Dietary Suberic Acid Protects Against UVB-Induced Skin Photoaging in Hairless Mice
Open accessAbstract
Ultraviolet (UV) radiation is a major cause of skin photoaging, which is mainly characterized by dryness and wrinkle formation. In the current study, we investigated the anti-photoaging effects of dietary suberic acid, a naturally occurring photochemical, using UVB-irradiated hairless mice. Mice were exposed to UVB three times weekly and fed diets containing three different suberic acid concentrations (0.05%, 0.1% and 0.2%) for 10 weeks. It was found that suberic acid inhibited UVB-induced skin dryness, wrinkle formation, and epidermal thickness in hairless mice. In parallel with phenotypic changes, suberic acid attenuated UVB-induced matrix metalloproteinase (MMP) genes (MMP1a, MMP1b, MMP3, and MMP9), while accelerating collagen genes including collagen type I alpha 1 chain (COL1A1), COL1A2, and COL3A1 and hyaluronic acid synthases genes (HAS1, HAS2 and HAS3). We further demonstrated that suberic acid upregulated the molecules involved in the transforming growth factor–β (TGF-β)/SMAD pathway, but downregulated the molecules participating in the mitogen-activated protein kinase (MAPK)/activator protein 1 (AP-1) signaling in UVB-irritated hairless mice. Collectively, we propose that suberic acid may be a promising agent for treating skin photoaging.
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Suberic acid upregulates expression of molecules in the TGF-beta/Smad pathway and inactivates the MAPK/AP-1 pathway.
“Mechanistically, suberic acid upregulates the expression of molecules in the TGF-β/Smad pathway and inactivates the MAPK/AP-1 pathway.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [129]
Supplementation with dietary suberic acid protected against UVB-induced skin photoaging in hairless mice.
“Supplementation with dietary suberic acid, a dibasic fatty acid, protected against UVB-induced skin photoaging in hairless mice.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [129]
Oral administration of suberic acid restrained UVB-induced skin dryness, wrinkle formation, and epidermal thickness.
“Oral administration of suberic acid restrained UVB-induced skin dryness, wrinkle formation, and epidermal thickness.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [129]
Oral suberic acid downregulated expression of MMP-1, MMP-3, and MMP-9 and enhanced expression of collagen and HA in back skin of mice.
“Oral suberic acid downregulated the expression of MMP-1, MMP-3, and MMP-9 and enhanced the expression of collagen and HA in the back skin of mice [129].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [129]
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- Authors
- Kang, W., Choi, D., & Park, T.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Park, Taesun
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-12-04
- Volume
- 11
- Issue
- 12
- Pages
- 2948
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6950119
- OpenAlex
- W2994213268
- Cited by
- 49
- References
- 38
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 9 · 2023: 4 · 2022: 12 · 2021: 7 · 2020: 2
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2019R1A2C2003340)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- suberic acid, photoaging, UVB irradiation, dietary supplementation, dry skin, wrinkle formation, epidermal thickness, matrix metalloproteinases, collagen synthesis, hyaluronan synthase, TGF-β/Smad signaling, MAPK/AP-1 signaling, hairless mice
- MeSH terms
- Collagen Type I, alpha 1 Chain, Administration, Oral, Animals, Caprylates, Cell Line, Collagen, Dicarboxylic Acids, Diet, Female, Humans, Mice, Hairless, Skin, Ultraviolet Rays, Skin Aging, Protective Agents, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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