The aging musculoskeletal system and obesity-related considerations with exercise
Open accessAbstract
Advancing age and adiposity contribute to musculoskeletal degenerative diseases and the development of sarcopenic obesity. The etiology of muscle loss is multifactorial, and includes inflammation, oxidative stress and hormonal changes, and is worsened by activity avoidance due to fear of pain. The risk for mobility disability and functional impairment rises with severity of obesity in the older adult. Performance measures of walking distance, walking speed, chair rise, stair climb, body transfers and ability to navigate obstacles on a course are adversely affected in this population, and this reflects decline in daily physical functioning. Exercise training is an ideal intervention to counteract the effects of aging and obesity. The 18 randomized controlled trials of exercise studies with or without diet components reviewed here indicate that 3-18 month programs that included aerobic and strengthening exercise (2-3 days per week) with caloric restriction (typically 750 kcal deficit/day), induced the greatest change in functional performance measures compared with exercise or diet alone. Importantly, resistance exercise attenuates muscle mass loss with the interventions. These interventions can also combat factors that invoke sarcopenia, including inflammation, oxidative stress and insulin resistance. Therefore, regular multimodal exercise coupled with diet appears to be very effective for counteracting sarocpenic obesity and improving mobility and function in the older, obese adult.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These guidelines do not differ for the more than one-third of older adults with obesity whose muscle function is compromised nor do they include a recommendation to reduce body weight and fat to enhance physical function or mobility in these patients.
“These guidelines do not differ for the more than one-third of older adults with obesity whose muscle function is compromised (8) nor do they include a recommendation to reduce body weight and fat to enhance physical function or mobility in these patients.”
From Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial (2015) · cites this paper as [8]
Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredThe majority of published RT studies in older adults (≥65 y of age) have been conducted in normal-weight or nonobese individuals.
“The majority of published RT studies in older adults ($65 y of age) have been conducted in normal-weight or nonobese individuals (8,24).”
From Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial (2015) · cites this paper as [8]
Section 9 says the review focuses on exercise trials involving obese older adults, and §9.1 describes several resistance-exercise trials in that population. Neither passage compares those trials with the full body of published RT studies in adults aged 65 or older. Searches for normal-weight or nonobese participants and for a majority of RT studies did not establish the claimed distribution. (LLM, conf=0.72)
Experimental — accuracy not yet measuredExercise interventions such as RET or MET have been used as an effective method for improving muscle function and increasing muscle mass by stimulating muscle protein synthesis in older adults.
“Exercise interventions, such as resistance exercise training (RET) that is employed alone or comprises multicomponent exercise training (MET)—including aerobics, balance, and function tasks—have been used as an effective method for improving muscle function and increasing muscle mass by stimulating muscle protein synthesis in older adults [10,11,12,13,14].”
From Effects of Protein Supplementation Combined with Exercise Intervention on Frailty Indices, Body Composition, and Physical Function in Frail Older Adults (2018) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907 · see citing works
Global burden of obesity in 2005 and projections to 2030
Kelly, T., Yang, W., Chen, C.-S., Reynolds, K., & He, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.102 · Cited by 3,319 · see citing works
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256 · cited 1× · see citing works
“A recent statement from the International Working Groups on Sarcopenia indicates that populations who are targets include those who have difficulty rising from a chair unassisted and have gait speeds 1.0 m/s (Fielding et al., 2011).”
BackgroundInfluentialVisser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403 · see citing works
Phenotype of frailty: characterization in the women's health and aging studies
Bandeen-Roche, K., Xue, Q.-L., Ferrucci, L., Walston, J., Guralnik, J. M., Chaves, P., Zeger, S. L., & Fried, L. P. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.3.262 · Cited by 1,215 · see citing works
Physical Activity and Health: A Report of the Surgeon General
Satcher, D. S., Marks, J. S., Bales, V. S., Daily, L. A., Speers, M. A., & Trowbridge, F. L. (1996) · PsycEXTRA Dataset · doi:10.1037/e305102003-001 · Cited by 1,104 · see citing works
Weight loss, exercise, or both and physical function in obese older adults
Villareal, D. T., Chode, S., Parimi, N., Sinacore, D. R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., & Shah, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008234 · Cited by 1,096 · see citing works
Sarcopenic obesity: definition, cause and consequences
Stenholm, S., Harris, T. B., Rantanen, T., Visser, M., Kritchevsky, S. B., & Ferrucci, L. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328312c37d · Cited by 1,070 · see citing works
Messier, S. P., Loeser, R. F., Miller, G. D., Morgan, T. M., Rejeski, W. J., Sevick, M. A., Ettinger, W. H., Pahor, M., & Williamson, J. D. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20256 · Cited by 1,065 · see citing works
Inflammatory markers and loss of muscle mass (sarcopenia) and strength
Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., & Visser, M. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.049 · Cited by 1,047 · see citing works
Appendicular skeletal muscle mass: effects of age, gender, and ethnicity
Gallagher, D., Visser, M., De Meersman, R. E., Sepúlveda, D., Baumgartner, R. N., Pierson, R. N., Harris, T., & Heymsfield, S. B. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.1.229 · Cited by 966 · see citing works
Sarcopenic obesity: A new category of obesity in the elderly
Zamboni, M., Mazzali, G., Fantin, F., Rossi, A., & Di Francesco, V. (2008) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.10.002 · Cited by 953 · see citing works
Sarcopenic Obesity Predicts Instrumental Activities of Daily Living Disability in the Elderly
Baumgartner, R. N., Wayne, S. J., Waters, D. L., Janssen, I., Gallagher, D., & Morley, J. E. (2004) · Obesity Research · doi:10.1038/oby.2004.250 · Cited by 937 · see citing works
Visser, M., Kritchevsky, S. B., Goodpaster, B. H., Newman, A. B., Nevitt, M., Stamm, E., & Harris, T. B. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50217.x · Cited by 845 · see citing works
Harvie, M. N., Pegington, M., Mattson, M. P., Frystyk, J., Dillon, B., Evans, G., Cuzick, J., Jebb, S. A., Martin, B., Cutler, R. G., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.171 · Cited by 804 · see citing works
Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans
Vincent, H. K., & Taylor, A. G. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803177 · Cited by 738 · see citing works
Self-citationFat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y
Schutz, Y., Kyle, U. G., & Pichard, C. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802037 · Cited by 668 · see citing works
Oxidative Stress, Molecular Inflammation and Sarcopenia
Meng, S.-J., & Yu, L.-J. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041509 · Cited by 637 · see citing works
Grotle, M., Hagen, K. B., Natvig, B., Dahl, F. A., & Kvien, T. K. (2008) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-9-132 · Cited by 613 · see citing works
Johnson, J. B., Summer, W., Cutler, R. G., Martin, B., Hyun, D.-H., Dixit, V. D., Pearson, M., Nassar, M., Tellejohan, R., Maudsley, S., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.005 · Cited by 604 · see citing works
Sarcopenic obesity and inflammation in the InCHIANTI study
Schrager, M. A., Metter, E. J., Simonsick, E., Ble, A., Bandinelli, S., Lauretani, F., & Ferrucci, L. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00627.2006 · Cited by 594 · see citing works
Adipose Tissue: The New Endocrine Organ? A Review Article
Wozniak, S. E., Gee, L. L., Wachtel, M. S., & Frezza, E. E. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0585-3 · Cited by 585 · see citing works
Villareal, D. T., Apovian, C. M., Kushner, R. F., & Klein, S. (2005) · Obesity Research · doi:10.1038/oby.2005.228 · Cited by 579 · see citing works
Review Article: Sarcopenia: Causes, Consequences, and Preventions
Marcell, T. J. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.10.m911 · Cited by 536 · cited 2× · see citing works
“Skeletal muscle protein synthesis decreases concurrent with muscle mitochondrial function (Marcell, 2003).”
BackgroundThomas, D. R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.03.008 · Cited by 521 · see citing works
Physical inactivity, sedentary lifestyle and obesity in the European Union
Martínez‐González, M. Á., Martínez, J. A., Hu, F. B., Gibney, M., & Kearney, J. M. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801049 · Cited by 472 · see citing works
Roelofs, J., Goubert, L., Peters, M. L., Vlaeyen, J. W. S., & Crombez, G. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2003.11.016 · Cited by 472 · cited 1× · see citing works
“A focus on the pain and negative aspects of pain likely contribute to hypervigilance to pain sensations and physical inactivity (Roelofs et al., 2004).”
BackgroundFrailty, Body Mass Index, and Abdominal Obesity in Older People
Hubbard, R. E., Lang, I., Llewellyn, D. J., & Rockwood, K. J. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp186 · Cited by 459 · see citing works
Sarcopenic Obesity: The Confluence of Two Epidemics
Roubenoff, R. (2004) · Obesity Research · doi:10.1038/oby.2004.107 · Cited by 453 · see citing works
Newman, A. B., Lee, J. S., Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Nevitt, M., & Harris, T. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.872 · Cited by 445 · see citing works
Davison, K. K., Ford, E. S., Cogswell, M. E., & Dietz, W. H. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50508.x · Cited by 435 · see citing works
Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity
Vincent, H. K., Innes, K. E., & Vincent, K. R. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00692.x · Cited by 432 · see citing works
Self-citationCesari, M., Kritchevsky, S. B., Baumgartner, R., Atkinson, H. H., Penninx, B. W. J. H., Lenchik, L., Palla, S. L., Ambrosius, W. T., Tracy, R. P., & Pahor, M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.2.428 · Cited by 422 · see citing works
The changing relationship of obesity and disability, 1988–2004
Alley, D. E., & Chang, V. W. (2007) · JAMA · doi:10.1001/jama.298.17.2020 · Cited by 414 · see citing works
Wohlgemuth, S. E., Seo, A. Y., Marzetti, E., Lees, H. A., & Leeuwenburgh, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.002 · Cited by 397 · see citing works
Heilbronn, L. K., Smith, S. R., Martin, C. K., Anton, S. D., & Ravussin, E. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.69 · Cited by 393 · see citing works
Cross-sectional Age Differences in Body Composition in Persons 60 + Years of Age
Baumgartner, R., Stauber, P. M., Mchugh, D., Koehler, K. M., & Garry, P. J. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.6.m307 · Cited by 378 · see citing works
Obesity, Inflammation, and Insulin Resistance – A Mini-Review
Zeyda, M., & Stulnig, T. M. (2009) · Gerontology · doi:10.1159/000212758 · Cited by 365 · see citing works
S ARCOPENIA , W EIGHT L OSS , AND N UTRITIONAL F RAILTY IN THE E LDERLY
Bales, C. W., & Ritchie, C. S. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102715 · Cited by 347 · see citing works
Cesari, M., Kritchevsky, S. B., Baumgartner, R., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.2.428 · Cited by 345 · see citing works
Visser, M., Langlois, J. A., Guralnik, J. M., Cauley, J. A., Kronmal, R. A., Robbins, J., Williamson, J. D., & Harris, T. B. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.3.584 · Cited by 328 · see citing works
Sternfeld, B. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf023 · Cited by 312 · see citing works
Somers, T. J., Keefe, F. J., Pells, J. J., Dixon, K. E., Waters, S. J., Riordan, P. A., Blumenthal, J. A., McKee, D. C., LaCaille, L. J., Tucker, J. M., et al. (2008) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2008.05.009 · Cited by 306 · see citing works
Effect of weight loss and exercise on frailty in obese older adults
Villareal, D. T., Banks, M., Sinacore, D. R., Siener, C., & Klein, S. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.8.860 · Cited by 302 · see citing works
Davidson, L. E., Hudson, R., Kilpatrick, K., Kuk, J. L., McMillan, K., Janiszewski, P. M., Lee, S., Lam, M., & Ross, R. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.558 · Cited by 297 · see citing works
Gender Differences in the Comparison of Self-Reported Disability and Performance Measures
Merrill, S., Seeman, T. E., Kasl, S. V., & Berkman, L. F. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.1.m19 · Cited by 290 · see citing works
Fat and protein redistribution with aging: metabolic considerations
Beaufrère, B., & Morio, B. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601025 · Cited by 289 · see citing works
Exercise and Weight Loss in Obese Older Adults with Knee Osteoarthritis: A Preliminary Study
Messier, S. P., Loeser, R. F., Mitchell, M., Valle, G., Morgan, T., Rejeski, W. J., & Ettinger, W. H. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04781.x · Cited by 287 · see citing works
Cappola, A. R., Xue, Q.-L., Ferrucci, L., Guralnik, J. M., Volpato, S., & Fried, L. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021694 · Cited by 286 · see citing works
Phillips, T., & Leeuwenburgh, C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2870fje · Cited by 283 · see citing works
Pain-related fear and daily functioning in patients with osteoarthritis
Heuts, P. H. T. G., Vlaeyen, J. W. S., Roelofs, J., de Bie, R. A., Aretz, K., van Weel, C., & van Schayck, O. C. P. (2004) · Pain · doi:10.1016/j.pain.2004.03.035 · Cited by 270 · see citing works
Isidori, A. M., Strollo, F., Morè, M., Caprio, M., Aversa, A., Moretti, C., Frajese, G., Riondino, G., & Fabbri, A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.5.6572 · Cited by 268 · see citing works
Perri, M. G., Limacher, M. C., Durning, P. E., Janicke, D. M., Lutes, L. D., Bobroff, L. B., Dale, M. S., Daniels, M. J., Radcliff, T. A., & Martin, A. D. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.21.2347 · Cited by 266 · see citing works
Visser, M., Harris, T. B., Langlois, J. A., Hannan, M. T., Roubenoff, R., Felson, D. T., Wilson, P. W. F., & Kiel, D. P. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.3.m214 · Cited by 259 · see citing works
Lambert, C. P., Wright, N. R., Finck, B. N., & Villareal, D. T. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00006.2008 · Cited by 249 · see citing works
Miller, G. D., Nicklas, B. J., Davis, C., Loeser, R. F., Lenchik, L., & Messier, S. P. (2006) · Obesity · doi:10.1038/oby.2006.139 · Cited by 247 · see citing works
Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia
Burks, T. N., Andrés‐Mateos, E., Marx, R., Mejı́as, R., van Erp, C., Simmers, J. L., Walston, J. D., Ward, C. W., & Cohn, R. D. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002227 · Cited by 246 · see citing works
Insulin resistance: a contributing factor to age-related muscle mass loss?
Guillet, C., & Boirie, Y. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(05)73648-x · Cited by 237 · see citing works
A 3-year longitudinal study on body composition changes in the elderly: Role of physical exercise
Raguso, C. A., Kyle, U. G., Kossovsky, M. P., Roynette, C. E., Paoloni‐Giacobino, A., Hans, D. B., Genton, L., & Pichard, C. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.10.013 · Cited by 234 · see citing works
Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults
FRIMEL, T. N., SINACORE, D. R., & VILLAREAL, D. T. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31816a85ce · Cited by 230 · see citing works
Puthoff, M. L., & Nielsen, D. H. (2007) · Physical Therapy · doi:10.2522/ptj.20060176 · Cited by 229 · see citing works
Fat content in individual muscle fibers of lean and obese subjects.
Malenfant, P., Joanisse, D., Thériault, R., Goodpaster, B., Kelley, D., & Simoneau, J.-A. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801733 · Cited by 227 · see citing works
Zoico, E., Rossi, A. P., Francesco, V. D., Sepe, A., Olioso, D., Pizzini, F. B., Fantin, F., Bosello, O., Cominacini, L., Harris, T. B., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp155 · Cited by 216 · see citing works
van Gool, C. H., Penninx, B. W. J. H., Kempen, G. I. J. M., Rejeski, W. J., Miller, G. D., van Eijk, J. T. M., Pahor, M., & Messier, S. P. (2005) · Arthritis Care & Research · doi:10.1002/art.20902 · Cited by 205 · see citing works
Mantón, K. G. (2007) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.29.020907.090812 · Cited by 201 · see citing works
Relationship Between Fibromyalgia and Obesity in Pain, Function, Mood, and Sleep
Okifuji, A., Donaldson, G. W., Barck, L., & Fine, P. G. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.03.006 · Cited by 192 · see citing works
Henwood, T. R., & Taaffe, D. R. (2005) · Gerontology · doi:10.1159/000082195 · Cited by 192 · see citing works
Sarcopenia of aging: Underlying cellular mechanisms and protection by calorie restriction
Marzetti, E., Lees, H. A., Wohlgemuth, S. E., & Leeuwenburgh, C. (2009) · BioFactors · doi:10.1002/biof.5 · Cited by 182 · see citing works
Focht, B. C., Rejeski, W. J., Ambrosius, W. T., Katula, J. A., & Messier, S. P. (2005) · Arthritis Care & Research · doi:10.1002/art.21466 · Cited by 175 · see citing works
Frailty and muscle metabolism dysregulation in the elderly
Evans, W. J., Paolisso, G., Abbatecola, A. M., Corsonello, A., Bustacchini, S., Strollo, F., & Lattanzio, F. (2010) · Biogerontology · doi:10.1007/s10522-010-9297-0 · Cited by 173 · see citing works
Lamb, S. E., Guralnik, J., Buchner, D., Ferrucci, L., Hochberg, M., Simonsick, E., & Fried, L. (2000) · Annals of the Rheumatic Diseases · doi:10.1136/ard.59.5.331 · Cited by 172 · see citing works
Physical activity, cardiorespiratory fitness, and adiposity: contributions to disease risk
LaMonte, M. J., & Blair, S. N. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000241662.92642.08 · Cited by 171 · see citing works
Rolland, Y., Lauwers‐Cancès, V., Pahor, M., Fillaux, J., Grandjean, H., & Vellas, B. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.552 · Cited by 168 · see citing works
Obesity and Functional Disability in Elderly Americans
Chen, H., & Guo, X. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01624.x · Cited by 167 · see citing works
Lim, J., Tchai, E., & Jang, S. (2010) · PM&R · doi:10.1016/j.pmrj.2010.04.004 · Cited by 167 · see citing works
Vincent, H. K., Bourguignon, C. M., & Vincent, K. R. (2006) · Obesity · doi:10.1038/oby.2006.224 · Cited by 155 · see citing works
Self-citationSkeletal muscle proteolysis in aging
Combaret, L., Dardevet, D. P., Béchet, D., Taillandier, D., Mosoni, L., & Attaix, D. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831b9c31 · Cited by 152 · see citing works
Sedentarism affects body fat mass index and fat-free mass index in adults aged 18 to 98 years
Kyle, U. G., Morabia, A., Schutz, Y., & Pichard, C. (2004) · Nutrition · doi:10.1016/j.nut.2003.11.019 · Cited by 142 · see citing works
Avila, J. J., Gutierres, J. A., Sheehy, M. E., Lofgren, I. E., & Delmonico, M. J. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1387-9 · Cited by 128 · see citing works
Beyond atrophy: redox mechanisms of muscle dysfunction in chronic inflammatory disease
Reid, M. B., & Moylan, J. S. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.203356 · Cited by 126 · see citing works
Obesity Profiles with Knee Osteoarthritis: Correlation with Pain, Disability, Disease Progression
Marks, R. (2007) · Obesity · doi:10.1038/oby.2007.221 · Cited by 119 · see citing works
Bouchard, D. R., Soucy, L., Sénéchal, M., Dionne, I. J., & Brochu, M. (2009) · Menopause · doi:10.1097/gme.0b013e31817dacf7 · Cited by 117 · see citing works
Lebrun, C. E. I., van der Schouw, Y. T., de Jong, F. H., Grobbee, D. E., & Lamberts, S. W. J. (2006) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000222331.23478.ec · Cited by 112 · see citing works
Waters, D. L., Qualls, C. R., Dorin, R. I., Veldhuis, J. D., & Baumgartner, R. N. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.5.536 · Cited by 112 · see citing works
Ability of Fat and Fat-Free Mass Percentages to Predict Functional Disability in Older Men and Women
Broadwin, J., Goodman‐Gruen, D., & Slymen, D. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.t01-1-49273.x · Cited by 103 · see citing works
Chen, S.-C., Ueng, K., Lee, S.-H., Sun, K.-T., & Lee, M.-C. (2010) · Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2009.0560 · Cited by 102 · see citing works
Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle
McKiernan, S. H., Colman, R. J., Lopez, M. E., Beasley, T. M., Aiken, J. M., Anderson, R. M., & Weindruch, R. H. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.011 · Cited by 94 · see citing works
Ramsay, S. E., Whincup, P. H., Shaper, A. G., & Wannamethee, S. G. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj217 · Cited by 94 · see citing works
Upper and lower limb functionality: Are these compromised in obese children?
Riddiford‐Harland, D. L., Steele, J. R., & Baur, L. A. (2006) · International Journal of Pediatric Obesity · doi:10.1080/17477160600586606 · Cited by 92 · see citing works
Duvigneaud, N., Matton, L., Wijndaele, K., Deriemaeker, P., Lefevre, J., Philippaerts, R. M., Thomis, M. A., Delecluse, C., & Duquet, W. (2008) · PubMed · Cited by 86 · see citing works
Sarcopenic obesity: satellite cells in the aging muscle
Thornell, L.-E. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3283412260 · Cited by 86 · see citing works
Is There A Relationship Between Insulin Resistance and Frailty Syndrome?
Paolisso, G., & Abbatecola, A. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208783497750 · Cited by 85 · see citing works
Kelly, K. R., Haus, J. M., Solomon, T. P. J., Patrick-Melin, A. J., Cook, M. D., Rocco, M. B., Barkoukis, H. D., & Kirwan, J. P. (2011) · Journal of Nutrition · doi:10.3945/jn.111.139964 · Cited by 83 · see citing works
Anton, S. D., Manini, T. M., Milsom, V. A., Dubyak, P. J., Cesari, M., Cheng, J., Daniels, M. J., Marsiske, M., Pahor, M., Leeuwenburgh, C., et al. (2011) · Clinical Interventions in Aging · doi:10.2147/cia.s17001 · Cited by 83 · see citing works
Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading
Peterson, J. M., Bryner, R. W., & Alway, S. E. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00073.2008 · Cited by 81 · see citing works
Vincent, H. K., Omli, M. R., Day, T., Hodges, M. J., Vincent, K. R., & George, S. Z. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.01011.x · Cited by 80 · see citing works
Self-citationAbility of Fat and Fat‐Free Mass Percentages to Predict Functional Disability in Older Men and Women
Broadwin, J., Goodman‐Gruen, D., & Slymen, D. (2001) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2001.49273.x · Cited by 79 · see citing works
Toward a Definition of Sarcopenia
Cederholm, T., Bauer, J. M., Boirie, Y., Schneider, S. M., Sieber, C. C., & Rolland, Y. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.04.001 · Cited by 78 · see citing works
Sarcopenic Obesity: An Emerging Cause of Frailty in Older Adults
Jarosz, P. A., & Bellar, A. (2008) · Geriatric Nursing · doi:10.1016/j.gerinurse.2008.02.010 · Cited by 75 · see citing works
Modulation of the actomyosin interaction during fatigue of skeletal muscle
Cooke, R. (2007) · Muscle & Nerve · doi:10.1002/mus.20891 · Cited by 73 · see citing works
Vincent, H., Lamb, K. M., Day, T. I., Tillman, S. M., Vincent, K., & George, S. (2010) · PM & R : the journal of injury, function, and rehabilitation · doi:10.1016/j.pmrj.2010.04.027 · Cited by 73 · see citing works
Self-citationSmits, J. A. J., Tart, C. D., Presnell, K. E., Rosenfield, D., & Otto, M. W. (2009) · Cognitive Behaviour Therapy · doi:10.1080/16506070902915261 · Cited by 71 · see citing works
Effects of Exercise on Mobility in Obese and Nonobese Older Adults
Manini, T. M., Newman, A. B., Fielding, R. A., Blair, S. N., Perri, M. G., Anton, S. D., Goodpaster, B., Katula, J. A., Rejeski, W. J., Kritchevsky, S. B., et al. (2009) · Obesity · doi:10.1038/oby.2009.317 · Cited by 66 · see citing works
Seidman, S. N., & MD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4150 · Cited by 59 · see citing works
Grant, S., Todd, K., Aitchison, T. C., Kelly, P., & Stoddart, D. (2003) · Public Health · doi:10.1016/s0033-3506(03)00131-8 · Cited by 58 · see citing works
Schlenk, E. A., Lias, J. L., Sereika, S. M., Dunbar‐Jacob, J. M., & Kwoh, K. C. (2011) · Rehabilitation Nursing · doi:10.1002/j.2048-7940.2011.tb00063.x · Cited by 57 · see citing works
Somers, T. J., Keefe, F. J., Carson, J. W., Pells, J. J., & LaCaille, L. J. (2008) · Pain Research and Management · doi:10.1155/2008/652453 · Cited by 56 · see citing works
Pain and Disability in Older Mexican‐American Adults
Weaver, G. D., Kuo, Y., Raji, M. A., Snih, S. A., Ray, L., Torres, E., & Ottenbacher, K. J. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02263.x · Cited by 56 · see citing works
(2011) · Nutrition Today · doi:10.1097/nt.0b013e31822acb50 · Cited by 42 · see citing works
Relationships between leisure-time physical activity, obesity and disability in elderly men
Francesco, V. D., Zamboni, M. M., Zoico, E., Bortolani, A., Maggi, S., Bissoli, L., Zivelonghi, A., Guariento, S., & Bosello, O. (2005) · Aging Clinical and Experimental Research · doi:10.1007/bf03324597 · Cited by 41 · see citing works
Dutheil, F., Lesourd, B., Courteix, D., Chapier, R., Doré, É., & Lac, G. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-148 · Cited by 35 · see citing works
藤井, 舜., Kritchevsky, S. B., Leeuwenburgh, C., & 中山, 雄. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.609 · Cited by 31 · see citing works
Disuse Atrophy of Human Skeletal Muscle
Urso, M. L. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181a6458a · Cited by 28 · see citing works
Ambulatory Activity and Body Mass Index in White and Non-White Older Adults
Swartz, A. M., Strath, S. J., Parker, S., Miller, N. E., & Cieslik, L. J. (2007) · Journal of Physical Activity and Health · doi:10.1123/jpah.4.3.294 · Cited by 21 · see citing works
The experience of being disabled and obese
Pain, H., & Wiles, R. (2006) · Disability and Rehabilitation · doi:10.1080/09638280600554561 · Cited by 21 · see citing works
B̀ouchard, D. R., Soucy, L., Sénéchal, M., Dionne, I. J., & Brochu, M. (2010) · Journal of Women & Aging · doi:10.1080/08952840903489011 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Physical activity is medicine for older adults
Taylor, D. (2013) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2012-131366 · Cited by 541 · see citing works
TGF-β Signaling in Cellular Senescence and Aging-Related Pathology
Tominaga, K., & Suzuki, H. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205002 · Cited by 393 · see citing works
Locomotive Syndrome: Definition and Management
Nakamura, K., & Ogata, T. (2016) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-016-9208-2 · Cited by 311 · see citing works
Skeletal muscle depletion is an independent prognostic factor for hepatocellular carcinoma
Iritani, S., Imai, K., Takai, K., Hanai, T., Ideta, T., Miyazaki, T., Suetsugu, A., Shiraki, M., Shimizu, M., & Moriwaki, H. (2014) · Journal of Gastroenterology · doi:10.1007/s00535-014-0964-9 · Cited by 247 · see citing works
Yoshimura, N., Muraki, S., Oka, H., Iidaka, T., Kodama, R., Kawaguchi, H., Nakamura, K., Tanaka, S., & Akune, T. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3823-0 · Cited by 201 · see citing works
Liao, C.-D., Tsauo, J.-Y., Lin, L.-F., Huang, S.-W., Ku, J.-W., Chou, L.-C., & Liou, T.-H. (2017) · Medicine · doi:10.1097/md.0000000000007115 · Cited by 201 · see citing works
Liao, C.-D., Tsauo, J.-Y., Huang, S.-W., Ku, J.-W., Hsiao, D.-J., & Liou, T.-H. (2018) · Scientific Reports · doi:10.1038/s41598-018-20677-7 · Cited by 180 · see citing works
Prevalence and factors associated with sarcopenia in patients with rheumatoid arthritis
Torii, M., Hashimoto, M., Hanai, A., Fujii, T., Furu, M., Ito, H., Uozumi, R., Hamaguchi, M., Terao, C. C., Yamamoto, W., et al. (2018) · Modern Rheumatology · doi:10.1080/14397595.2018.1510565 · Cited by 177 · see citing works
Sarcopenic obesity in aging population: current status and future directions for research
Kohara, K. (2014) · Endocrine · doi:10.1007/s12020-013-9992-0 · Cited by 171 · see citing works
Freiberger, E., Goisser, S., Porzel, S., Volkert, D., Kemmler, W., Sieber, C., & Bollheimer, C. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s82454 · Cited by 162 · see citing works
Nicklas, B. J., Chmelo, E., Delbono, O., Carr, J. J., Lyles, M. F., & Marsh, A. P. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.105270 · Cited by 144 · see citing works
Kim, T. N., Park, M. S., Ryu, J. Y., Choi, H. Y., Hong, H. C., Yoo, H. J., Kang, H. J., Song, W., Park, S. W., Baik, S. H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115407 · Cited by 133 · see citing works
Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
Pándics, T., Major, D., Fazekas‐Pongor, V., Szarvas, Z., Péterfi, A., Mukli, P., Gulej, R., Ungvari, A., Fekete, M., Tompa, A., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00913-3 · Cited by 128 · see citing works
Csapo, R., Malis, V., Sinha, U. S., Du, J., & Sinha, S. (2014) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-15-209 · Cited by 125 · see citing works
Vincent, H., Zdziarski, L., & Wasser, J. (2015) · Journal of Pain Research · doi:10.2147/jpr.s55360 · Cited by 121 · see citing works
Self-citationScott, D. S., Daly, R. M., Sanders, K. M., & Ebeling, P. R. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0274-z · Cited by 119 · see citing works
The contribution of postural balance analysis in older adult fallers: A narrative review
Pizzigalli, L., Cremasco, M. M., Mulasso, A., & Rainoldi, A. (2015) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2015.12.008 · Cited by 101 · see citing works
Anton, S. D., Karabetian, C., Naugle, K., & Buford, T. W. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.06.007 · Cited by 100 · see citing works
Vasconcelos, K. S. S., Dias, J. M. D., Araújo, M. C., Pinheiro, A. C., Moreira, B. S., & Dias, R. C. (2016) · Brazilian Journal of Physical Therapy · doi:10.1590/bjpt-rbf.2014.0174 · Cited by 97 · see citing works
Sarcopenia is a risk factor for the recurrence of hepatocellular carcinoma after curative treatment
Kamachi, S., Mizuta, T., Otsuka, T., Nakashita, S., Ide, Y., Miyoshi, A., Kitahara, K., Eguchi, Y., Ozaki, I., & Anzai, K. (2015) · Hepatology Research · doi:10.1111/hepr.12562 · Cited by 96 · see citing works
Liao, C.-D., Lee, P.-H., Hsiao, D.-J., Huang, S.-W., Tsauo, J.-Y., Chen, H.-C., & Liou, T.-H. (2018) · Nutrients · doi:10.3390/nu10121916 · Cited by 94 · see citing works
Applications of Medium-Chain Triglycerides in Foods
Watanabe, S., & Tsujino, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.802805 · Cited by 102 · see citing works
Ishak, N. A., Zahari, Z., & Justine, M. (2017) · Pain Research and Treatment · doi:10.1155/2017/3489617 · Cited by 84 · see citing works
Yamada, Y., Tada, M., Mandai, K., Hidaka, N., Inui, K., & Nakamura, H. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-04929-4 · Cited by 80 · see citing works
Musculoskeletal Pain, Fear Avoidance Behaviors, and Functional Decline in Obesity
Vincent, H. K., Adams, M. C. B., Vincent, K. R., & Hurley, R. W. (2013) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000013 · Cited by 77 · see citing works
Self-citationHashimoto, Y., Osaka, T., Fukuda, T., Tanaka, M., Yamazaki, M., & Fukui, M. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0124 · Cited by 72 · see citing works
Body Mass Index and Risk for Clinical Lumbar Spinal Stenosis
Knutsson, B., Sandén, B., Sjödén, G., Järvholm, B., & Michaëlsson, K. (2015) · Spine · doi:10.1097/brs.0000000000001038 · Cited by 67 · see citing works
Alexander, L., Christensen, S. M., Richardson, L., Ingersoll, A. B., Burridge, K., Golden, A., Karjoo, S., Cortez, D., Shelver, M., & Bays, H. E. (2022) · Obesity Pillars · doi:10.1016/j.obpill.2021.100005 · Cited by 61 · see citing works
Imai, K., Takai, K., Watanabe, S., Hanai, T., Suetsugu, A., Shiraki, M., & Shimizu, M. (2017) · Nutrients · doi:10.3390/nu9101054 · Cited by 57 · see citing works
Pozzobon, D., Ferreira, P. H., Dario, A. B., Almeida, L., Vesentini, G., Harmer, A. R., & Ferreira, M. L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212030 · Cited by 56 · see citing works
The Impact of Obesity and Exercise on Cognitive Aging
Chan, J. S. Y., Yan, J. H., & Payne, V. G. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00097 · Cited by 52 · see citing works
Okamura, H., Ishikawa, K., Kudo, Y., Matsuoka, A., Maruyama, H., Emori, H., Yamamura, R., Hayakawa, C., Tani, S., Tsuchiya, K., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237454 · Cited by 51 · see citing works
Tada, M., Yamada, Y., Mandai, K., & Hidaka, N. (2018) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13335 · Cited by 50 · see citing works
Tanaka, M., Okada, H., Hashimoto, Y., Kumagai, M., Nishimura, H., Oda, Y., & Fukui, M. (2019) · Liver International · doi:10.1111/liv.14253 · Cited by 45 · see citing works
Yang, B., Tang, C., Shi, Z., & Gao, L. (2023) · Nutrients · doi:10.3390/nu15102307 · Cited by 43 · see citing works
Influences of Resistance Training on Physical Function in Older, Obese Men and Women With Sarcopenia
Stoever, K., Heber, A., Eichberg, S., & Brixius, K. (2016) · Journal of Geriatric Physical Therapy · doi:10.1519/jpt.0000000000000105 · Cited by 45 · see citing works
Márquez, D. X., Wilbur, J., Hughes, S. L., Berbaum, M. L., Wilson, R. S., Büchner, D. M., & McAuley, E. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.06.012 · Cited by 40 · see citing works
Which osteoarthritic gait features recover following total knee replacement surgery?
Biggs, P., Whatling, G. M., Wilson, C., Metcalfe, A. J., & Holt, C. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0203417 · Cited by 40 · see citing works
Inflammatory and Oxidative Stress Markers in Skeletal Muscle of Obese Subjects
Catalán, V., Frühbeck, G., & Gómez‐Ambrosi, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812504-5.00008-8 · Cited by 43 · see citing works
Circuit Training Improvements in Korean Women with Sarcopenia
Jung, W., Kim, Y.-Y., & Park, H. (2019) · Perceptual and Motor Skills · doi:10.1177/0031512519860637 · Cited by 41 · see citing works
Moreno-Vecino, B., Arija-Blázquez, A., Pedrero-Chamizo, R., Alcazar, J., Gómez-Cabello, A., Pérez-López, F., González-Gross, M., Casajús, J., & Ara, I. (2015) · Maturitas · doi:10.1016/j.maturitas.2015.07.008 · Cited by 28 · see citing works
Horii, N., Sawda, Y., Kumamoto, T., Tsuchiya, N., Murakami, T., Yabushita, Y., Honma, Y., Matsuyama, R., Morioka, D., Akiyama, H., et al. (2020) · World Journal of Surgical Oncology · doi:10.1186/s12957-020-01836-5 · Cited by 37 · see citing works
Caloric Restriction for Treatment of Geriatric Obesity: Do the Benefits Outweigh the Risks?
Normandin, É., Houston, D. K., & Nicklas, B. J. (2015) · Current Nutrition Reports · doi:10.1007/s13668-015-0123-9 · Cited by 35 · see citing works
Teaching the body: a systematic review of posture interventions in primary schools
Dugan, J. (2017) · Educational Review · doi:10.1080/00131911.2017.1359821 · Cited by 35 · see citing works
Implication of diet and exercise on the management of age‐related sarcopenic obesity in Asians
Kim, Y. J., Moon, S., Yu, J. M., & Chung, H. S. (2022) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14442 · Cited by 33 · see citing works
The effects of obesity, age, and relative workload levels on handgrip endurance
Mehta, R. K., & Cavuoto, L. A. (2014) · Applied Ergonomics · doi:10.1016/j.apergo.2014.07.007 · Cited by 33 · see citing works
Macek, P., Terek-Derszniak, M., Biskup, M., Król, H., Smok-Kalwat, J., Góźdź, S. S., & Žák, M. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s277171 · Cited by 33 · see citing works
Løbo, R. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00014-7 · Cited by 32 · see citing works
Mitochondrial Dysfunction and Sarcopenic Obesity: The Role of Exercise
Hadjispyrou, S., Giannopoulos, A., Philippou, Α., & Theos, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12175628 · Cited by 30 · see citing works
Musculoskeletal Function and Obesity: Implications for Physical Activity
Shultz, S. P., Byrne, N. M., & Hills, A. P. (2014) · Current Obesity Reports · doi:10.1007/s13679-014-0107-x · Cited by 31 · see citing works
Makiel, K., Suder, A., Targosz, A., Maciejczyk, M., & Haim, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12010369 · Cited by 30 · see citing works
Jung, W.-S., Kim, Y.-Y., Kim, J.-W., & Park, H.-Y. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2304134 · Cited by 30 · see citing works
Moreno‐Navarrete, J. M., Blasco, G., Xifra, G., Karczewska‐Kupczewska, M., Stefanowicz, M., Matulewicz, N., Puig, J., Ortega, F. J., Ricart, W., Strączkowski, M., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3303 · Cited by 27 · see citing works
Sbardelotto, M. L., Costa, R. R., Malysz, K. A., Pedroso, G. S., Pereira, B. C., Sorato, H. R., Silveira, P. C. L., Nesi, R. T., Grande, A. J., & Pinho, R. A. (2019) · Clinics · doi:10.6061/clinics/2019/e833 · Cited by 27 · see citing works
Were, J. M., Stranges, S., & Creed, I. F. (2020) · Journal of Global Health · doi:10.7189/jogh.10.020423 · Cited by 28 · see citing works
Strategies to improve diet in older adults
Johnson, M. A. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112002819 · Cited by 26 · see citing works
How to Train Your Health: Sports as a Resource to Improve Cognitive Abilities in Cancer Patients
Sebri, V., Savioni, L., Triberti, S., Mazzocco, K., & Pravettoni, G. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02096 · Cited by 27 · see citing works
Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice
Yoshikawa, M., Hosokawa, M., Miyashita, K., Nishino, H., & Hashimoto, T. (2021) · Nutrients · doi:10.3390/nu13041079 · Cited by 25 · see citing works
Martin, D. J., Maeder, Y., Kobayashi, K., Schneider, M. H., Koerfer, J., Melloul, E., Halkic, N., Hübner, M., Demartines, N., Becce, F., et al. (2022) · Cancers · doi:10.3390/cancers14010261 · Cited by 25 · see citing works
Dong, D., Shi, J.-Y., Shang, X., Liu, B., Xu, W.-L., Cui, G.-Z., & Wang, N.-Y. (2022) · Medicine · doi:10.1097/md.0000000000028680 · Cited by 25 · see citing works
Sarcopenia and inflammation in patients undergoing hemodialysis
Hortegal, E. V., Alves, J. D. D. A., Santos, E. J. F., Nunes, L. C. R., Galvão, J. C., Nunes, R. F., Lula, D. D. A., de Carvalho, S. C. R., França, A. K. T. D. C., Santos, E. M. D., et al. (2020) · Nutrición Hospitalaria · doi:10.20960/nh.03068 · Cited by 24 · see citing works
Whaikid, P., & Piaseu, N. (2023) · International Journal of Nursing Sciences · doi:10.1016/j.ijnss.2023.11.002 · Cited by 23 · see citing works
Imai, K., Takai, K., Maeda, T., Watanabe, S., Hanai, T., Suetsugu, A., Shiraki, M., & Shimizu, M. (2018) · Oncotarget · doi:10.18632/oncotarget.24500 · Cited by 23 · see citing works
Aibar‐Almazán, A., Martínez‐Amat, A., Cruz‐Díaz, D., la Torre‐Cruz, M. J. D., Jiménez‐García, J. D., Zagalaz‐Anula, N., Peiró, M. T. R., de Guevara, N. M.-L., & Hita‐Contreras, F. (2020) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003790 · Cited by 23 · see citing works
Obesity and Mobility in Advancing Age: Mechanisms and Interventions to Preserve Independent Mobility
Vincent, H. K., & Mathews, A. (2013) · Current Obesity Reports · doi:10.1007/s13679-013-0059-6 · Cited by 22 · see citing works
Self-citationMinematsu, A., Hazaki, K., Harano, A., Okamoto, N., & Kurumatani, N. (2015) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2015.05.009 · Cited by 21 · see citing works
Lippi, L., Alessandro de, S. I. R. E., Folli, A., Turco, A., Moalli, S., Marcasciano, M., Ammendolia, A., & Invernizzi, M. (2024) · Cancers · doi:10.3390/cancers16030521 · Cited by 19 · see citing works
Patterns of Chronic Conditions and Their Associations With Behaviors and Quality of Life, 2010.
Barile, J. P., Mitchell, S. A., Thompson, W., Zack, M. M., Reeve, B. B., Cella, D. F., & Smith, A. W. (2015) · PubMed Central · doi:10.5888/pcd12.150179 · Cited by 19 · see citing works
Zhuang, M., Jin, M., Lu, T., Lu, L., Ainsworth, B. E., Liu, Y., & Chen, N. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.917525 · Cited by 18 · see citing works
Banger, M. S., Doonan, J., Jones, B. G., MacLean, A. D., Rowe, P. J., & Blyth, M. (2022) · The Bone & Joint Journal · doi:10.1302/0301-620x.104b4.bjj-2021-0837.r1 · Cited by 17 · see citing works
EFECTOS DEL EJERCICIO FÍSICO EN LA CONDICIÓN FÍSICA FUNCIONAL Y LA ESTABILIDAD EN ADULTOS MAYORES
Claros, J. A. V., Cruz, M. V. Q., & Beltrán, Y. H. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 17 · see citing works
Hillman, A. R., Taylor, B. C. R., & Thompkins, D. M. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.12.026 · Cited by 17 · see citing works
Wang, Y., Tian, F., Qian, Z. M., Ran, S., Zhang, J., Wang, C., Chen, L., Zheng, D., Vaughn, M. G., Tabet, M., et al. (2024) · Nutrients · doi:10.3390/nu16203553 · Cited by 15 · see citing works
Nutritional Considerations in Preventing Muscle Atrophy
Creţoiu, S. M., & Zugravu, C. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1435-3_23 · Cited by 16 · see citing works
Osiński, W., & Kantanista, A. (2017) · PubMed Central · doi:10.34763/devperiodmed.20172103.224234 · Cited by 15 · see citing works
Kayano, H., Nomura, E., Abe, R., Ueda, Y., Machida, T., Fujita, C., Uchiyama, S., Endo, K., Murakami, K., Mukai, M., et al. (2019) · BMC Surgery · doi:10.1186/s12893-019-0629-y · Cited by 15 · see citing works
Effects of thiol antioxidant β-mercaptoethanol on diet-induced obese mice
Wong, S. L., Kirkland, J. L., Schwanz, H. A., Simmons, A. L., Hamilton, J. A., Corkey, B. E., & Guo, W. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.04.031 · Cited by 15 · see citing works
Sharma, N., Chahal, A., Balasubramanian, K., Sanjeevi, R. R., Rai, R. H., Bansal, N., Muthukrishnan, R., & Sharma, A. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01283-5 · Cited by 14 · see citing works
Suder, A., Makiel, K., Targosz, A., Maciejczyk, M., Kosowski, P., & Haim, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-51473-1 · Cited by 13 · see citing works
Obesity-Related Inflammation: Implications for Older Adults
Ellis, A. C., Crowe, K. M., & Lawrence, J. C. (2013) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2013.842199 · Cited by 13 · see citing works
Barrero, L. H., & Caban-Martinez, A. J. (2015) · doi:10.1093/med/9780199661756.003.0209 · Cited by 13 · see citing works
Johnson, M. A., & Bales, C. W. (2014) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2014.875817 · Cited by 13 · see citing works
Chen, Y., Zong, H.-X., Xu, S., Chu, Y.-R., Wang, J., Li, W.-J., & Chen, K. (2021) · Clinical Rheumatology · doi:10.1007/s10067-021-05703-w · Cited by 12 · see citing works
Shen, S., Chu, J., Cheng, L., Zeng, X., He, T., Xu, L., Li, J.-R., & Chen, X. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012140 · Cited by 12 · see citing works
Heck, S. O., Fulco, B. C. W., Quines, C. B., Oliveira, C. E. S., Leite, M. R., Cechella, J. L., & Nogueira, C. W. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25819 · Cited by 11 · see citing works
Determinants of Obesity in West Africa: A Systematic ReviewPreprint
Agyemang, K., Pokhrel, S., Victor, C. R., & Anokye, N. (2021) · medRxiv · doi:10.1101/2021.04.27.21255462 · Cited by 11 · see citing works
Galvan, M. J., Sanchez, M. J., McAinch, A. J., Covington, J. D., Boyle, J. B., & Bajpeyi, S. (2022) · Endocrine Connections · doi:10.1530/ec-21-0533 · Cited by 10 · see citing works
Dedov, V. N., & Dedova, I. V. (2015) · Telemedicine Journal and e-Health · doi:10.1089/tmj.2014.0163 · Cited by 10 · see citing works
Effectiveness of in-patient rehabilitation in obesity-related orthopedic conditions.
Capodaglio, P., Cimolin, V., Tacchini, E., Precilios, H., & Brunani, A. (2013) · PubMed · doi:10.3275/8897 · Cited by 10 · see citing works
Juzentaihoto Suppresses Muscle Atrophy in KKAy Mice
Ishida, T., Jobu, K., Morisawa, S., Kawada, K., Yoshioka, S., & Miyamura, M. (2022) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b22-00039 · Cited by 9 · see citing works
Al‐Radaideh, A., Tayyem, R., Al-Fayomi, K. I., Nimer, N. A., Almomani, A., Alhajjaj, S., Agraib, L. M., & Hijjawi, N. (2019) · British Journal of Biomedical Science · doi:10.1080/09674845.2019.1571555 · Cited by 9 · see citing works
Relationship between Abdominal Obesity and Proportion of Supper and Late-night Meals
Na, S.-K., Cheon, S.-H., Choi, Y. J., Lee, H., Roh, Y.-K., & Choi, M.-K. (2016) · The Korean Journal of Obesity · doi:10.7570/kjo.2016.25.2.92 · Cited by 9 · see citing works
Nakano, R., Takebe, N., Ono, M., Hangai, M., Nakagawa, R., Yashiro, S., Murai, T., Nagasawa, K., Takahashi, Y., Satoh, J., et al. (2017) · Obesity Science & Practice · doi:10.1002/osp4.97 · Cited by 8 · see citing works
Isaka, M., Sugimoto, K., Akasaka, H., Yasunobe, Y., Takahashi, T., Keyu, X., Onishi, Y., Yoshida, S., Minami, T., Yamamoto, K. I., et al. (2022) · Clinical Interventions in Aging · doi:10.2147/cia.s385469 · Cited by 8 · see citing works
Exercise-induced changes of gene expression in the cerebellum of aged mice
Lee, M. C., Cho, H.-S., Yoon, K. J., Lee, W., & Moon, H. Y. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.024 · Cited by 8 · see citing works
Sabol, V. K., Kennerly, S. M., Alderden, J., Horn, S. D., & Yap, T. L. (2020) · Wound Management & Prevention · doi:10.25270/wmp.2020.5.1829 · Cited by 8 · see citing works
Ayyıldız, A. Ç., Yılmaz, F., Altındaş, H., İnceoğlu, S. Ç., & Kuran, B. (2023) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000002283 · Cited by 7 · see citing works
Xing, Y., Zheng, Y., Liu, Y., Han, P., Chen, X., Zhang, N., Ni, Y., Zhou, Z., & Guo, Q. (2024) · Medicine · doi:10.1097/md.0000000000038396 · Cited by 7 · see citing works
Nishizaki, Y., Shimada, K., Tani, S., Ogawa, T., Ando, J., Takahashi, M., Yamamoto, M., Shinozaki, T., Miyazaki, T., Miyauchi, K., et al. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01445-w · Cited by 7 · see citing works
Zhao, Y., Becce, F., Balmer, R., do Amaral, R. H., Alemán‐Gómez, Y., Uldry, É., Fraga, M. C., Tsoumakidou, G., Villard, N., Denys, A. L., et al. (2025) · European Radiology · doi:10.1007/s00330-025-11349-y · Cited by 6 · see citing works
- Authors
- Vincent, H. K., Raiser, S. N., & Vincent, K. R.
- Affiliations
- University of Florida Health (US)
- Corresponding author
- Vincent, Heather K.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 11
- Issue
- 3
- Pages
- 361-373
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC3356456
- OpenAlex
- W2135470739
- Cited by
- 186
- References
- 115
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 10 · 2023: 13 · 2022: 17 · 2021: 10 · 2020: 15 · 2019: 13 · 2018: 10 · 2017: 10 · 2016: 13 · 2015: 19 · 2014: 11 · 2013: 18 · 2012: 3
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000064)
- National Institute on Aging (P30AG028740)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (#AR057552-01A1, R03AR057552)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- sarcopenic obesity, aging, obesity, exercise training, resistance training, caloric restriction, muscle mass loss, functional performance, mobility impairment, multimodal training, inflammation, oxidative stress, insulin resistance, older adults, aerobic exercise
- MeSH terms
- Aging, Animals, Humans, Motor Activity, Musculoskeletal System, Obesity, Osteoporosis, Weight Loss, Exercise, Randomized Controlled Trials as Topic, Muscle Strength, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
