Cited by 491Electrochemical sensors and biosensorsSpectroscopy Techniques in Biomedical and Chemical ResearchNon-Invasive Vital Sign Monitoring

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Non-Invasive Blood Glucose Monitoring Technology: A Review

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Tang, Liu, Chang, Shwu Jen, Chen, Ching-Jung, Liu, Jen-Tsai·2020·Sensors

DOI 10.3390/s20236925PMC PMC7731259

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Abstract

In recent years, with the rise of global diabetes, a growing number of subjects are suffering from pain and infections caused by the invasive nature of mainstream commercial glucose meters. Non-invasive blood glucose monitoring technology has become an international research topic and a new method which could bring relief to a vast number of patients. This paper reviews the research progress and major challenges of non-invasive blood glucose detection technology in recent years, and divides it into three categories: optics, microwave and electrochemistry, based on the detection principle. The technology covers medical, materials, optics, electromagnetic wave, chemistry, biology, computational science and other related fields. The advantages and limitations of non-invasive and invasive technologies as well as electrochemistry and optics in non-invasives are compared horizontally in this paper. In addition, the current research achievements and limitations of non-invasive electrochemical glucose sensing systems in continuous monitoring, point-of-care and clinical settings are highlighted, so as to discuss the development tendency in future research. With the rapid development of wearable technology and transdermal biosensors, non-invasive blood glucose monitoring will become more efficient, affordable, robust, and more competitive on the market.

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Authors: Tang, L., Chang, S. J., Chen, C.-J., & Liu, J.-T.
Affiliations: Research Center for Materials Science and Opti-Electronic Technology, College of Materials Science and Opti-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China
I-Shou University (TW)
University of Chinese Academy of Sciences (CN)
Corresponding author: Chen, Ching-Jung
Liu, Jen-Tsai
ORCID: Tang, Liu
Chang, Shwu Jen
Chen, Ching-Jung
Liu, Jen-Tsai
Venue: Sensors
Publisher: MDPI AG
Published: 2020-12-04
Volume: 20
Issue: 23
Pages: 6925
ISSN: 1424-8220 (ISSN-L)
DOI: 10.3390/s20236925
PMC: PMC7731259
OpenAlex: W3106856419
Cited by: 481
References: 149
Citations by year: 2026: 66 · 2025: 100 · 2024: 101 · 2023: 111 · 2022: 71 · 2021: 32
FWCI: 2.65
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Sensors (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Chinese Academy of Sciences
University of Chinese Academy of Sciences
Topics: Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
Keywords: non-invasive glucose monitoring, diabetes mellitus, optical glucose sensing, electrochemical glucose sensor, continuous glucose monitoring, point-of-care testing, wearable sensors
MeSH terms: Wearable Electronic Devices, Blood Glucose, Humans, Monitoring, Physiologic, Blood Glucose Self-Monitoring, Biosensing Techniques

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