Sodium Decanoate Improves Intestinal Epithelial Barrier and Antioxidation via Activating G Protein-Coupled Receptor-43
Open accessAbstract
The study was conducted to explore actions of decanoic acid on regulating intestinal barrier and antioxidant functions in intestinal epithelium cells isolated from porcine jejunum (IPEC-J2) and C57/BL6 mice models. In vitro and vivo assays, mice and IPEC-J2 cells treated by H2O2 were disposed of sodium decanoate and sodium butyrate to determine intestinal barrier and antioxidant functions of the host. Results showed that sodium decanoate upregulated expression of tight junction proteins and improved antioxidant capacity in both IPEC-J2 cells treated by H2O2 and mice models (p < 0.05). Sodium decanoate increased weight gain and ileal villus height of mice compared with control and sodium butyrate treatments (p < 0.05). Sodium decanoate increased α-diversity of ileal microbiota, volatile fatty acids concentration, and G protein-coupled receptor-43 (GPR-43) expression in the ileum and colon of mice (p < 0.05). In conclusion, sodium decanoate improved antioxidant capacity, intestinal morphology, and gut physical barrier of intestinal epithelial cells, resulting in an increase growth performance of mice, which is mediated through activating GPR-43 signaling.
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Butyrate exerts anti-inflammatory and anti-oxidant effects while repairing the intestinal barrier.
“Butyrate exerts anti-inflammatory and [18] anti-oxidant effects [19] while repairing the intestinal barrier [20].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [19]
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Guo, T.-T., Zhang, Z., Sun, Y., Zhu, R.-Y., Wang, F.-X., Ma, L.-J., Jiang, L., & Liu, H.-D. (2023) · Nutrients · doi:10.3390/nu15040930 · Cited by 82 · see citing works
- Authors
- Zhao, J., Hu, J., & Ma, X.
- Affiliations
- State Key Laboratory of Animal Nutrition (CN)
- Corresponding author
- Ma, Xi
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-08-11
- Volume
- 13
- Issue
- 8
- Pages
- 2756
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC8401944
- OpenAlex
- W3187331107
- Cited by
- 17
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 5
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31930106;31829004;31722054)
- National Key R&D Program of China (2018YFD0500601)
- 2115 Talent Development Program of China Agricultural University (1041-00109019)
- 111 Project (B16044)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- sodium decanoate, capric acid, intestinal barrier, tight junction proteins, antioxidant capacity, oxidative stress, sodium butyrate, intestinal epithelial cells, ileal microbiota, volatile fatty acids, growth performance
- MeSH terms
- Gastrointestinal Microbiome, Animals, Antioxidants, Colon, Decanoic Acids, Epithelial Cells, Ileum, Intestinal Mucosa, Jejunum, Swine, Signal Transduction, Up-Regulation, Tight Junctions, Butyric Acid, Models, Animal, Receptors, G-Protein-Coupled, Mice
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