated that by conducting this review, we will provide greater insight into functionalised hydrogels, which may help translate their use towards therapeutic roles.
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3D-printed bioengineered scaffolds are designed to mimic native bone and cartilage structure, supporting cell adhesion, migration, and differentiation for improved regenerative outcomes.
“One emerging area of biomimetic research involves 3D-printed bioengineered scaffolds. These personalized scaffolds are designed to mimic native bone and cartilage structure, supporting cell adhesion, migration, and differentiation for improved regenerative outcomes [121].”
From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [121]
Section 1.3 describes scaffolds modified to mimic features of native extracellular matrix and promote cell adhesion; section 5.1 reports that functionalised hydrogels can support chondrogenic differentiation and replicate characteristics of cartilage ECM. The copy does not establish that these scaffolds are personalized or 3D-printed, mimic native bone and cartilage structure, or support cell migration. (LLM, conf=0.86)
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Halim, M. S. A., Nadernezhad, A., Kopecky, C., Hauser, S., Kilian, K. A., & Loessner, D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30151-3.00005-x
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Hydrogel: synthesis, physicochemical properties, and medical uses
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- Authors
- Morwood, A. J., El-Karim, I. A., Clarke, S. A., & Lundy, F. T.
- Affiliations
- Queen's University Belfast (GB)
- Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
- Corresponding author
- Lundy, Fionnuala T.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2023-06-07
- Volume
- 28
- Issue
- 12
- Pages
- 4616
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC10302969
- OpenAlex
- W4380050563
- Cited by
- 85
- References
- 129
- Citations by year
- 2026: 30 · 2025: 36 · 2024: 18 · 2023: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (acceptedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Department for the Economy (Northern Ireland)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- extracellular matrix, peptide hydrogels, tissue engineering scaffolds, stem cell survival, cartilage regeneration, spinal cord injury, regenerative medicine, hydrogel biocompatibility
- MeSH terms
- Tissue Adhesions, Biocompatible Materials, Extracellular Matrix, Humans, Hydrogels, Tissue Engineering, Tissue Scaffolds
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