The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2
Open accessAbstract
The outbreak of a novel coronavirus, which was later formally named the severe acute respiratory coronavirus 2 (SARS-CoV-2), has caused a worldwide public health crisis. Previous studies showed that SARS-CoV-2 is highly homologous to SARS-CoV and infects humans through the binding of the spike protein to ACE2. Here, we have systematically studied the molecular mechanisms of human infection with SARS-CoV-2 and SARS-CoV by protein-protein docking and MD simulations. It was found that SARS-CoV-2 binds ACE2 with a higher affinity than SARS-CoV, which may partly explain that SARS-CoV-2 is much more infectious than SARS-CoV. In addition, the spike protein of SARS-CoV-2 has a significantly lower free energy than that of SARS-CoV, suggesting that SARS-CoV-2 is more stable and may survive a higher temperature than SARS-CoV. This provides insights into the evolution of SARS-CoV-2 because SARS-like coronaviruses have originated in bats. Our computation also suggested that the RBD-ACE2 binding for SARS-CoV-2 is much more temperature-sensitive than that for SARS-CoV. Thus, it is expected that SARS-CoV-2 would decrease its infection ability much faster than SARS-CoV when the temperature rises. These findings would be beneficial for the disease prevention and drug/vaccine development of SARS-CoV-2.
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Cites
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Cited by
COVID-19: Transmission, prevention, and potential therapeutic opportunities
Lotfi, M., Hamblin, M. R., & Rezaei, N. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.05.044 · Cited by 1,016
Saliva: potential diagnostic value and transmission of 2019-nCoV
Xu, R., Cui, B., Duan, X., Zhang, P., Zhou, X., & Yuan, Q. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0080-z · Cited by 394
A Guide to COVID‐19: a global pandemic caused by the novel coronavirus SARS‐CoV‐2
Atzrodt, C. L., Maknojia, I., McCarthy, R. D. P., Oldfield, T. M., Po, J., Ta, K. T. L., Stepp, H. E., & Clements, T. P. (2020) · The FEBS Journal · doi:10.1111/febs.15375 · Cited by 341
Overview of lethal human coronaviruses
Chen, B., Tian, E.-K., He, B., Tian, L., Han, R., Wang, S., Xiang, Q., Zhang, S., El Arnaout, T., & Cheng, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0190-2 · Cited by 300
Srinivasan, S., Cui, H., Gao, Z., Liu, M., Lu, S., Mkandawire, W., Narykov, O., Sun, M., & Korkin, D. (2020) · Viruses · doi:10.3390/v12040360 · Cited by 257
Metadata
- Authors
- He, J., Tao, H., Yan, Y., Huang, S.-Y., & Xiao, Y.
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2020-04-10
- Volume
- 12
- Issue
- 4
- Pages
- 428
- ISSN
- 1999-4915 (ISSN-L)
- OpenAlex
- W3016186753
- Cited by
- 187
- References
- 11
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- gold
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