The Preventive Effect of β-Carotene on Denervation-Induced Soleus Muscle Atrophy in Mice
Open accessAbstract
Muscle atrophy increases the production of reactive oxygen species and the expression of atrophy-related genes, which are involved in the ubiquitin-proteasome system. In the present study, we investigated the effects of β-carotene on oxidative stress (100 μM-H2O2)-induced muscle atrophy in murine C2C12 myotubes. β-Carotene (10 μM) restored the H2O2-induced decreased levels of myosin heavy chain and tropomyosin (P< 0·05, n 3) and decreased the H2O2-induced increased levels of ubiquitin conjugates. β-Carotene reduced the H2O2-induced increased expression levels of E3 ubiquitin ligases (Atrogin-1 and MuRF1) and deubiquitinating enzymes (USP14 and USP19) (P< 0·05, n 3) and attenuated the H2O2-induced nuclear localisation of FOXO3a. Furthermore, we determined the effects of β-carotene on denervation-induced muscle atrophy. Male ddY mice (8 weeks old, n 30) were divided into two groups and orally pre-administered micelle with or without β-carotene (0·5 mg once daily) for 2 weeks, followed by denervation in the right hindlimb. β-Carotene was further administered once daily until the end of the experiment. At day 3 after denervation, the ratio of soleus muscle mass in the denervated leg to that in the sham leg was significantly higher in β-carotene-administered mice than in control vehicle-administered ones (P< 0·05, n 5). In the denervated soleus muscle, β-carotene administration significantly decreased the expression levels of Atrogin-1, MuRF1, USP14 and USP19 (P< 0·05, n 5) and the levels of ubiquitin conjugates. These results indicate that β-carotene attenuates soleus muscle loss, perhaps by repressing the expressions of Atrogin-1, MuRF1, USP14 and USP19, at the early stage of soleus muscle atrophy.
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β-Carotene attenuates muscle atrophy by repressing expressions of MAFbx, MuRF1, USP14, and USP19 in murine C2C12 myotube and mouse soleus muscle.
“It attenuated muscle atrophy by repressing the expressions of MAFbx, MuRF1, Ubiquitin-specific processing protease 14, and Ubiquitin-specific processing protease 19 in murine C2C12 myotube and mouse soleus muscle [65].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [65]
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Dutt, V., Kaur, N. J., Sharma, O., & Mittal, A. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297925603351 · Cited by 1 · see citing works
Yang, S., Yue, N., & Zeng, X. (2015) · International Journal of Morphology · doi:10.4067/s0717-95022015000300027 · Cited by 1 · see citing works
Nutrition, Functional Foods, and Exercise: A Review
Aoi, W., & Naito, Y. (2015) · CRC Press eBooks · doi:10.1201/b19308-51
Studies on Skeletal Muscle Health and Functional Food Components
Yamaji, R. (2024) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.77.397
Self-citationJang, E., Lee, T.-B., Choi, S., Tonini, L., Nam, D., Jung, J.-Y., Choi, H.-J., & Ahn, C. (2026) · Journal of Medicinal Food · doi:10.1177/1096620x261426879
The Roles of Vitamin A and Provitamin A in Skeletal Muscle Health
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Self-citationThe role of USP19 in human diseases: from molecular function to clinical relevance
Wang, Q., Cao, H., Wei, H., Wang, X., Luo, T., & Yin, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1877228
- Authors
- Ogawa, M., Kariya, Y., Kitakaze, T., Yamaji, R., Harada, N., Sakamoto, T., Hosotani, K., Nakano, Y., & Inui, H.
- Affiliations
- Osaka Prefecture University (JP)
- University of Fukuchiyama (JP)
- Osaka Women's Junior College (JP)
- Corresponding author
- Yamaji, Ryoichi
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-10-09
- Volume
- 109
- Issue
- 8
- Pages
- 1349-1358
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2109503539
- Cited by
- 58
- References
- 42
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 2 · 2013: 1
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23580182, 23617017)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- beta-carotene, muscle atrophy, denervation, soleus muscle, oxidative stress, hydrogen peroxide, ubiquitin-proteasome system, atrogin-1, MuRF1, USP14, USP19, E3 ubiquitin ligase, deubiquitinase, FOXO3, myotubes
- MeSH terms
- Forkhead Box Protein O3, Analysis of Variance, Animals, Cells, Cultured, Gene Expression Regulation, Hydrogen Peroxide, Male, Muscle Denervation, Muscle Proteins, Muscular Atrophy, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Muscle, Skeletal, Muscle Fibers, Skeletal, beta Carotene, Reverse Transcriptase Polymerase Chain Reaction, Myoblasts, Skeletal, Ubiquitin Thiolesterase, Ubiquitin-Protein Ligase Complexes, Mice, Forkhead Transcription Factors
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