Effect of Supplementation with a Specific Probiotic (Bifidobacterium bifidum PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial
Open accessAbstract
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the appearance of recurrent eczematous lesions and intense itching. The World Allergy Organization (WAO) suggested the administration of probiotics in pregnant women at high risk of allergies in their children. Objectives: Our study aims to evaluate the role of administering the Bifidobacterium bifidum strain PRL2010 during pregnancy and breastfeeding in preventing and/or reducing the severity of AD manifestations in children. Methods: It is a monocentric, randomized, double-blind, placebo-controlled trial with probiotic/placebo administration since the 36th week of gestation to mothers with atopy or a family history of atopy; the effects were evaluated over the first 12 months of the children’s lives. Results: No severe adverse effects due to probiotic intake were reported in our cohort. Although proportionally fewer children with AD were in the probiotic group, the statistical analysis showed no significant differences between the probiotic and placebo groups. However, infants who developed the most severe forms of AD in the probiotic group showed a better clinical course during follow-up compared to those in the placebo group. Conclusions: In conclusion, administering the probiotic Bifidobacterium bifidum strain PRL2010 during pregnancy and breastfeeding is safe and potentially beneficial; further large-scale studies may confirm its usefulness in improving the clinical manifestation of AD in children with a family history of atopy.
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B. bifidum is a relevant member of the human gut microbiota from early life, where it plays a pivotal role in maintaining host homeostasis by modulating immune responses, inhibiting pathogenic organisms, and supporting the structural integrity of the intestinal barrier.
“This species is a relevant member of the human gut microbiota from early life, where it plays a pivotal role in maintaining host homeostasis by modulating immune responses, inhibiting pathogenic organisms, and supporting the structural integrity of the intestinal barrier [2-5] .”
From Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum (2026) · cites this paper as [5]
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- Authors
- Anania, C., Matys, V., Marra, S., De Canditiis, D., Olivero, F., Carraro, C., Giugliano, A., Zicari, A. M., & Piccioni, M. G.
- Affiliations
- Sapienza University of Rome (IT)
- Institute for the Application of Calculus (IAC)—CNR, 00185 Rome, Italy
- Independent Researcher, 00100 Rome, Italy
- Corresponding author
- Anania, Caterina
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2025-02-13
- Volume
- 17
- Issue
- 4
- Pages
- 673
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC11858544
- OpenAlex
- W4407517100
- Cited by
- 9
- References
- 25
- Citations by year
- 2026: 8 · 2025: 1
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- atopic dermatitis, probiotics, pregnancy, breastfeeding, infant allergy prevention, maternal probiotic supplementation, probiotic safety
- MeSH terms
- Bifidobacterium bifidum, Adult, Breast Feeding, Dermatitis, Atopic, Double-Blind Method, Female, Humans, Infant, Male, Pilot Projects, Pregnancy, Dietary Supplements, Probiotics
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