Human fetal liver derived stem cell transplantation as supportive modality in the management of end stage decompensated liver cirrhosis
Open accessAbstract
Liver transplantation is the only existing modality for treating decompensated liver cirrhosis. Several factors, such as nonavailability of donors, combined with operative risks, complications associated with rejection, usage of immunosuppressive agents, and cost intensiveness, make this strategy available to only a few people. With a tremendous upsurge in the mortality rate of patients with liver disorders worldwide, there is a need to search for an alternative therapeutic tool that can combat the above limitations and serve as a supportive therapy in the management of liver diseases. Cell therapy using human fetal liver-derived stem cells can provide great potential to conservatively manage end-stage liver diseases. Therefore, the present investigation aimed to study and prove the safety and efficacy of human fetal liver-derived stem cell transplantation in patients with end-stage liver cirrhosis. Twenty-five patients with liver cirrhosis of different etiologies were infused with human fetal liver-derived stem cells (EpCAM+ve) labeled with Tc-HMPAO through hepatic artery. Our high throughput analysis using flow cytometry, RT-PCR, and cellular characterization exemplifies fetal liver cells with their high proliferation rate could be the best source for rejuvenating the diseased liver. Further, no episodes related to hepatic encephalopathy recurred in any of the subjects following hepatic stem cell transplantation. There was marked clinical improvement observed in terms of all clinical and biochemical parameters. Further, there was decrease in mean MELD score (p < 0.01) observed in 6 months follow-up in all patients. Therapy using human fetal liver stem/progenitor cells offers a potentially supportive modality to organ transplantation in the management of liver diseases.
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When the proliferation of liver parenchymal cells is hampered, especially in advanced fibrosis, liver progenitor cells may become activated and differentiate into mature hepatocytes and cholangiocytes, thereby facilitating repopulation and improving liver function.
“When the proliferation of liver parenchymal cells is hampered, especially in advanced fibrosis, LPCs may become activated and differentiate into mature hepatocytes and cholangiocytes, thereby facilitating repopulation and improving liver function [20, 41].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [20]
In a clinical trial, 25 patients with MELD scores exceeding 16 who were infused with human fetal liver-derived EpCAM+ liver progenitor cells through the hepatic artery had no procedure-related complications and showed significant improvements in MELD scores and levels of serum ALB, ALP, and bilirubin at six months.
“In a clinical trial, 25 patients with MELD scores exceeding 16 were infused with human fetal liver-derived EpCAM+ LPCs through the hepatic artery [20]. The six-month follow-up period revealed no complications related to the procedure while demonstrating significant improvements in MELD scores and levels of serum ALB, alkaline phosphatase (ALP), and bilirubin.”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [20]
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- Authors
- Khan, A. A., Shaik, M. V., Parveen, N., Rajendraprasad, A., Aleem, M. A., Aejaz, M., Srinivas, G., Avinash, T., Tiwari, S. K., Kumaresan, K., Venkateswarlu, J., Pande, G., & Habibullah, C.
- Affiliations
- Deccan College of Medical Sciences (IN)
- Centre for Cellular and Molecular Biology (IN)
- Venue
- Cell Transplantation
- Publisher
- SAGE Publications
- Published
- 2010
- Volume
- 19
- Issue
- 4
- Pages
- 409-418
- ISSN
- 0963-6897 (ISSN-L)
- OpenAlex
- W2078785430
- Cited by
- 183
- References
- 35
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 14 · 2018: 13 · 2017: 11 · 2016: 15 · 2015: 12 · 2014: 20 · 2013: 17 · 2012: 18
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- cc-by-sa
- Locations
- Cell Transplantation (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- stem cell transplantation, decompensated cirrhosis, end-stage liver disease, hepatic artery infusion, hepatic encephalopathy, MELD score, cell therapy, liver regeneration, supportive therapy
- MeSH terms
- Adult, Flow Cytometry, Humans, Liver, Liver Cirrhosis, Male, Middle Aged, Severity of Illness Index, Biomarkers, Technetium Tc 99m Exametazime, Stem Cell Transplantation, Fetal Stem Cells, Cell- and Tissue-Based Therapy
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