Cited by 561Phytoestrogen effects and researchNutritional Studies and DietSoybean genetics and cultivation

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Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature

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Messina, Mark·2016·Nutrients

DOI 10.3390/nu8120754PMC PMC5188409

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Abstract

Soyfoods have long been recognized as sources of high-quality protein and healthful fat, but over the past 25 years these foods have been rigorously investigated for their role in chronic disease prevention and treatment. There is evidence, for example, that they reduce risk of coronary heart disease and breast and prostate cancer. In addition, soy alleviates hot flashes and may favorably affect renal function, alleviate depressive symptoms and improve skin health. Much of the focus on soyfoods is because they are uniquely-rich sources of isoflavones. Isoflavones are classified as both phytoestrogens and selective estrogen receptor modulators. Despite the many proposed benefits, the presence of isoflavones has led to concerns that soy may exert untoward effects in some individuals. However, these concerns are based primarily on animal studies, whereas the human research supports the safety and benefits of soyfoods. In support of safety is the recent conclusion of the European Food Safety Authority that isoflavones do not adversely affect the breast, thyroid or uterus of postmenopausal women. This review covers each of the major research areas involving soy focusing primarily on the clinical and epidemiologic research. Background information on Asian soy intake, isoflavones, and nutrient content is also provided.

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See all 561

Authors: Messina, M.
Affiliations: Nutrition Matters, Inc., 26 Spadina Parkway, Pittsfield, MA 01201, USA
Corresponding author: Messina, Mark
ORCID: Messina, Mark
Venue: Nutrients
Publisher: MDPI AG
Published: 2016-11-24
Volume: 8
Issue: 12
Pages: 754
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu8120754
PMC: PMC5188409
OpenAlex: W2553807112
Cited by: 537
References: 446
Citations by year: 2026: 63 · 2025: 86 · 2024: 58 · 2023: 53 · 2022: 61 · 2021: 57 · 2020: 68 · 2019: 37 · 2018: 30 · 2017: 21
FWCI: 4.61
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Life Sciences › Agricultural and Biological Sciences › Plant Science › Soybean genetics and cultivation
Keywords: isoflavones, phytoestrogens, selective estrogen receptor modulators, chronic disease prevention, coronary artery disease, breast cancer, prostate cancer, hot flashes, menopausal symptoms, renal function, depressive symptoms, skin health, postmenopausal women, nutrient content
MeSH terms: Breast Neoplasms, Female, Heart Diseases, Humans, Legislation, Food, Male, Prostatic Neoplasms, Soy Foods

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Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature

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