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Cited by 33

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial

Deshmukh, Harshal, Papageorgiou, Maria, Wells, Liz, Akbar, Shahzad, Strudwick, Thomas, Deshmukh, Ketki, Vitale, Salvatore Giovanni, Rigby, Alan, Vince, Rebecca V., Reid, Marie, Sathyapalan, Thozhukat·2023·Nutrients
DOI 10.3390/nu15183872
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Abstract

We performed an open-label, randomised controlled trial to compare the effects of a very-low-calorie diet (VLCD) vs. moderate energy deficit approach on body weight, body composition, free androgen index (FAI), and metabolic markers in obese women with polycystic ovary syndrome (PCOS). Forty eligible patients were randomly assigned to a VLCD (n = 21) or a conventional energy deficit approach (n = 19) over the same period. After eight weeks, both groups experienced significant weight loss; however, this was greater in the VLCD arm (−10.9% vs. −3.9%, p < 0.0001). There was also a trend towards a reduction in FAI in the VLCD group compared to the energy deficit group (−32.3% vs. −7.7%, p = 0.07). In the VLCD arm, two women (18%) had a biochemical remission of PCOS (FAI < 4); this was not the case for any of the participants in the energy deficit arm. There was a significant within-group increase in the sex-hormone-binding globulin (p = 0.002) and reductions in fasting blood glucose (p = 0.010) and waist to hip ratio (p = 0.04) in the VLCD arm, but not in the energy deficit arm. The VLCD resulted in significantly greater weight reduction and was accompanied by more pronounced improvements in hyperandrogenaemia, body composition, and several metabolic parameters in obese women with PCOS as compared to the energy deficit approach.

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Citations

Cites

Research works printed but not linked: 28

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Metadata

Authors
Deshmukh, H., Papageorgiou, M., Wells, L., Akbar, S., Strudwick, T., Deshmukh, K., Vitale, S. G., Rigby, A., Vince, R. V., Reid, M., & Sathyapalan, T.
Affiliations
  • Department of Academic Diabetes and Endocrinology, Allam Diabetes Centre, Hull University Teaching Hospitals NHS Trust, Hull HU3 2JZ, UK
  • Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland
  • School of Sport, Exercise and Rehabilitation Sciences, University of Hull, Hull HU6 7 RX, UK
  • School of Psychology and Social Work, University of Hull, Hull HU6 7 RX, UK
  • Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, 09121 Cagliari, Italy
  • Institute of Clinical and Applied Health Research, Hull York Medical School, Hull HU6 7 RX, UK
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2023-09-06
Volume
15
Issue
18
Pages
3872
ISSN
2072-6643
DOI
10.3390/nu15183872
Cited by
33
References
16
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • an NIHR clinical lectureship
  • Hull University Teaching Hospitals NHS

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