Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study
Open accessAbstract
Gymnema sylvestre (GS) and berberine (BBR) are natural products that have demonstrated therapeutic potential for the management of obesity and its comorbidities, as effective and safe alternatives to synthetic drugs. Although their anti-obesogenic and antidiabetic properties have been widely studied, comparative research on their impact on the gene expression of adipokines, such as resistin (Res), omentin (Ome), visfatin (Vis) and apelin (Ap), has not been reported. Methodology: We performed a comparative study in 50 adult Mexican patients with obesity treated with GS or BBR for 3 months. The baseline and final biochemical parameters, body composition, blood pressure, gene expression of Res, Ome, Vis, and Ap, and safety parameters were evaluated. Results: BBR significantly decreased (p < 0.05) body weight, blood pressure and Vis and Ap gene expression and increased Ome, while GS decreased fasting glucose and Res gene expression (p < 0.05). A comparative analysis of the final measurements revealed a lower gene expression of Ap and Vis (p < 0.05) in patients treated with BBR than in those treated with GS. The most frequent adverse effects in both groups were gastrointestinal symptoms, which attenuated during the first month of treatment. Conclusion: In patients with obesity, BBR has a better effect on body composition, blood pressure, and the gene expression of adipokines related to metabolic risk, while GS has a better effect on fasting glucose and adipokines related to insulin resistance, with minimal side effects.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Less effective drugs for weight loss, such as sympathomimetics and lipase inhibitors, were associated with more subtle AEs including oily stools and fecal urgency.
“Less effective drugs for weight loss, such as sympathomimetics and lipase inhibitors, were associated with more subtle AEs including oily stools and fecal urgency [3,14].”
From Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review (2025) · cites this paper as [14]
Natural or complementary products such as berberine, silibnin, and Lipigo have been studied for weight loss, with reported side effects ranging from bloating and flatulence to more clinically significant GI disturbances.
“Additionally, some natural or complementary products, such as berberine, silibnin, and Lipigo, have been studied for weight loss, with reported side effects ranging from bloating and flatulence to more clinically significant GI disturbances [14,17].”
From Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review (2025) · cites this paper as [14]
Berberine caused hemorrhoidal bleeding (28%), nausea (20%), and constipation (16%); all symptoms were mild and self-limited.
“Berberine caused hemorrhoidal bleeding (28%), nausea (20%), constipation (16%); however, all symptoms were mild and self-limited [14].”
From Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review (2025) · cites this paper as [14]
In Bandala et al., Gymnema sylvestre caused loose stools (52%), dysgeusia (40%), diarrhea (28%), reflux (28%), and nausea (20%).
“In Bandala et al., Gymnema sylvestre caused loose stools (52%), dysgeusia (40%), diarrhea (28%), reflux (28%), nausea (20%).”
From Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review (2025) · cites this paper as [14]
Lipigo, Gymnema sylvestre, berberine, obex, and vutiglabridin demonstrated favorable short-term tolerability with only mild, transient GI events.
“Agents such as Lipigo, Gymnema sylvestre, berberine, obex, and vutiglabridin demonstrated favorable short-term tolerability with only mild, transient GI events [14,15,17,19].”
From Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review (2025) · cites this paper as [14]
Natural and emerging compounds such as silibinin, Lipigo, Gymnema sylvestre, berberine, and vutiglabridin appear well tolerated in early studies.
“Natural and emerging compounds such as silibinin, Lipigo, Gymnema sylvestre, berberine, and vutiglabridin appear well tolerated in early studies, but their small sample sizes and short follow-up preclude strong conclusions [14,15,17,22].”
From Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review (2025) · cites this paper as [14]
Natural and investigational products such as Gymnema sylvestre and berberine likely act through local modulation of gut microbiota and bile acid metabolism, producing mild, transient discomfort.
“Natural and investigational products such as Gymnema sylvestre and berberine likely act through local modulation of gut microbiota and bile acid metabolism, producing mild, transient discomfort [14,22].”
From Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review (2025) · cites this paper as [14]
The small sample sizes and short follow-up of studies of natural and emerging compounds preclude strong conclusions.
“Natural and emerging compounds such as silibinin, Lipigo, Gymnema sylvestre, berberine, and vutiglabridin appear well tolerated in early studies, but their small sample sizes and short follow-up preclude strong conclusions [14,15,17,22].”
From Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review (2025) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391 · see citing works
Efficacy of berberine in patients with type 2 diabetes mellitus
Yin, J., Xing, H., & Ye, J. (2008) · Metabolism · doi:10.1016/j.metabol.2008.01.013 · Cited by 801 · see citing works
Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine
Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2404 · Cited by 573 · cited 2× · see citing works
“Another study reported that glycosylated hemoglobin decreased after BBR treatment (0.5 g b.i.d.), and there were significant improvements in blood glucose and lipid levels [88].”
BackgroundInfluentialResistin: functional roles and therapeutic considerations for cardiovascular disease
Jamaluddin, M. S., Weakley, S. M., Yao, Q. C., & Chen, C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01369.x · Cited by 538 · see citing works
Anatomical, Physiological, and Functional Diversity of Adipose Tissue
Zwick, R. K., Guerrero‐Juarez, C. F., Horsley, V., & Plikus, M. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.002 · Cited by 526 · see citing works
The role of resistin as a regulator of inflammation: Implications for various human pathologies
Filková, M., Haluzík, M., Gay, S., & Šenolt, L. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.07.013 · Cited by 451 · see citing works
The complex role of adipokines in obesity, inflammation, and autoimmunity
Taylor, E. B. (2021) · Clinical Science · doi:10.1042/cs20200895 · Cited by 349 · see citing works
Shanmugasundaram, E. R. B., Rajeswari, G., Baskaran, K., Kumar, B. R. R., Shanmugasundaram, K. R., & Ahmath, B. K. (1990) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(90)90107-5 · Cited by 264 · see citing works
Recinella, L., Orlando, G., Ferrante, C., Chiavaroli, A., Brunetti, L., & Leone, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.578966 · Cited by 261 · see citing works
Phytochemical and Pharmacological Properties ofGymnema sylvestre: An Important Medicinal Plant
Tiwari, P., Mishra, B. N., & Sangwan, N. S. (2014) · BioMed Research International · doi:10.1155/2014/830285 · Cited by 242 · see citing works
Excess body weight: Novel insights into its roles in obesity comorbidities
Zhang, X., Ha, S., Lau, H. C.-H., & Yu, J. Q. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.03.008 · Cited by 242 · see citing works
Mechanism of action of natural products used in the treatment of diabetes mellitus
Prabhakar, P. K., & Doble, M. (2011) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-011-0810-3 · Cited by 240 · see citing works
Effects of berberine on glucose metabolism in vitro
Yin, J., Hu, R., Chen, M., Tang, J., Li, F., Yang, Y., & Chen, J. (2002) · Metabolism · doi:10.1053/meta.2002.34715 · Cited by 234 · see citing works
Adipokine resistin promotes in vitro angiogenesis of human endothelial cells
Mu, H. H., OHASHI, R., YAN, S., Chai, H., Yang, H., LIN, P., YAO, Q., & CHEN, C. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.015 · Cited by 209 · see citing works
Kanetkar, P., Singhal, R. S., & Kamat, M. Y. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2007010 · Cited by 191 · see citing works
Effects and mechanisms of berberine in diabetes treatment
Yin, J., Ye, J., & Jia, W. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.003 · Cited by 183 · see citing works
Preuss, H. G., Bagchi, D., Bagchi, M., Rao, C. V. S., Dey, D. K., & Satyanarayana, S. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00328.x · Cited by 182 · see citing works
Sahebkar, A. (2012) · BioFactors · doi:10.1002/biof.1062 · Cited by 171 · see citing works
Vascular effects of apelin: Mechanisms and therapeutic potential
Mughal, A., & O’Rourke, S. T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.013 · Cited by 171 · see citing works
Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre
Khan, F. I., Sarker, M. M. R., Ming, L. C., Mohamed, I. N., Zhao, C., Sheikh, B. Y., Tsong, H. F., & Rashid, M. A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01223 · Cited by 170 · see citing works
Apelin Levels Are Increased in Morbidly Obese Subjects with Type 2 Diabetes Mellitus
Soriguer, F., Garrido‐Sánchez, L., García‐Serrano, S., García‐Almeida, J. M., García-Arnés, J. A., Tinahones, F. J., & García‐Fuentes, E. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9955-y · Cited by 168 · see citing works
Heo, Y. J., Choi, S., Jeon, J. Y., Han, S. J., Kim, D. J., KANG, Y. Y., Lee, K. W., & Kim, H. J. (2019) · Journal of Diabetes Research · doi:10.1155/2019/4021623 · Cited by 160 · see citing works
The effect of Berberine on weight loss in order to prevent obesity: A systematic review
Ilyas, Z., Perna, S., Al-thawadi, S., Alalwan, T. A., Riva, A., Petrangolini, G., Gasparri, C., Infantino, V., Peroni, G., & Rondanelli, M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110137 · Cited by 143 · see citing works
Su, K., Li, Y.-R., Zhang, D., Yuan, J.-H., Zhang, C., Liu, Y., Song, L.-M., Lin, Q., Li, M.-W., & Dong, J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01399 · Cited by 140 · see citing works
Complementary and alternative medicine for the treatment of type 2 diabetes.
Nahas, R., & Moher, M. (2009) · PubMed Central · Cited by 139 · see citing works
Lipid-lowering effect of berberine in human subjects and rats
Hu, Y., Ehli, E. A., Kittelsrud, J. M., Ronan, P. J., Munger, K. A., Downey, T., Bohlen, K., Callahan, L. B., Munson, V., Jahnke, M., et al. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.05.009 · Cited by 136 · see citing works
Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway
Liu, D., Zhang, Y., Liu, Y., Hou, L.-Q., Li, S., Tian, H., & Zhao, T.-Y. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-125066 · Cited by 136 · see citing works
Romacho, T., Valencia, I., Ramos-González, M., Vallejo, S., López‐Esteban, M., Lorenzo, Ó., Cannata, P., Romero, A., Hipólito‐Luengo, Á. S., Gómez-Cerezo, J. F., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62190-w · Cited by 132 · see citing works
Berberine and Its Study as an Antidiabetic Compound
Utami, A. R., Maksum, I. P., & Deawati, Y. (2023) · Biology · doi:10.3390/biology12070973 · Cited by 110 · see citing works
Ye, Y., Liu, X., Wu, N., Han, Y., Wang, J., Yu, Y., & Chen, Q. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653887 · Cited by 109 · see citing works
The Role of Apelin–APJ System in Diabetes and Obesity
Li, C., Cheng, H., Adhikari, B. K., Wang, S., Yang, N., Liu, W., Sun, J., & Wang, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.820002 · Cited by 106 · see citing works
The Role of Adipokines in Tumor Progression and Its Association with Obesity
Kim, J., Kim, J. H., & Lee, Y. J. (2024) · Biomedicines · doi:10.3390/biomedicines12010097 · Cited by 100 · see citing works
Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions
Sun, Z., Lei, H., & Zhang, Z. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.05.006 · Cited by 89 · see citing works
Al‐Romaiyan, A., Liu, B., Asare‐Anane, H., Maity, C. R., Chatterjee, S. K., Koley, N., Biswas, T., Chatterji, A. K., Huang, G., Amiel, S. A., et al. (2010) · Phytotherapy Research · doi:10.1002/ptr.3125 · Cited by 87 · see citing works
Role of visfatin in obesity-induced insulin resistance
Abdalla, M. M. I. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i30.10840 · Cited by 86 · see citing works
Current Treatments for Patients with Genetic Obesity
Faccioli, N., Poitou, C., Clément, K., & Dubern, B. (2023) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.galenos.2023.2023-3-2 · Cited by 86 · see citing works
Aleisa, A. M., Al-Rejaie, S. S., Abuohashish, H. M., Ola, M. S., Parmar, M. Y., & Ahmed, M. M. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-49 · Cited by 75 · see citing works
Ognjanovic, S., Ku, T., & Bryant‐Greenwood, G. D. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.11.003 · Cited by 72 · see citing works
Nourbakhsh, M., Nourbakhsh, M., Gholinejad, Z., & Razzaghy‐Azar, M. (2015) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.1003594 · Cited by 65 · see citing works
Wang, J., Gao, Y., Lin, F., Han, K., & Wang, X. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108187 · Cited by 64 · see citing works
Zhang, Q., Zhu, L., Zheng, M., Fan, C.-H., Li, Y., Zhang, D., He, Y., & Yang, H. (2014) · Annales d Endocrinologie · doi:10.1016/j.ando.2014.04.013 · Cited by 61 · see citing works
Apelin/APJ system: A novel promising target for anti-aging intervention
Zhou, Q., Chen, L., Tang, M., Guo, Y. C., & Li, L. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.10.011 · Cited by 60 · see citing works
Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model
Bhandari, U., Kumar, V., Tripathi, C., & Khanna, G. (2012) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.100387 · Cited by 49 · see citing works
Di Pierro, F., Bellone, I., Rapacioli, G., & Putignano, P. (2015) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s78877 · Cited by 48 · see citing works
Devangan, S., Varghese, B., Johny, E., Gurram, S., & Adela, R. (2021) · Phytotherapy Research · doi:10.1002/ptr.7265 · Cited by 47 · see citing works
Leandro, A., Queiroz, M., Azul, L., Seiça, R. M. F., & Sena, C. M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.021 · Cited by 46 · see citing works
Sena, C. M. (2024) · Biomedicines · doi:10.3390/biomedicines12020284 · Cited by 45 · see citing works
Bo, A.-R., & Thorsson, O. (2003) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2002-021547 · Cited by 42 · see citing works
Derosa, G., Catena, G., Gaudio, G. V., D’Angelo, A., & Maffioli, P. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154947 · Cited by 42 · see citing works
Gymnema sylvestre for Diabetes: From Traditional Herb to Future’s Therapeutic
Tiwari, P., Ahmad, K., & Baig, M. H. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612823666161108162048 · Cited by 40 · see citing works
Zúñiga, L. Y., González-Ortı́z, M., & Martínez‐Abundis, E. (2017) · Journal of Medicinal Food · doi:10.1089/jmf.2017.0001 · Cited by 40 · see citing works
Novel nutraceutic therapies for the treatment of metabolic syndrome
Martínez‐Abundis, E., Villar, M. M.-D., Pérez-Rubio, K. G., Zúñiga, L. Y., Cortez-Navarrete, M., Ramírez-Rodríguez, A. M., & González-Ortı́z, M. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i7.142 · Cited by 39 · see citing works
Li, Y., Zheng, M., Xing, Z., Huang, Y., Khalid, A., Malik, A., Shah, P. A., Karim, S., Azhar, S., & Hou, X. (2015) · PubMed · Cited by 39 · see citing works
Tian, H., Kang, Y., Gao, H., Shi, X., Fu, L., Li, Y., Jia, X.-Y., Liu, K., Qi, J., Li, H., et al. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.09.206 · Cited by 39 · see citing works
Concentrations of omentin and vaspin versus insulin resistance in obese individuals
Sperling, M., Grzelak, T., Pelczyńska, M., Jasinska, P., Bogdański, P., Pupek‐Musialik, D., & Czyżewska, K. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.07.012 · Cited by 35 · see citing works
Zhou, Z., Qi, J., Lim, C. W., Kim, J.-W., & Kim, B. (2020) · Toxicology · doi:10.1016/j.tox.2020.152579 · Cited by 35 · see citing works
The impact of adipokines on vascular networks in adipose tissue
Vliora, M., Ravelli, C., Grillo, E., Corsini, M., Flouris, A. D., & Mitola, S. M. F. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.008 · Cited by 35 · see citing works
Liang, Z., Wu, Y., Xu, J., Qin, F., & Chen, D. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12385 · Cited by 34 · see citing works
Chuang, T. Y., Wu, H. L., Min, J., Diamond, M. P., Azziz, R., & Chen, Y. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0429-3 · Cited by 34 · see citing works
Asprosin, visfatin and subfatin as new biomarkers of obesity and metabolic syndrome.
Uğur, K., Erman, F., Türkoğlu, S., Aydin, Y., Aksoy, A., Lale, A., Karagöz, Z. K., Ugur, I., Akkoç, R. F., & Yalniz, M. (2022) · PubMed · doi:10.26355/eurrev_202203_28360 · Cited by 33 · see citing works
Saeidi, A., Saei, M. A., Mohammadi, B., Zarei, H. R. A., Vafaei, M., Mohammadi, A. S., Barati, M., Montazer, M., Razi, O., Kiyumi, M. H. A., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1141796 · Cited by 33 · see citing works
Jia, R., Hou, Y., Zhang, L., Li, B. J., & Zhu, J. X. (2024) · Antioxidants · doi:10.3390/antiox13050548 · Cited by 33 · see citing works
Martínez, L. A. G., Sánchez-Ruiz, L. A., Zúñiga, L. Y., González-Ortı́z, M., & Martínez‐Abundis, E. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2020.0024 · Cited by 32 · see citing works
Huang, J., Kang, S., Park, S.-J., & Im, D. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.003 · Cited by 31 · see citing works
Wan, Q., Liu, Z., Yang, Y., & Cui, X. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3440 · Cited by 31 · see citing works
Kim, H.-J., Hong, S., Chang, S.-H., Kim, S., Lee, A. Y., Jang, Y., Davaadamdin, O., Yu, K., Kim, J., & Cho, M. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2016.03.037 · Cited by 29 · see citing works
(2017) · PubMed · Cited by 29 · see citing works
Yang, H., Kim, J., Shin, D., Kim, J.-Y., You, J., Lee, H.-C., Jang, H., & Kim, H.-S. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155343 · Cited by 28 · see citing works
Sperling, M., Grzelak, T., Pelczyńska, M., Bogdański, P., Formanowicz, D., & Czyżewska, K. (2023) · Biomedicines · doi:10.3390/biomedicines11020331 · Cited by 28 · see citing works
Jangam, A., Tirunavalli, S. K., Adimoolam, B. M., Kasireddy, B., Patnaik, S. S., Erukkambattu, J., Thota, J. R., Andugulapati, S. B., & Addlagatta, A. (2023) · Inflammopharmacology · doi:10.1007/s10787-022-01133-5 · Cited by 27 · see citing works
The Role of Omentin-1 in Cancers Development and Progression
Dec, P., Poniewierska-Baran, A., Modrzejewski, A., & Pawlik, A. (2023) · Cancers · doi:10.3390/cancers15153797 · Cited by 27 · see citing works
Luo, H. L., Kashiwagi, A., Shibahara, T., & Yamada, K. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-9049-7 · Cited by 26 · see citing works
Gymnemic Acids Inhibit Sodium-Dependent Glucose Transporter 1
Wang, Y., Dawid, C., Kottra, G., Daniel, H., & Hofmann, T. F. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf501766u · Cited by 26 · see citing works
Anti-obesity Effect of Gymnema sylvestre Extract on High Fat Diet-induced Obesity in Wistar Rats
Kumar, V., Bhandari, U., Tripathi, C., & Khanna, G. (2013) · Drug Research · doi:10.1055/s-0033-1349852 · Cited by 25 · see citing works
Serum apelin levels and metabolic risk markers in obese women
Zaki, M. E., Kamal, S., Ezzat, W. M., Hassan, N. A.-M., Yousef, W., Ryad, H., Mohamed, R., Youness, E. R., Basha, W. A., & Elhosary, Y. A. (2017) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2017.05.002 · Cited by 24 · see citing works
Hetta, . F., Eldeen, M. E. E., Mohamed, G. A., Gaber, M. A., ElBadre, H. M., Ahmed, E. A., Abd-ellatief, R. B., El-Baky, R. M. A., Elkady, A., Nafee, A. M. A., et al. (2018) · PubMed · Cited by 24 · see citing works
A co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ
Wang, M., Xu, R., Liu, X., Zhang, L., Qiu, S., Lu, Y., Zhang, P., Yan, M., & Zhu, J. (2022) · Communications Biology · doi:10.1038/s42003-022-03776-0 · Cited by 23 · see citing works
Muzaffar, H., Qamar, I., Bashir, M., Jabeen, F., Irfan, S., & Anwar, H. (2023) · Metabolites · doi:10.3390/metabo13040516 · Cited by 21 · see citing works
Malekaneh, M., Dehghani, K., Mogharnasi, M., Saghebjoo, M., Sarir, H., & Nayebifar, S. (2022) · Mediators of Inflammation · doi:10.1155/2022/9539286 · Cited by 20 · see citing works
Schroeder, J. A., & Flannery-Schroeder, E. (2005) · PubMed · Cited by 18 · see citing works
Pothuraju, R., Sharma, R. K., Rather, S. A., & Singh, S. (2016) · Journal of Intercultural Ethnopharmacology · doi:10.5455/jice.20160623122710 · Cited by 18 · see citing works
Ghosh, A. R., Alsayari, A., Habib, A. H., Wahab, S., Nadig, A. P. R., Rafeeq, M. M., Binothman, N., Aljadani, M., Al-Dhuayan, I. S., ALaqeel, N. K., et al. (2023) · Antioxidants · doi:10.3390/antiox12010134 · Cited by 16 · see citing works
Vora, D., Kapadia, H., Dinesh, S., Sharma, S., & Manjegowda, D. S. (2023) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-023-00529-6 · Cited by 16 · see citing works
Berberine attenuates olanzapine induced-metabolic syndrome.
Al-Naimi, M. S., Rasheed, H. A., Al-Kuraishy, H. M., & Al-Gareeb, A. I. (2019) · PubMed · Cited by 13 · see citing works
Basciani, S., Nordio, M., Dinicola, S., Unfer, V., & Gnessi, L. (2023) · Nutrients · doi:10.3390/nu15143142 · Cited by 12 · see citing works
Congenital disorders of intestinal digestion and absorption (sugars, proteins, lipids, ions)
Peretti, N., & Mas, E. (2022) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2022.101785 · Cited by 9 · see citing works
Tu, J., Luo, X., Li, B.-T., Li, Y., & Xu, G. (2016) · China Journal of Chinese Materia Medica · doi:10.4268/cjcmm20161103 · Cited by 7 · see citing works
Serum apelin-12 and obesity-related markers in Egyptian children with Down syndrome
Yahia, S., Salem, N. A., El-Hawary, A. K., Salem, M., El-Farahaty, R. M., El‐Gilany, A., Shoaib, R. M. S., & Noureldin, M. A. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-05315-3 · Cited by 4 · see citing works
Serum visfatin levels in obese and non-obese individuals; A comparative cross-sectional study.
Younus, I., Iqbal, S., Shahid, M., & Hassan, H. (2023) · The Professional Medical Journal · doi:10.29309/tpmj/2023.30.01.7169 · Cited by 2 · see citing works
Flagged first, then by citations
3 of the 93 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Obesity: pathophysiology and therapeutic interventions
Kong, Y., Yang, H., Nie, R., Zhang, X., Zuo, F., Zhang, H., & Nian, X. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00264-9 · Cited by 89 · see citing works
Kong, Y., Yang, H., Nie, R., Zhang, X., Zhang, H., & Nian, X. (2025) · European journal of medical research · doi:10.1186/s40001-025-02738-6 · Cited by 40 · see citing works
Takrori, E., Peshin, S., & Singal, S. (2025) · Medicina · doi:10.3390/medicina61111987 · Cited by 13 · see citing works
Raqib, R., & Sarker, P. (2024) · Biomolecules · doi:10.3390/biom14121497 · Cited by 11 · see citing works
The effect of berberine on obesity indices: a systematic review and meta-analysis
Vahed, I. E., Shahir-Roudi, E., Nojumi, S., Golmohammadi, S., Shahrebabak, M. M., Moghadam, N. S. T., Bagheryan, A. S., Moftakhar, M., Shamsipour, F., Jafari, M., et al. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01943-x · Cited by 9 · see citing works
Zhang, W., Guo, S., Dou, J., Zhang, X., Shi, F., Zhang, C., Zhang, H., Lan, X., & Su, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1543697 · Cited by 7 · see citing works
Potential Health Effects of the Natural Alkaloid Berberine: A Narrative Review
Şanlıer, N., Özler, E., & Karanfil, N. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf192 · Cited by 6 · see citing works
Nrf2 in obesity: Mechanisms, models, and bioactive modulators
Shalova, I. N., Medoro, A., Davinelli, S., Bender, N., & Saso, L. (2026) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2026.06.004 · Cited by 1 · see citing works
Zhang, R., Zhang, Y., Xi, X., Du, P., Guo, C., Zhang, Y., Song, B., Xu, X., Ni, Z., Wang, Y., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1652703 · Cited by 1 · see citing works
Abdallah, H., Khalil, M., Mahdi, L., Pietragalla, G., Faienza, M. F., Garruti, G., & Portincasa, P. (2026) · Nutrients · doi:10.3390/nu18142317 · Cited by 1 · see citing works
Xie, J., Cao, J., Zhang, S., Zhang, J., Wu, G., Qiu, X., Chen, L., & Yang, G. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1935151 · Cited by 1 · see citing works
Sümer, A., Demirtaş, Ö., Pınarbaş, E., Kutlu, E. Y., & Kılıç, H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.05.616820 · Cited by 1 · see citing works
Vaishnav, K., Maurya, A., Durgapal, A., & Rana, T. S. (2025) · Journal of Applied Research on Medicinal and Aromatic Plants · doi:10.1016/j.jarmap.2025.100631
Joshi, G., Goutam, N., Vashisht, K., Shivani, S., Harmanbir, K., Kaur, T., & Joshi, N. (2026) · Scripta Medica · doi:10.5937/scriptamed57-59440
Saeed, F., Sultan, M. T., Raza, H., Noman, A. M., Haroon, N., & Jbawi, E. M. A. (2026) · JSFA reports · doi:10.1002/jsf2.70087
Chen, Y.-X., Yang, Q.-W., Zhang, L., Sun, M.-H., Tong, H.-Y., Yi-yu, D., Hu, Y., Jiang, L., Liu, J.-T., & Zhao, J. X. (2026) · Food & Function · doi:10.1039/d6fo03150a
Moyetón-Hernández, M. D. R., Bandala, C., Guadarrama-Castillo, M., Medina-Santillán, R., & Lara‐Padilla, E. (2026) · Nutrients · doi:10.3390/nu18183000
Self-citationAntioxidants as a Link Between Diabetes and Potential Plant-Based Therapies
Kuryłowicz, A., Dobrowolski, L., Słupecka‐Ziemilska, M., Kościów, Z., & Kuczeriszka, M. (2026) · Antioxidants · doi:10.3390/antiox15091206
- Authors
- Bandala, C., Carro-Rodríguez, J., Cárdenas-Rodríguez, N., Peña-Montero, I., Gómez-López, M., Hernández-Roldán, A. P., Huerta-Cruz, J. C., Muñoz-González, F., Ignacio-Mejía, I., Domínguez, B., & Lara-Padilla, E.
- Affiliations
- Instituto Politécnico Nacional (MX)
- Laboratorio de Neurociencias, Instituto Nacional de Pediatría, Mexico City 04530, Mexico
- Laboratorio de Obesidad, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico
- Unidad de Investigación en Farmacología, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Secretaria de Salud, Mexico City 14080, Mexico
- Laboratorio de Medicina Traslacional, Escuela Militar de Graduados en Sanidad, Universidad del Ejército y Fuerza Aérea, Mexico City 11200, Mexico
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2024-07-16
- Volume
- 16
- Issue
- 14
- Pages
- 2284
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC11280467
- OpenAlex
- W4400683279
- Cited by
- 18
- References
- 93
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 2
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Instituto Politecnico Nacional (2170253, 221826)
- Consejo Nacional de Ciencia y Tecnología (2170253, 221826)
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- Gymnema sylvestre, berberine, obesity, adipokines, resistin, omentin, visfatin, apelin, body composition, blood pressure, fasting blood glucose, insulin resistance, gene expression, herbal medicine, antidiabetic drugs, adverse effects
- MeSH terms
- Apelin, Adult, Berberine, Blood Glucose, Blood Pressure, Body Composition, Female, Humans, Male, Middle Aged, Obesity, Plant Extracts, Cytokines, Anti-Obesity Agents, Gymnema sylvestre, Lectins, Resistin, Adipokines, Nicotinamide Phosphoribosyltransferase, GPI-Linked Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
