The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death
Open accessAbstract
Nanoparticles are emerging as a useful tool for a wide variety of biomedical, consumer and instrumental applications that include drug delivery systems, biosensors and environmental sensors. In particular, nanoparticles have been shown to offer greater specificity with enhanced bioavailability and less detrimental side effects as compared to the existing conventional therapies in nanomedicine. Hence, bionanotechnology has been receiving immense attention in recent years. However, despite the extensive use of nanoparticles today, there is still a limited understanding of nanoparticle-mediated toxicity. Both in vivo and in vitro studies have shown that nanoparticles are closely associated with toxicity by increasing intracellular reactive oxygen species (ROS) levels and/or the levels of pro-inflammatory mediators. The homeostatic redox state of the host becomes disrupted upon ROS induction by nanoparticles. Nanoparticles are also known to up-regulate the transcription of various pro-inflammatory genes, including tumor necrosis factor-α and IL (interleukins)-1, IL-6 and IL-8, by activating nuclear factor-kappa B (NF-κB) signaling. These sequential molecular and cellular events are known to cause oxidative stress, followed by severe cellular genotoxicity and then programmed cell death. However, the exact molecular mechanisms underlying nanotoxicity are not fully understood. This lack of knowledge is a significant impediment in the use of nanoparticles in vivo. In this review, we will provide an assessment of signaling pathways that are involved in the nanoparticle- induced oxidative stress and propose possible strategies to circumvent nanotoxicity.
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Cites
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Cited by
Schirinzi, G. F., Pérez-Pomeda, I., Sanchís, J., Rossini, C., Farré, M., & Barceló, D. (2017) · Environmental Research · doi:10.1016/j.envres.2017.08.043 · Cited by 902
Environmental factors in epithelial barrier dysfunction
Celebi Sözener, Z., Cevhertas, L., Nadeau, K., Akdis, M., & Akdis, C. A. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.04.024 · Cited by 384
Nanomaterials in food and agriculture: An overview on their safety concerns and regulatory issues
Jain, A., Ranjan, S., Dasgupta, N., & Ramalingam, C. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1160363 · Cited by 367
Chawla, R., Sivakumar, S., & Kaur, H. (2021) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2020.100024 · Cited by 348
Recent progress of magnetic nanoparticles in biomedical applications: A review
Anik, M. I., Hossain, M. K., Hossain, I., Mahfuz, A. M. U. B., Rahman, M. T., & Ahmed, I. (2021) · Nano Select · doi:10.1002/nano.202000162 · Cited by 300
Metadata
- Authors
- Khanna, P., Ong, C., Bay, B., & Baeg, G.
- Venue
- Nanomaterials
- Publisher
- MDPI AG
- Published
- 2015-06-30
- Volume
- 5
- Issue
- 3
- Pages
- 1163-1180
- ISSN
- 2079-4991 (ISSN-L)
- OpenAlex
- W1579782115
- Cited by
- 580
- References
- 8
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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