The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth
Abstract
Coffee is a relatively rich source of chlorogenic acids (CGA), which, as other polyphenols, have been postulated to exert preventive effects against CVD and type 2 diabetes. As a considerable proportion of ingested CGA reaches the large intestine, CGA may be capable of exerting beneficial effects in the large gut. Here, we utilise a stirred, anaerobic, pH-controlled, batch culture fermentation model of the distal region of the colon in order to investigate the impact of coffee and CGA on the growth of the human faecal microbiota. Incubation of coffee samples with the human faecal microbiota led to the rapid metabolism of CGA (4 h) and the production of dihydrocaffeic acid and dihydroferulic acid, while caffeine remained unmetabolised. The coffee with the highest levels of CGA ( P < 0·05, relative to the other coffees) induced a significant increase in the growth of Bifidobacterium spp. relative to the control vessel at 10 h after exposure ( P < 0·05). Similarly, an equivalent quantity of CGA (80·8 mg, matched with that in high-CGA coffee) induced a significant increase in the growth of Bifidobacterium spp. ( P < 0·05). CGA alone also induced a significant increase in the growth of the Clostridium coccoides – Eubacterium rectale group ( P < 0·05). This selective metabolism and subsequent amplification of specific bacterial populations could be beneficial to host health.
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“Fermentation with a concentration of chlorogenic acids equivalent to a coffee rich in chlorogenic acids produced a similar stimulation of the growth of Bifidobacteria spp. [142], reflecting that the effects of coffee on gut microbiota seem to be mainly due to its richness in polyphenols [142,143].”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [142]
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“Significant increases in the growth of Bifidobacterium spp. relative to controls were also reported after 10 h incubation of coffee samples enriched in chlorogenic acid with human fecal distal colon samples.”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [142]
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“Chlorogenic acid alone had a similar effect and also induced a significant increase in the growth of the Clostridium coccoides-Eubacterium rectale group.”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [142]
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Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
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“Further bacterial metabolism occurs here((8,9)), with most undergoing cleavage of the ester link between quinic acid and caffeic acid.”
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Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Mujagic, Z., Vila, A. V., Falony, G., Vieira-Silva, S., et al. (2016) · Science · doi:10.1126/science.aad3369 · Cited by 1,914
Parkinson’s Disease and the Gastrointestinal Microbiome
Lubomski, M., Tan, A. H., Lim, S.-Y., Holmes, A. J., Davis, R. L., & Sue, C. M. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09320-1 · Cited by 172
The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease
Yang, D., Zhao, D., Ali Shah, S. Z., Wu, W., Lai, M., Zhang, X., Li, J., Guan, Z., Zhao, H., Li, W., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01155 · Cited by 162
Linking dietary patterns with gut microbial composition and function
Sheflin, A. M., Melby, C. L., Carbonero, F., & Weir, T. L. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1270809 · Cited by 162
Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update
Nehlig, A. (2022) · Nutrients · doi:10.3390/nu14020399 · Cited by 158
Metadata
- Authors
- Mills, C. E., Tzounis, X., Oruna-Concha, M.-J., Mottram, D. S., Gibson, G. R., & Spencer, J. P. E.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-03-26
- Volume
- 113
- Issue
- 8
- Pages
- 1220-1227
- ISSN
- 0007-1145
- 1475-2662
- Cited by
- 168
- References
- 11
- Language
- en
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