Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial
Open accessAbstract
Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63–0.94), 0.71 (0.58–0.87), and 0.78 (0.64–0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5–1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
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According to epidemiological and clinical studies, reduced dietary intake of fatty acids, especially ω3, is associated with mood disorders and depression.
“According to both epidemiological and clinical studies, a reduced dietary intake of fatty acids, especially ω3, is associated with mood disorders and depression [446,447,448,449].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [449]
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- Authors
- Sánchez-Villegas, A., Álvarez-Pérez, J., Toledo, E., Salas-Salvadó, J., Ortega-Azorín, C., Zomeño, M. D., Vioque, J., Martínez, J. A., Romaguera, D., Pérez-López, J., López-Miranda, J., Estruch, R., Bueno-Cavanillas, A., Arós, F., Tur, J. A., Tinahones, F. J., Lecea, O., Martín, V., Ortega-Calvo, M., Vázquez, C., Pintó, X., Vidal, J., Daimiel, L., Delgado-Rodríguez, M., Matía, P., Corella, D., Díaz-López, A., Babio, N., Muñoz, M. Á., Fitó, M., García de la Hera, M., Abete, I., García-Rios, A., Ros, E., Ruíz-Canela, M., Martínez-González, M. Á., Izquierdo, M., & Serra-Majem, L.
- Affiliations
- Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain
- Universidad de Las Palmas de Gran Canaria (ES)
- Instituto de Salud Carlos III (ES)
- Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
- Cardiovascular Risk and Nutrition, IMIM-Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain
- Consorcio CIBER, M.P. Epidemiología y Salud Pública (CIBEREsp), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
- School of Health Sciences. University of Málaga-IBIMA, 29010 Malaga, Spain
- University of the Basque Country (ES)
- Consorcio CIBER, M.P. Diabetes y enfermedades metabólicas (CIBERDem), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
- Madrid Institute for Advanced Studies (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040 Madrid, Spain
- Universitat de València (ES)
- Institut Català de la Salut (ES)
- Universidad de Navarra (ES)
- ORCID
- Álvarez-Pérez, Jacqueline
- Toledo, Estefanía
- Salas-Salvadó, Jordi
- Vioque, Jesús
- Martínez, Jose Alfredo
- Romaguera, Dora
- Pérez-López, Jessica
- Estruch, Ramón
- Bueno-Cavanillas, Aurora
- Arós, Fernando
- Tur, Josep A.
- Tinahones, Francisco J.
- Martín, Vicente
- Ortega-Calvo, M.
- Vázquez, Clotilde
- Pintó, Xavier
- Daimiel, Lidia
- Matía, Pilar
- Corella, Dolores
- Babio, Nancy
- Muñoz, Miguel Ángel
- Fitó, Montserrat
- Abete, Itziar
- Ros, Emilio
- Ruíz-Canela, Miguel
- Izquierdo, Marisol
- Serra-Majem, Lluis
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-12-18
- Volume
- 10
- Issue
- 12
- Pages
- 2000
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6315981
- OpenAlex
- W2905029176
- Cited by
- 72
- References
- 36
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 12 · 2020: 7 · 2019: 7 · 2018: 1 · 2016: 1
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
- Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
- Communities in ADDI (University of the Basque Country) (submittedVersion, other-oa)
- Communities in ADDI (Universidad del Pais Vasco) (submittedVersion, other-oa)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, cc-by)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
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- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion, cc-by)
- Hispana (submittedVersion, cc-by)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
- Funders
- Spanish Ministry of Health-Fondo de Investigación Sanitaria (PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14-00696, PI14/01206, PI14/01919, PI14/00853)
- European Research Council (Advanced Research Grant 2013–2018; 340918)
- Recercaixa grant (2013ACUP00194)
- Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016)
- FEDER funds (CB06/03)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- seafood consumption, fish consumption, omega-3 fatty acids, depression, depressive symptoms, U-shaped relationship, PREDIMED-Plus trial, Mediterranean diet
- MeSH terms
- Aged, Animals, Energy Intake, Cross-Sectional Studies, Depression, Depressive Disorder, Diet, Diet Surveys, Feeding Behavior, Female, Fishes, Humans, Male, Middle Aged, Surveys and Questionnaires, Fatty Acids, Omega-3, Prevalence, Logistic Models, Odds Ratio, Seafood
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