The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Herpes Virus Fusion and Entry: A Story with Many Characters
Open accessAbstract
Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often employ accessory proteins to bind receptors and/or bind the heterodimer gH/gL or even to determine cell tropism. Sorting out how these proteins function has been resolved to a large extent by structural biology coupled with supporting biochemical and biologic evidence. Together with the G protein of vesicular stomatitis virus, gB is a charter member of the Class III fusion proteins. Unlike VSV G, gB only functions when partnered with gH/gL. However, gH/gL does not resemble any known viral fusion protein and there is evidence that its function is to upregulate the fusogenic activity of gB. In the case of herpes simplex virus, gH/gL itself is upregulated into an active state by the conformational change that occurs when gD, the receptor binding protein, binds one of its receptors. In this review we focus primarily on prototypes of the three subfamilies of herpesviruses. We will present our model for how herpes simplex virus (HSV) regulates fusion in series of highly regulated steps. Our model highlights what is known and also provides a framework to address mechanistic questions about fusion by HSV and herpesviruses in general.
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Cites
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Cited by
van Riel, D., Verdijk, R., & Kuiken, T. (2015) · The Journal of Pathology · doi:10.1002/path.4461 · Cited by 394
Bourgade, K., Garneau, H., Giroux, G., Le Page, A. Y., Bocti, C., Dupuis, G., Frost, E. H., & Fülöp, T. (2015) · Biogerontology · doi:10.1007/s10522-014-9538-8 · Cited by 208
Autophagy in the eye: implications for ocular cell health.
Frost, L. S., Mitchell, C. H., & Boesze-Battaglia, K. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.04.010 · Cited by 134
Cell-fusion events induced by α-herpesviruses
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Metadata
- Authors
- Eisenberg, R. J., Atanasiu, D., Cairns, T. M., Gallagher, J. R., Krummenacher, C., & Cohen, G. H.
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2012-05-10
- Volume
- 4
- Issue
- 5
- Pages
- 800-832
- ISSN
- 1999-4915 (ISSN-L)
- OpenAlex
- W2031152855
- Cited by
- 321
- References
- 163
- FWCI
- 19.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- Eisenberg, R. J., Atanasiu, D., Cairns, T. M., Gallagher, J. R., Krummenacher, C., & Cohen, G. H. (2012). Herpes Virus Fusion and Entry: A Story with Many Characters. Viruses. https://doi.org/10.3390/v4050800
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
