Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview
Open accessAbstract
Prunus armeniaca L. (Rosaceae)-syn. Amygdalus armeniaca (L.) Dumort., Armeniaca armeniaca (L.) Huth, Armeniaca vulgaris Lam is commonly known as the apricot tree. The plant is thought to originate from the northern, north-western, and north-eastern provinces of China, although some data show that it may also come from Korea or Japan. The apricot fruit is used medicinally to treat a variety of ailments, including use as an antipyretic, antiseptic, anti-inflammatory, emetic, and ophthalmic remedy. The Chinese and Korean pharmacopeias describe the apricot seed as an herbal medicinal product. Various parts of the apricot plant are used worldwide for their anticancer properties, either as a primary remedy in traditional medicine or as a complementary or alternative medicine. The purpose of this review was to provide comprehensive and up-to-date information on ethnobotanical data, bioactive phytochemicals, anticancer potential, pharmacological applications, and toxicology of the genus Prunus armeniaca, thus providing new perspectives on future research directions. Included data were obtained from online databases such as PubMed/Medline, Google Scholar, Science direct, and Wiley Online Library. Multiple anticancer mechanisms have been identified in in vitro and in vivo studies, the most important mechanisms being apoptosis, antiproliferation, and cytotoxicity. The anticancer properties are probably mediated by the contained bioactive compounds, which can activate various anticancer mechanisms and signaling pathways such as tumor suppressor proteins that reduce the proliferation of tumor cells. Other pharmacological properties resulting from the analysis of experimental studies include neuroprotective, cardioprotective, antioxidant, immunostimulatory, antihyperlipidemic, antibacterial, and antifungal effects. In addition, data were provided on the toxicity of amygdalin, a compound found in apricot kernel seeds, which limits the long-term use of complementary/alternative products derived from P. armeniaca. This updated review showed that bioactive compounds derived from P. armeniaca are promising compounds for future research due to their important pharmacological properties, especially anticancer. A detailed analysis of the chemical structure of these compounds and their cytotoxicity should be carried out in future research. In addition, translational pharmacological studies are required for the correct determination of pharmacologically active doses in humans.
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It has been proposed that most bioactive molecules act as direct antioxidants and do not depend on endogenous intracellular enzymes to exert their primary action by directly reacting with free radicals.
“It has been proposed that most bioactive molecules act as direct antioxidants and they do not have a dependence on endogenous intracellular enzymes to exert their primary action by directly reacting with free radicals [69,121].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [69]
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Flagged first, then by citations
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Cited by
Sorted by citations
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
“It has been proposed that most bioactive molecules act as direct antioxidants and they do not have a dependence on endogenous intracellular enzymes to exert their primary action by directly reacting with free radicals [69,121].”
BackgroundSelf-citationNoureen, S., Noreen, S., Ghumman, S. A., Al-Hussain, S. A., Hameed, H., Anwar-Ul-Haq, M., Irfan, A., Batool, F., Hassan, M. U., Aslam, S., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-37847-x · Cited by 7 · see citing works
- Authors
- Kitic, D., Miladinovic, B., Randjelovic, M., Szopa, A., Sharifi-Rad, J., Calina, D., & Seidel, V.
- Affiliations
- Department of Pharmacy, Faculty of Medicine, University of Niš, Ave. Zorana Djindjica 81, 18000 Nis, Serbia
- Jagiellonian University (PL)
- Facultad de Medicina, Universidad del Azuay, Cuenca 14-008, Ecuador
- Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G1 1XQ, UK
- ORCID
- Venue
- Plants
- Publisher
- MDPI AG
- Published
- 2022-07-20
- Volume
- 11
- Issue
- 14
- Pages
- 1885
- ISSN
- 2223-7747 (ISSN-L)
- PMC
- PMC9325146
- OpenAlex
- W4286434256
- Cited by
- 96
- References
- 149
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 31 · 2023: 23 · 2022: 10
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Plants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Strathprints: The University of Strathclyde institutional repository (University of Strathclyde) (acceptedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- apricot, amygdalin, anticancer activity, phytochemicals, apoptosis, anti-proliferation, cytotoxicity, neuroprotection, cardioprotection, antioxidant activity, immunostimulatory effects, hypolipidemic effect, antibacterial and antifungal activity, toxicity, ethnobotany, traditional medicine, complementary and alternative medicine
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