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Design and Fabrication of Nanofibrous Dura Mater with Antifibrosis and Neuroprotection Effects on SH-SY5Y Cells

Zhao, Zhiyuan, Wu, Tong, Cui, Yu, Zhao, Rui, Wan, Qi, Xu, Rui·2022·Polymers
DOI 10.3390/polym14091882
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Abstract

The development and treatment of some diseases, such as large-area cerebral infarction, cerebral hemorrhage, brain tumor, and craniocerebral trauma, which may involve the injury of the dura mater, elicit the need to repair this membrane by dural grafts. However, common dural grafts tend to result in dural adhesions and scar tissue and have no further neuroprotective effects. In order to reduce or avoid the complications of dural repair, we used PLGA, tetramethylpyrazine, and chitosan as raw materials to prepare a nanofibrous dura mater (NDM) with excellent biocompatibility and adequate mechanical characteristics, which can play a neuroprotective role and have an antifibrotic effect. We fabricated PLGA NDM by electrospinning, and then chitosan was grafted on the nanofibrous dura mater by the EDC-NHS cross-linking method to obtain PLGA/CS NDM. Then, we also prepared PLGA/TMP/CS NDM by coaxial electrospinning. Our study shows that the PLGA/TMP/CS NDM can inhibit the excessive proliferation of fibroblasts, as well as provide a sustained protective effect on the SH-SY5Y cells treated with oxygen–glucose deprivation/reperfusion (OGD/R). In conclusion, our study may provide a new alternative to dural grafts in undesirable cases of dural injuries.

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Cited by

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Metadata

Authors
Zhao, Z., Wu, T., Cui, Y., Zhao, R., Wan, Q., & Xu, R.
Affiliations
  • Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao 266000, China
  • Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, China
ORCID
Venue
Polymers
Publisher
MDPI AG
Published
2022-05-05
Volume
14
Issue
9
Pages
1882
ISSN
2073-4360
DOI
10.3390/polym14091882
Cited by
12
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Natural Science Foundation of Shandong Province (ZR202102190696, 82001970, 32171322, 31900634, 82071385, ZR2021YQ17, YESS20200097, 2019YFC0120000, 2018YFC1312300, 2019JZZY021010)
  • Affiliated Hospital of Qingdao University (ZR202102190696, 82001970, 32171322, 31900634, 82071385, ZR2021YQ17, YESS20200097, 2019YFC0120000, 2018YFC1312300, 2019JZZY021010)
  • National Natural Science Foundation of China (ZR202102190696, 82001970, 32171322, 31900634, 82071385, ZR2021YQ17, YESS20200097, 2019YFC0120000, 2018YFC1312300, 2019JZZY021010)
  • Natural Science Foundation of Shandong Province, China (ZR202102190696, 82001970, 32171322, 31900634, 82071385, ZR2021YQ17, YESS20200097, 2019YFC0120000, 2018YFC1312300, 2019JZZY021010)
  • Young Elite Scientists Sponsorship Program by CAST (ZR202102190696, 82001970, 32171322, 31900634, 82071385, ZR2021YQ17, YESS20200097, 2019YFC0120000, 2018YFC1312300, 2019JZZY021010)
  • National Key R&D Program of China (ZR202102190696, 82001970, 32171322, 31900634, 82071385, ZR2021YQ17, YESS20200097, 2019YFC0120000, 2018YFC1312300, 2019JZZY021010)
  • Key Research and Development Project of Shandong (ZR202102190696, 82001970, 32171322, 31900634, 82071385, ZR2021YQ17, YESS20200097, 2019YFC0120000, 2018YFC1312300, 2019JZZY021010)

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CoChat. (2026). Citation check: Design and Fabrication of Nanofibrous Dura Mater with Antifibrosis and Neuroprotection Effects on SH-SY5Y Cells. https://app.cochat.ai/papers/10.3390/polym14091882
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Zhao, Z., Wu, T., Cui, Y., Zhao, R., Wan, Q., & Xu, R. (2022). Design and Fabrication of Nanofibrous Dura Mater with Antifibrosis and Neuroprotection Effects on SH-SY5Y Cells. Polymers. https://doi.org/10.3390/polym14091882

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