Targeting Multiple Signaling Pathways by Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate
Open accessAbstract
Cell signaling pathways, responsible for maintaining a balance between cell proliferation and death, have emerged as rational targets for the management of cancer. Emerging data amassed from various laboratories around the world suggests that green tea, particularly its major polyphenolic constituent (−)-epigallocatechin-3-gallate (EGCG), possesses remarkable cancer chemopreventive and therapeutic potential against various cancer sites in animal tumor bioassay systems and in some human epidemiologic studies. EGCG has been shown to modulate multiple signal transduction pathways in a fashion that controls the unwanted proliferation of cells, thereby imparting strong cancer chemopreventive as well as therapeutic effects. This review discusses the modulations of important signaling events by EGCG and their implications in cancer management.(Cancer Res 2006;66(5):2500–5)
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Adipose tissue may be a major source of pro-inflammatory mediators that initiate chronic inflammation, insulin resistance and atherosclerosis in obesity.
“Based on these data, it was suggested that adipose tissue plays an important immune role and may be a major source of pro-inflammatory mediators which initiate the development of chronic inflammation, insulin resistance and atherosclerosis, all of which are characteristics of the metabolic dysregulation associated with obesity.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [8]
White adipose tissue synthesises and releases the pro-inflammatory cytokine TNF-a.
“who showed that white adipose tissue synthesises and releases the pro-inflammatory cytokine TNF-a.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [8]
In animal models of insulin resistance, TNF-a antibody infusion ameliorates insulin signalling.
“In animal models of insulin resistance, infusion of TNF-a antibodies has been reported to ameliorate insulin signalling (8,149) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [8]
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- Authors
- Khan, N., Afaq, F., Saleem, M., Ahmad, N., & Mukhtar, H.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Cancer Research
- Published
- 2006-03-01
- Volume
- 66
- Issue
- 5
- Pages
- 2500-2505
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2135642745
- Cited by
- 820
- References
- 24
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 27 · 2023: 33 · 2022: 38 · 2021: 43 · 2020: 33 · 2019: 29 · 2018: 47 · 2017: 45 · 2016: 47 · 2015: 42 · 2014: 35 · 2013: 48 · 2012: 61
- FWCI
- 37.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (RO1 CA 78809)
- National Cancer Institute (R01CA101039, R01CA 78809, R01CA078809)
- National Institute of Diabetes and Digestive and Kidney Diseases (P50DK065303)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Keywords
- epigallocatechin gallate, green tea polyphenols, chemoprevention, cancer therapy, signaling pathways, signal transduction, cell proliferation, apoptosis, green tea
- MeSH terms
- Animals, Catechin, Cell Cycle, Clinical Trials as Topic, Humans, Neovascularization, Pathologic, Protease Inhibitors, Tea, Signal Transduction, NF-kappa B, Anticarcinogenic Agents, Apoptosis, Receptor, IGF Type 1, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Vascular Endothelial Growth Factor A, ErbB Receptors
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