Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

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Alzheimer's Disease Is a Synaptic Failure

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

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Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

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Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

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Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

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Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of alzheimer’s disease.

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Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

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Regulation of NMDA receptor trafficking by amyloid-β

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

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PSD-95 Involvement in Maturation of Excitatory Synapses

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Mechanisms of CaMKII action in long-term potentiation

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Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

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Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

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Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting

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Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

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AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

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Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.

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Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

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Synaptic AMPA receptor plasticity and behavior

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Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

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Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

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Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

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Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

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Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking

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Ras and Rap control AMPA receptor trafficking during synaptic plasticity

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Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD

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An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression

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Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

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LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β

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Aβ Oligomers Cause Localized Ca ²⁺ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

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Soluble Aβ Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

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Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

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Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

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Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

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DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

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Regulation of AMPA receptor trafficking and synaptic plasticity

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Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

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Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins

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Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

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Internalization of ionotropic glutamate receptors in response to mGluR activation

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Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

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Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

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Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

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Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis

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Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

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PSD-95 is required for activity-driven synapse stabilization.

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Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

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Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

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Extrasynaptic Membrane Trafficking Regulated by GluR1 Serine 845 Phosphorylation Primes AMPA Receptors for Long-term Potentiation

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The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

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Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

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Synapses and Alzheimer's Disease

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Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

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Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.

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Synapse-specific regulation of AMPA receptor function by PSD-95.

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Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

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Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins

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Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression

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Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices

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Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs

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Requirement of AMPA Receptor GluR2 Phosphorylation for Cerebellar Long-Term Depression

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Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease

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Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit

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Microtubule-associated protein tau is essential for long-term depression in the hippocampus

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Aβ1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

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Cyclin-Dependent Kinases in Brain Development and Disease

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Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD

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Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

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Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers

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Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression

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Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β peptide (25–35) enhances phosphorylation of tau in hippocampal neurons

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Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating

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