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Cited by 13

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Examining the Association between Coffee Intake and the Risk of Developing Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis

Lee, Jasmine, Yau, Chun, Loh, Caitlin, Lim, Wei, Teoh, Seth, Yau, Chun, Ong, Clarence, Thumboo, Julian, Namasivayam, Vikneswaran, Ng, Qin·2023·Nutrients
DOI 10.3390/nu15224745
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Abstract

Irritable bowel syndrome (IBS) is a highly prevalent disorder of brain–gut interaction with a significant impact on quality of life. Coffee is a widely consumed beverage with numerous bioactive compounds that have potential effects on human health and disease states. Current studies on the effect of regular coffee consumption on the risk of developing IBS symptoms have yielded conflicting results. This systematic review and meta-analysis aimed to determine whether coffee intake is associated with developing IBS. A systematic literature search was performed in three electronic databases, namely PubMed, EMBASE, and The Cochrane Library, from inception until 31 March 2023. All original studies reporting associations between coffee intake and IBS were considered for inclusion. Odds ratios (ORs) were calculated for each study, and estimates were pooled, and where appropriate, 95% confidence intervals (95% CI) and p-values were calculated. Eight studies comprising 432,022 patients were included in the final meta-analysis. Using a fixed-effects model, coffee drinkers (any intake) had a reduced likelihood of developing IBS compared to controls, with a pooled OR of 0.84 (95% CI: 0.80 to 0.84). Sensitivity analysis confirmed the stability of the estimates. Future research should prioritise prospective cohort studies that are robust and closely track the development of incident IBS in previously healthy individuals.

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Research works printed but not linked: 34

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Cited by

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Metadata

Authors
Lee, J., Yau, C., Loh, C., Lim, W., Teoh, S., Yau, C., Ong, C., Thumboo, J., Namasivayam, V., & Ng, Q.
Venue
Nutrients
Publisher
MDPI AG
Published
2023-11-10
Volume
15
Issue
22
Pages
4745
ISSN
2072-6643
DOI
10.3390/nu15224745
Cited by
13
References
10
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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