The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing
Open accessAbstract
Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead to diabetic foot ulcer (DFU). DFU is associated with impaired wound healing, due to inappropriate cellular and cytokines response, infection, poor vascularization, and neuropathy. Effective therapeutic strategies for the management of impaired wound could be attained through a better insight of molecular mechanism and pathophysiology of diabetic wound healing. Nanotherapeutics-based agents engineered within 1–100 nm levels, which include nanoparticles and nanoscaffolds, are recent promising treatment strategies for accelerating diabetic wound healing. Nanoparticles are smaller in size and have high surface area to volume ratio that increases the likelihood of biological interaction and penetration at wound site. They are ideal for topical delivery of drugs in a sustained manner, eliciting cell-to-cell interactions, cell proliferation, vascularization, cell signaling, and elaboration of biomolecules necessary for effective wound healing. Furthermore, nanoparticles have the ability to deliver one or more therapeutic drug molecules, such as growth factors, nucleic acids, antibiotics, and antioxidants, which can be released in a sustained manner within the target tissue. This review focuses on recent approaches in the development of nanoparticle-based therapeutics for enhancing diabetic wound healing.
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Cited by
Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine
Huang, F., Lu, X., Yang, Y., Yang, Y., Li, Y., Kuai, L., Li, B., Dong, H., & Shi, J. (2023) · Advanced Science · doi:10.1002/advs.202203308 · Cited by 365
Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes
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Functional molecule-mediated assembled copper nanozymes for diabetic wound healing
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Dai, S., Jiang, L., Liu, L., Su, Z., Yao, L., Yang, P., & Huang, N. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae119 · Cited by 43
Metadata
- Authors
- Ezhilarasu, H., Vishalli, D., Dheen, S. T., Bay, B.-H., & Srinivasan, D. K.
- Venue
- Nanomaterials
- Publisher
- MDPI AG
- Published
- 2020-06-25
- Volume
- 10
- Issue
- 6
- Pages
- 1234
- ISSN
- 2079-4991 (ISSN-L)
- OpenAlex
- W3037395110
- Cited by
- 210
- References
- 12
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- gold
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