The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Insect Antimicrobial Peptides, a Mini Review
Open accessAbstract
Antimicrobial peptides (AMPs) are crucial effectors of the innate immune system. They provide the first line of defense against a variety of pathogens. AMPs display synergistic effects with conventional antibiotics, and thus present the potential for combined therapies. Insects are extremely resistant to bacterial infections. Insect AMPs are cationic and comprise less than 100 amino acids. These insect peptides exhibit an antimicrobial effect by disrupting the microbial membrane and do not easily allow microbes to develop drug resistance. Currently, membrane mechanisms underlying the antimicrobial effects of AMPs are proposed by different modes: the barrel-stave mode, toroidal-pore, carpet, and disordered toroidal-pore are the typical modes. Positive charge quantity, hydrophobic property and the secondary structure of the peptide are important for the antibacterial activity of AMPs. At present, several structural families of AMPs from insects are known (defensins, cecropins, drosocins, attacins, diptericins, ponericins, metchnikowins, and melittin), but new AMPs are frequently discovered. We reviewed the biological effects of the major insect AMPs. This review will provide further information that facilitates the study of insect AMPs and shed some light on novel microbicides.
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Cites
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
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Sequence and specificity of two antibacterial proteins involved in insect immunity
Steiner, H., Hultmark, D., Engström, Å., Bennich, H., & Boman, H. G. (1981) · Nature · doi:10.1038/292246a0 · Cited by 1,427
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Bulet, P., Hetru, C., Dimarcq, J.-L., & Hoffmann, D. (1999) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(99)00015-4 · Cited by 1,041
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The relationship between peptide structure and antibacterial activity
Powers, J.-P. S., & Hancock, R. E. W. (2003) · Peptides · doi:10.1016/j.peptides.2003.08.023 · Cited by 948
Antimicrobial Peptides: Mechanisms of Action and Resistance
Bechinger, B., & Gorr, S.-U. (2017) · Journal of Dental Research · doi:10.1177/0022034516679973 · Cited by 739
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Insect antimicrobial peptides and their applications
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Cited by
Antimicrobial peptides for combating drug-resistant bacterial infections
Xuan, J., Feng, W., Wang, J., Wang, R., Zhang, B., Bo, L., Chen, Z.-S., Yang, H., & Sun, L. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100954 · Cited by 665
Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance
Manniello, M. D., Moretta, A., Salvia, R., Scieuzo, C., Lucchetti, D., Vogel, H., Sgambato, A., & Falabella, P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03784-z · Cited by 259
Metadata
- Authors
- Wu, Q., Patočka, J., & Kuča, K.
- Venue
- Toxins
- Publisher
- MDPI AG
- Published
- 2018-11-08
- Volume
- 10
- Issue
- 11
- Pages
- 461
- ISSN
- 2072-6651 (ISSN-L)
- OpenAlex
- W2899890541
- Cited by
- 481
- References
- 99
- FWCI
- 28.51
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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