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Cited by 511

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function

Open access
Tan, Bee Ling, Norhaizan, Mohd Esa·2019·Nutrients

Abstract

Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to cell-mediated immunity in creating an oxidative environment. Food is a vitally important energy source; it affects brain function and provides direct energy. Several studies have indicated that high-fat consumption causes overproduction of circulating free fatty acids and systemic inflammation. Immune cells, free fatty acids, and circulating cytokines reach the hypothalamus and initiate local inflammation through processes such as microglial proliferation. Therefore, the role of high-fat diet (HFD) in promoting oxidative stress and neurodegeneration is worthy of further discussion. Of particular interest in this article, we highlight the associations and molecular mechanisms of HFD in the modulation of inflammation and cognitive deficits. Taken together, a better understanding of the role of oxidative stress in cognitive impairment following HFD consumption would provide a useful approach for the prevention of cognitive dysfunction.

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Metadata

Authors
Tan, B. L., & Norhaizan, M. E.
Venue
Nutrients
Publisher
MDPI AG
Published
2019-10-25
Volume
11
Issue
11
Pages
2579
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2981451354
Cited by
511
References
29
FWCI
20.80
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function. https://app.cochat.ai/papers/10.3390/nu11112579
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Tan, B. L., & Norhaizan, M. E. (2019). Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function. Nutrients. https://doi.org/10.3390/nu11112579

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