The DOI matches its Crossref record; 434 of the 446 references it cites were found in a registry or an index, and 1 are not checked yet.
Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature
Open accessAbstract
Soyfoods have long been recognized as sources of high-quality protein and healthful fat, but over the past 25 years these foods have been rigorously investigated for their role in chronic disease prevention and treatment. There is evidence, for example, that they reduce risk of coronary heart disease and breast and prostate cancer. In addition, soy alleviates hot flashes and may favorably affect renal function, alleviate depressive symptoms and improve skin health. Much of the focus on soyfoods is because they are uniquely-rich sources of isoflavones. Isoflavones are classified as both phytoestrogens and selective estrogen receptor modulators. Despite the many proposed benefits, the presence of isoflavones has led to concerns that soy may exert untoward effects in some individuals. However, these concerns are based primarily on animal studies, whereas the human research supports the safety and benefits of soyfoods. In support of safety is the recent conclusion of the European Food Safety Authority that isoflavones do not adversely affect the breast, thyroid or uterus of postmenopausal women. This review covers each of the major research areas involving soy focusing primarily on the clinical and epidemiologic research. Background information on Asian soy intake, isoflavones, and nutrient content is also provided.
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“Messina [130] concluded that soy foods do not increase the risk of breast cancer and will not worsen cancer outcomes in women with breast cancer.”
From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [130]
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Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function
Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M., & Allgeier, C. (2020) · Nutrients · doi:10.3390/nu12123704 · Cited by 594
Soybean Bioactive Peptides and Their Functional Properties
Chatterjee, C., Gleddie, S. C., & Xiao, C.-W. (2018) · Nutrients · doi:10.3390/nu10091211 · Cited by 540
Soy, Soy Foods and Their Role in Vegetarian Diets
Rizzo, G., & Baroni, L. (2018) · Nutrients · doi:10.3390/nu10010043 · Cited by 536
Oxidative Stress: The Role of Antioxidant Phytochemicals in the Prevention and Treatment of Diseases
Muscolo, A., Oliva, M., Giulio, T., & Russo, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063264 · Cited by 502
Mayo, B., Vázquez, L., & Flórez, A. B. (2019) · Nutrients · doi:10.3390/nu11092231 · Cited by 416
Metadata
- Authors
- Messina, M.
- Affiliations
- Nutrition Matters, Inc., 26 Spadina Parkway, Pittsfield, MA 01201, USA
- Corresponding author
- Messina, Mark
- ORCID
- Messina, Mark
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2016-11-24
- Volume
- 8
- Issue
- 12
- Pages
- 754
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5188409
- OpenAlex
- W2553807112
- Cited by
- 537
- References
- 446
- Citations by year
- 2026: 63 · 2025: 86 · 2024: 58 · 2023: 53 · 2022: 61 · 2021: 57 · 2020: 68 · 2019: 37 · 2018: 30 · 2017: 21
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Soybean genetics and cultivation
- Keywords
- isoflavones, phytoestrogens, selective estrogen receptor modulators, chronic disease prevention, coronary artery disease, breast cancer, prostate cancer, hot flashes, menopausal symptoms, renal function, depressive symptoms, skin health, postmenopausal women, nutrient content
- MeSH terms
- Breast Neoplasms, Female, Heart Diseases, Humans, Legislation, Food, Male, Prostatic Neoplasms, Soy Foods
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