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Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis
Open accessAbstract
The potential associations between dietary consumption of nitrates, nitrites, and nitrosamines and gastric cancer risk have been investigated by several studies, but yielded inconclusive results. We conducted a meta-analysis to provide a quantitative assessment of their relationships. Relevant articles were identified by a systematic literature searching of PubMed and Embase databases prior to August 2015. Random-effects models were employed to pool the relative risks. A total of 22 articles consisting of 49 studies—19 studies for nitrates, 19 studies for nitrites, and 11 studies for N-nitrosodimethylamine (NDMA)—were included. The summary relative risk of stomach cancer for the highest categories, compared with the lowest, was 0.80 (95% confidence interval (CI), 0.69–0.93) for dietary nitrates intake, 1.31 (95% CI, 1.13–1.52) for nitrites, and 1.34 (95% CI, 1.02–1.76) for NDMA (p for heterogeneity was 0.015, 0.013 and <0.001, respectively). The study type was found as the main source of heterogeneity for nitrates and nitrites. The heterogeneity for NDMA could not be eliminated completely through stratified analysis. Although significant associations were all observed in case-control studies, the cohort studies still showed a slight trend. The dose-response analysis indicated similar results as well. High nitrates intake was associated with a weak but statistically significant reduced risk of gastric cancer. Whereas increased consumption of nitrites and NDMA seemed to be risk factors for cancer. Due to the lack of uniformity for exposure assessment across studies, further prospective researches are warranted to verify these findings.
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Cites
Stang, A. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9491-z · Cited by 17,396
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
QUANTITATIVE METHODS IN THE REVIEW OF EPIDEMIOLOGIC LITERATURE1
GREENLAND, S. (1987) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036298 · Cited by 1,644 · cited 1×
“Because the absolute risk of gastric cancer was low, OR and HR approximated the RR [12].”
BackgroundIngested nitrate and nitrite and stomach cancer risk: An updated review
Bryan, N. S., Alexander, D. D., Coughlin, J. R., Milkowski, A. L., & Boffetta, P. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.07.062 · Cited by 335
Bradbury, K. E., Appleby, P. N., & Key, T. J. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.071357 · Cited by 328
Galanis, D. (1998) · International Journal of Epidemiology · doi:10.1093/ije/27.2.173 · Cited by 181
NO-Rich Diet for Lifestyle-Related Diseases
Kobayashi, J., Ohtake, K., & Uchida, H. (2015) · Nutrients · doi:10.3390/nu7064911 · Cited by 94
Ward, M. H., Heineman, E. F., Markin, R. S., & Weisenburger, D. D. (2008) · International Journal of Occupational and Environmental Health · doi:10.1179/oeh.2008.14.3.193 · Cited by 74 · cited 1×
“Ward, 2008 [33], USA 79 (ě21 years/histologically confirmed) 321 populationbased 1988–1994 short Health Habits and History Questionnaire Nitrates mg/day derived from vegetables, processed meats, and water/based on previous published literature <16.”
Background
Cited by
Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention
Thrift, A. P., Wenker, T. N., & El-Serag, H. B. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00747-0 · Cited by 828
Ajani, J. A., Lee, J., Sano, T., Janjigian, Y. Y., Fan, D., & Song, S. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.36 · Cited by 594
Nitrates/Nitrites in Food—Risk for Nitrosative Stress and Benefits
Karwowska, M., & Kononiuk, A. (2020) · Antioxidants · doi:10.3390/antiox9030241 · Cited by 360
Nitrate and Nitrite in Health and Disease
Ma, L., Hu, L., Feng, X., & Wang, S. (2018) · Aging and disease · doi:10.14336/ad.2017.1207 · Cited by 294
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186
Alisson-Silva, F., Kawanishi, K., & Varki, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.07.002 · Cited by 156
Role of Oral and Gut Microbiota in Dietary Nitrate Metabolism and Its Impact on Sports Performance
González-Soltero, R., Bailén, M., de Lucas, B., Ramírez-Goercke, M. I., Pareja-Galeano, H., & Larrosa, M. (2020) · Nutrients · doi:10.3390/nu12123611 · Cited by 54
Dietary Nitrate from Plant Foods: A Conditionally Essential Nutrient for Cardiovascular Health
Pinaffi-Langley, A. C. D. C., Dajani, R. M., Prater, M. C., Nguyen, H. V. M., Vrancken, K., Hays, F. A., & Hord, N. G. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2023.100158 · Cited by 30
Effect on health from consumption of meat and meat products
Lee, D. Y., Lee, S. Y., Jo, C., Yoon, Y., Jeong, J. Y., & Hur, S. J. (2021) · Journal of Animal Science and Technology · doi:10.5187/jast.2021.e101 · Cited by 20
Supplementation with l-arginine and nitrates vs age and individual physiological reactivity
Kurhaluk, N. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuad131 · Cited by 12
Long, B., Jiang, C., Liu, Z., Wan, P., & Guo, Q. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00973-6 · Cited by 4
Metadata
- Authors
- Song, P., Wu, L., & Guan, W.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2015-12-01
- Volume
- 7
- Issue
- 12
- Pages
- 9872-9895
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2182096672
- Cited by
- 353
- References
- 8
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- gold
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