Cited by 340Cholangiocarcinoma and Gallbladder Cancer StudiesCarcinogens and Genotoxicity AssessmentEsophageal Cancer Research and Treatment

The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.

Bile acids as endogenous etiologic agents in gastrointestinal cancer

Open access

Bernstein, Harris, Bernstein, Carol, Payne, Claire M, Dvorak, Katerina·2009·World Journal of Gastroenterology

DOI 10.3748/wjg.15.3329PMC PMC2712893

Open this paper in CoChat — free account Open PDF

Abstract

Bile acids are implicated as etiologic agents in cancer of the gastrointestinal (GI) tract, including cancer of the esophagus, stomach, small intestine, liver, biliary tract, pancreas and colon/rectum. Deleterious effects of bile acid exposure, likely related to carcinogenesis, include: induction of reactive oxygen and reactive nitrogen species; induction of DNA damage; stimulation of mutation; induction of apoptosis in the short term, and selection for apoptosis resistance in the long term. These deleterious effects have, so far, been reported most consistently in relation to esophageal and colorectal cancer, but also to some extent in relation to cancer of other organs. In addition, evidence is reviewed for an association of increased bile acid exposure with cancer risk in human populations, in specific human genetic conditions, and in animal experiments. A model for the role of bile acids in GI carcinogenesis is presented from a Darwinian perspective that offers an explanation for how the observed effects of bile acids on cells contribute to cancer development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3748/wjg.15.3329

Cites

175 of 175 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Identification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274
Epidemiology of gastric cancer
Crew, K. D., & Neugut, A. I. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i3.354 · Cited by 2,140
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636
DNA damage-induced cell death by apoptosis
Roos, W. P., & Kaina, B. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.07.007 · Cited by 1,500
Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)
Schreck, R., Albermann, K., & Baeuerle, P. A. (1992) · Free Radical Research Communications · doi:10.3109/10715769209079515 · Cited by 1,388
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
Staudinger, J. L., Goodwin, B. J., Jones, S. A., Hawkins‐Brown, D., MacKenzie, K. I., Latour, A. M., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J. F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051551698 · Cited by 1,378
Relation of Meat, Fat, and Fiber Intake to the Risk of Colon Cancer in a Prospective Study among Women
Willett, W. C., Stampfer, M. J., Colditz, G. A., ROSNER, B. A., & Speizer, F. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012133232404 · Cited by 1,239
Vitamin D Receptor As an Intestinal Bile Acid Sensor
Makishima, M., Lu, T. T., Xie, W., Whitfield, G. K., Domoto, H., Evans, R. M., Haussler, M. R., & Mangelsdorf, D. J. (2002) · Science · doi:10.1126/science.1070477 · Cited by 1,176
UPPER GASTROINTESTINAL CANCER IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS
Spigelman, A. D., Talbot, I. C., Williams, C. B., Domizio, P., & Rw, P. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90840-4 · Cited by 797

Show all 174 references

Sorted by citations

The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925
Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924
Bile acid metabolites control TH17 and Treg cell differentiation
Hang, S., Paik, D., Yao, L., Kim, E., Trinath, J., Lu, J., Ha, S., Nelson, B. N., Kelly, S. P., Wu, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1785-z · Cited by 1,457
Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer
Yachida, S., Mizutani, S., Shiroma, H., Shiba, S., Nakajima, T., Sakamoto, T., Watanabe, H., Masuda, K., Nishimoto, Y., Kubo, M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0458-7 · Cited by 1,429
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
Wong, S. H., & Yu, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0209-8 · Cited by 1,392
Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2011.109 · Cited by 1,287
Gut microbiota imbalance and colorectal cancer
Gagnière, J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.501 · Cited by 890
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752
The role of the microbiome in cancer development and therapy
Bhatt, A. P., Redinbo, M. R., & Bultman, S. J. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21398 · Cited by 653
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Fleishman, J. S., & Kumar, S. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01811-6 · Cited by 615
Reactive Oxygen Species in the Tumor Microenvironment: An Overview
Weinberg, F., Ramnath, N., & Nagrath, D. (2019) · Cancers · doi:10.3390/cancers11081191 · Cited by 502
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
Fuchs, C. D., & Trauner, M. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00566-7 · Cited by 490
Bile acids in glucose metabolism in health and disease
Shapiro, H., Kolodziejczyk, A. A., Halstuch, D., & Elinav, E. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171965 · Cited by 481
The multifaceted role of reactive oxygen species in tumorigenesis
Kirtonia, A., Sethi, G., & Garg, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03536-5 · Cited by 452
Secondary bile acids: an underrecognized cause of colon cancer
Ajouz, H., Mukherji, D., & Shamseddine, A. I. (2014) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-12-164 · Cited by 373
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
Sun, L., Suo, C., Li, S., Zhang, H., & Gao, P. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.005 · Cited by 374
Carcinogenicity of deoxycholate, a secondary bile acid
Bernstein, C., Holubec, H., Bhattacharyya, A. K., Nguyen, H., Payne, C. M., Zaitlin, B., & Bernstein, H. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0648-7 · Cited by 351
Self-citation
Soluble Dietary Fiber, One of the Most Important Nutrients for the Gut Microbiota
Guan, Z.-W., Yu, E.-Z., & Feng, Q. (2021) · Molecules · doi:10.3390/molecules26226802 · Cited by 370
Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens
Ridlon, J. M., Ikegawa, S., Alves, J. M. P., Zhou, B., Kobayashi, A., Iida, T., Mitamura, K., Tanabe, G., Serrano, M., De Guzman, A., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m038869 · Cited by 319
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions
Cong, J., Liu, P., Han, Z., Ying, W., Li, C., Yang, Y., Wang, S., Yang, J., Cao, F., Shen, J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.014 · Cited by 333
Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma
Chen, F., Dai, X., Zhou, C., Li, K.-X., Zhang, Y., Lou, X., Zhu, Y., Sun, Y., Peng, B.-X., & Cui, W. (2021) · Gut · doi:10.1136/gutjnl-2020-323476 · Cited by 295
High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis
Eaton, J. E., Silveira, M. G., Pardi, D. S., Sinakos, E., Kowdley, K. V., Luketic, V. A., Harrison, E. M., McCashland, T. M., Befeler, A. S., Harnois, D. M., et al. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.156 · Cited by 270
Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis
Xie, G., Wang, X., Huang, F., Zhao, A., Chen, W., Yan, J., Zhang, Y., Lei, S., Ge, K., Zheng, X., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30219 · Cited by 252
Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool
Brown, D. G., Rao, S., Weir, T. L., O’Malia, J., Bazan, M., Brown, R. J., & Ryan, E. P. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0151-y · Cited by 262
The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer?
Azcárate-Peril, M. A., Sikes, M. L., & Bruno-Bárcena, J. M. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00110.2011 · Cited by 260
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208
Bile acids in the colon, from healthy to cytotoxic molecules
Barrasa, J. I., Olmo, N., Lizarbe, M. A., & Turnay, J. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.12.020 · Cited by 210
Shifts in the Fecal Microbiota Associated with Adenomatous Polyps
Hale, V. L., Chen, J., Johnson, S. P., Harrington, S. C., Yab, T. C., Smyrk, T. C., Nelson, H., Boardman, L. A., Druliner, B. R., Levin, T. R., et al. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0337 · Cited by 202
Role of Bacteria in Oncogenesis
Chang, A. H., & Parsonnet, J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00012-10 · Cited by 202
Another renaissance for bile acid gastrointestinal microbiology
Ridlon, J. M., & Gaskins, H. R. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00896-2 · Cited by 205
The bile salt export pump (BSEP) in health and disease
Kubitz, R., Dröge, C., Stindt, J., Weissenberger, K., & Häussinger, D. (2012) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2012.06.006 · Cited by 190
Colorectal carcinogenesis-update and perspectives
Raskov, H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i48.18151 · Cited by 193
The solute carrier family 10 (SLC10): Beyond bile acid transport
da Silva, T. C., Polli, J. E., & Swaan, P. W. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.004 · Cited by 195
Bile acid: a potential inducer of colon cancer stem cells
Farhana, L., Nangia‐Makker, P., Arbit, E., Shango, K., Sarkar, S. H., Mahmud, H., Hadden, T. J., Yu, Y., & Majumdar, A. P. N. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0439-4 · Cited by 177
Contribution of the 7β-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon
Lee, J., Arai, H., Nakamura, Y., Fukiya, S., Wada, M., & Yokota, A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m039834 · Cited by 171
Gut Microbiota Dysbiosis Drives the Development of Colorectal Cancer
Fan, X., Jin, Y., Chen, G., Ma, X., & Zhang, L. (2020) · Digestion · doi:10.1159/000508328 · Cited by 176
Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities
Pandey, H., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Cancers · doi:10.3390/cancers15030866 · Cited by 171
Bile acids and bile acid derivatives: use in drug delivery systems and as therapeutic agents
Faustino, C. M. C., Serafim, C., Rijo, P. M., & Reis, C. P. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1178233 · Cited by 151
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
Bhat, A. A., Nisar, S., Maacha, S., Carneiro-Lobo, T., Akhtar, S., Siveen, K. S., Wani, N. A., Rizwan, A., Bagga, P., Singh, M. K., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01294-3 · Cited by 145
Role of bile acids in colon carcinogenesis
Nguyen, T. T., Ung, T. T., Kim, N. H., & Jung, Y. D. (2018) · World Journal of Clinical Cases · doi:10.12998/wjcc.v6.i13.577 · Cited by 143
Effect of different bile acids on the intestine through enterohepatic circulation based on FXR
Xiang, J., Zhang, Z., Xie, H., Zhang, C., Bai, Y., Cao, H., Che, Q., Guo, J., & Su, Z. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1949095 · Cited by 146
The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review
Penney, N. C., Kinross, J. K., Newton, R. C., & Purkayastha, S. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.115 · Cited by 146
Impact of microbial transformation of food on health — from fermented foods to fermentation in the gastro-intestinal tract
Vlieg, J. E. V. H., Veiga, P., Zhang, C., Derrien, M., & Zhao, L. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.12.004 · Cited by 136
Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies
Rahman, M. M., Islam, M. R., Shohag, S., Ahasan, M. T., Sarkar, N., Khan, H., Hasan, A. M., Cavalu, S. D., & Rauf, A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112898 · Cited by 133
Effect of Liver Disease on Hepatic Transporter Expression and Function
Thakkar, N., Slizgi, J. R., & Brouwer, K. L. R. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.04.053 · Cited by 127
Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora
Sadrekarimi, H., Gardanova, Z. R., Bakhshesh, M., Ebrahimzadeh, F., Yaseri, A. F., Thangavelu, L. P., Hasanpoor, Z., Zadeh, F. A., & Kahrizi, M. S. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03492-7 · Cited by 131
Bile Acids and Cancer: Direct and Environmental-Dependent Effects
Ciaula, A. D., Wang, D. Q. ‐., Molina‐Molina, E., Baccetto, R., Calamita, G., Palmieri, V. O., & Portincasa, P. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0010.5501 · Cited by 119
Diet and Colorectal Cancer Risk in Asia - a Systematic Review
Azeem, S., Gillani, S. W., Siddiqui, A. A., Jandrajupalli, S. B., Poh, V., & Sulaiman, S. A. S. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.13.5389 · Cited by 115
Diet, microbiota, and dysbiosis: a ‘recipe’ for colorectal cancer
Vipperla, K., & O’Keefe, S. J. (2016) · Food & Function · doi:10.1039/c5fo01276g · Cited by 117
The roles of microbial products in the development of colorectal cancer: a review
Fang, Y., Yan, C., Zhao, Q., Xu, J., Liu, Z., Gao, J., Zhu, H., Dai, Z., Wang, D., & Tang, D. (2021) · Bioengineered · doi:10.1080/21655979.2021.1889109 · Cited by 122
Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
Nagathihalli, N. S., Beesetty, Y., Lee, W., Washington, M. K., Chen, X., Lockhart, A. C., & Merchant, N. B. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2329 · Cited by 112
Mutagenesis by Microbe: the Role of the Microbiota in Shaping the Cancer Genome
Barrett, M., Hand, C. K., Shanahan, F., Murphy, T., & O’Toole, P. W. (2020) · Trends in Cancer · doi:10.1016/j.trecan.2020.01.019 · Cited by 108
DNA Damage, DNA Repair and Cancer
Bernstein, C., Anil, R., Nfonsam, V. N., & Bernstei, H. (2013) · InTech eBooks · doi:10.5772/53919 · Cited by 115
Self-citation
Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science
Inamura, K., Hamada, T., Bullman, S., Ugai, T., Yachida, S., & Ogino, S. (2022) · Gut · doi:10.1136/gutjnl-2022-327209 · Cited by 97
Impact of bile acids on the growth of human cholangiocarcinoma via FXR
Dai, J., Wang, H., Shi, Y. H., Dong, Y., Zhang, Y., & Wang, J. (2011) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-4-41 · Cited by 85
Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes
Xie, G., Wang, X., Zhao, A., Yan, J., Chen, W., Jiang, R., Ji, J., Huang, F., Zhang, Y., Lei, S., et al. (2017) · Scientific Reports · doi:10.1038/srep45232 · Cited by 88
Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma
Chen, Y., Song, X., Valanejad, L., Vasilenko, A., More, V. R., Qiu, X., Chen, W., Lai, Y., Slitt, A. L., Stoner, M. A., et al. (2012) · Hepatology · doi:10.1002/hep.26187 · Cited by 84
Bile acid metabolites control Th17 and Treg cell differentiationPreprint
Hang, S., Paik, D., Devlin, A. S., Trinath, J., Lu, J.-P., Ha, S., Nelson, B. N., Kelly, S. P., Wu, L., Zheng, Y., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/465344 · Cited by 84
Increased Incidence of Gastrointestinal Cancers Among Patients With Pyogenic Liver Abscess: A Population-Based Cohort Study
Lai, H., Lin, C., Cheng, K.-S., Kao, J., Chou, J., Peng, C., Lai, S., Chen, P., & Sung, F. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.09.058 · Cited by 83
Inhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts
Guan, B., Li, H., Yang, Z., Hoque, A. M., & Xu, X. (2012) · Cancer · doi:10.1002/cncr.27910 · Cited by 82
Tumor hijacks macrophages and microbiota through extracellular vesicles
Jiang, J., Mei, J., Ma, Y., Jiang, S., Zhang, J., Yi, S., Feng, C., Liu, Y., & Liu, Y. (2022) · Exploration · doi:10.1002/exp.20210144 · Cited by 84
Cocarcinogenic Effects of Intrahepatic Bile Acid Accumulation in Cholangiocarcinoma Development
Lozano, E., Sanchez‐Vicente, L., Monte, M. J., Herráez, E., Briz, Ó., Bañales, J. M., Marı́n, J. J. G., & Macı́as, R. I. R. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0503 · Cited by 80
Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
Erice, O., Labiano, I., Arbelaiz, A., Santos‐Laso, Á., Muñoz-Garrido, P., Jiménez-Agüero, R., Olaizola, P., Caro‐Maldonado, A., Martín-Martín, N., Carracedo, A., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.016 · Cited by 80
The Immunomodulatory Role of Bile Acids
Sipka, S., & Bruckner, G. G. (2014) · International Archives of Allergy and Immunology · doi:10.1159/000366100 · Cited by 83
Associations between Dietary Patterns and Bile Acids—Results from a Cross-Sectional Study in Vegans and Omnivores
Trefflich, I., Marschall, H., di Giuseppe, R., Ståhlman, M., Michalsen, A., Lampen, A., Abraham, K., & Weikert, C. (2019) · Nutrients · doi:10.3390/nu12010047 · Cited by 81
Cholecystectomy can increase the risk of colorectal cancer: A meta-analysis of 10 cohort studies
Zhang, Y., Liu, H., Li, L., Ai, M., Gong, Z., He, Y., Dong, Y., Xu, S., Wang, J., Jin, B., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181852 · Cited by 77
Gastrointestinal Microbiota and Colon Cancer
Hold, G. L. (2016) · Digestive Diseases · doi:10.1159/000443358 · Cited by 75
A Pilot Study: Changes of Gut Microbiota in Post-surgery Colorectal Cancer Patients
Cong, J., Zhu, H., Liu, D., Li, T., Zhang, C., Zhu, J., Lv, H., Liu, K., Hao, C., Tian, Z., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02777 · Cited by 71
Diagnostic and therapeutic potential of the gut microbiota in patients with early hepatocellular carcinoma
Ponziani, F. R., Nicoletti, A., Gasbarrini, A., & Pompili, M. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919848184 · Cited by 70
Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori–induced inflammation–driven gastric carcinogenesis
Noto, J. M., Piazuelo, M. B., Shah, S. C., Romero–Gallo, J., Hart, J. L., Di, C., Carmichael, J. D., Delgado, A. G., Halvorson, A. E., Greevy, R. A., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci147822 · Cited by 73
Tumor associated macrophage and microbe: The potential targets of tumor vaccine delivery
Jiang, J., Mei, J., Yi, S., Feng, C., Ma, Y., Liu, Y., Liu, Y., & Chen, C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114046 · Cited by 68
Interplay between Dysbiosis of Gut Microbiome, Lipid Metabolism, and Tumorigenesis: Can Gut Dysbiosis Stand as a Prognostic Marker in Cancer?
Chattopadhyay, I., Gundamaraju, R., Jha, N. K., Gupta, P. K., Dey, A., Mandal, C. C., & Ford, B. M. (2022) · Disease Markers · doi:10.1155/2022/2941248 · Cited by 67
Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation
Kresty, L. A., Weh, K. M., Zeyzus-Johns, B., Perez, L. N., & Howell, A. B. (2015) · Oncotarget · doi:10.18632/oncotarget.5586 · Cited by 64
The secondary bile acid, deoxycholate accelerates intestinal adenoma–adenocarcinoma sequence in Apc min/+ mice through enhancing Wnt signaling
Cao, H., Luo, S., Xu, M., Zhang, Y., Song, S., Wang, S., Kong, X., He, N., Cao, X., Yan, F., et al. (2014) · Familial Cancer · doi:10.1007/s10689-014-9742-3 · Cited by 62
Increased Risk of Pancreatic Cancer Related to Gallstones and Cholecystectomy
Fan, Y., Hu, J., Feng, B., Wang, W., Yao, G., Zhai, J., & Li, X. (2015) · Pancreas · doi:10.1097/mpa.0000000000000502 · Cited by 63
Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development
Giammanco, A., Blanc, V., Montenegro, G. A., Klos, C. L., Xie, Y., Kennedy, S., Luo, J., Chang, S.-H., Hla, T., Nalbantoglu, I., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0726 · Cited by 62
Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models
Jena, P. K., Sheng, L., Nagar, N., Wu, C., Barile, D., Mills, D. A., & Wan, Y.-J. Y. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.04.007 · Cited by 60
Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells
Centuori, S. M., Gomes, C. J., Trujillo, J., Borg, J. L., Brownlee, J., Putnam, C. W., & Martinez, J. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.006 · Cited by 58
Host-Gut Microbiota Metabolic Interactions and Their Role in Precision Diagnosis and Treatment of Gastrointestinal Cancers
Cao, C., Yue, S., Lü, A., & Liang, C. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107321 · Cited by 64
Gut microbiota in regulatory T cell generation and function: mechanisms and health implications
Sharma, A., Sharma, G., & Im, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2516702 · Cited by 68
Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases
Stanimirov, B., Stankov, K., & Mikov, M. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(14)60307-6 · Cited by 56
Effects of legume kernel fibres and citrus fibre on putative risk factors for colorectal cancer: a randomised, double-blind, crossover human intervention trial
Fechner, A., Fenske, K., & Jahreis, G. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-101 · Cited by 55
Metabolic profiling of bile in cholangiocarcinoma using in vitro magnetic resonance spectroscopy
Sharif, A. W., Williams, H. R. T., Lampejo, T., Khan, S. A., Bansi, D. S., Westaby, D., Thillainayagam, A. V., Thomas, H. C., Cox, I. J., & Taylor-Robinson, S. D. (2010) · HPB · doi:10.1111/j.1477-2574.2010.00185.x · Cited by 55
Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells
Liao, M., Zhao, J., Wang, T., Duan, J., Zhang, Y., & Deng, X. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-44 · Cited by 54
In Vitro Modeling of Bile Acid Processing by the Human Fecal Microbiota
Martin, G., Kolida, S., Marchesi, J. R., Want, E. J., Sidaway, J. E., & Swann, J. R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01153 · Cited by 55
Trends in incidence of small bowel cancer according to histology: a population-based study
The French Network of Cancer Registries (FRANCIM), Bouvier, A., Robaszkiewicz, M., Jooste, V., Cariou, M., Drouillard, A., Bouvier, V., & Nousbaum, J. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-019-01636-z · Cited by 53
Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis
Yu, L., Cui, A., & Zhang, X. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2348441 · Cited by 54
The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid
Roesly, H. B., Khan, M. R., Chen, H. D. R., Hill, K. A., Narendran, N. H., Watts, G. S., Chen, X. L., & Dvorak, K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00340.2011 · Cited by 53
Self-citation
New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
Caliceti, C., Punzo, A., Silla, A., Simoni, P., Roda, G., & Hrelia, S. (2022) · Nutrients · doi:10.3390/nu14142964 · Cited by 51
Bile Acids Affect the Growth of Human Cholangiocarcinoma via NF-kB Pathway
Dai, J.-Q., Wang, H.-X., Dong, Y., Zhang, Y.-X., & Wang, J. (2013) · Cancer Investigation · doi:10.3109/07357907.2012.762781 · Cited by 47
Exposure of Barrett’s and esophageal adenocarcinoma cells to bile acids activates EGFR–STAT3 signaling axis via induction of APE1
Bhat, A. A., Lu, H., Soutto, M., Capobianco, A. J., Rai, P., Zaika, A., & El-Rifai, W. M. (2018) · Oncogene · doi:10.1038/s41388-018-0388-8 · Cited by 52
p73 protein regulates DNA damage repair
Zaika, E. I., Wei, J., Yin, D., Andl, C. D., Moll, U. M., El-Rifai, W. M., & Zaika, A. I. (2011) · The FASEB Journal · doi:10.1096/fj.11-192815 · Cited by 50
Urinary metabolomics for discovering metabolic biomarkers of bladder cancer by UPLC-MS
Wang, R., Kang, H., Zhang, X., Qing, N., Wang, H., Wang, C., & Zhou, S. (2022) · BMC Cancer · doi:10.1186/s12885-022-09318-5 · Cited by 49
Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications
Sasaki, C., Doukas, S. G., Costa, J., & Vageli, D. (2019) · Cancer · doi:10.1002/cncr.32369 · Cited by 45
Effect of gut flora mediated‐bile acid metabolism on intestinal immune microenvironment
Zhang, Y., Gao, X., Gao, S., Liu, Y., Wang, W., Feng, Y., Pei, L., Sun, Z., Liu, L., & Wang, C. (2023) · Immunology · doi:10.1111/imm.13672 · Cited by 49
Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma?
Sripa, B., Deenonpoe, R., & Brindley, P. J. (2016) · Parasitology International · doi:10.1016/j.parint.2016.11.016 · Cited by 49
Dietary Factors in the Control of Gut Homeostasis, Intestinal Stem Cells, and Colorectal Cancer
Francescangeli, F., Angelis, M. L. D., & Zeuner, A. (2019) · Nutrients · doi:10.3390/nu11122936 · Cited by 51
Current Advance in Small Bowel Tumors
Cheung, D. Y., & Choi, M. (2011) · Clinical Endoscopy · doi:10.5946/ce.2011.44.1.13 · Cited by 47
Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease
Rees, D. O., Crick, P. J., Jenkins, G. J. S., Wang, Y., Griffiths, W. J., Brown, T. H., & Al-Sarireh, B. A. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.10.011 · Cited by 46
Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis
Shao, J., Ge, T., Tang, C., Wang, G., Pang, L., & Chen, Z. (2022) · Inflammation Research · doi:10.1007/s00011-022-01629-4 · Cited by 47

Authors: Bernstein, H., Bernstein, C., Payne, C. M., & Dvorak, K.
Affiliations: Atrium Health Wake Forest Baptist (US)
Corresponding author: Dvorak, Katerina
ORCID: Bernstein, Harris
Bernstein, Carol
Payne, Claire M
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2009
Volume: 15
Issue: 27
Pages: 3329
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.15.3329
PMC: PMC2712893
OpenAlex: W2160363801
Cited by: 340
References: 174
Citations by year: 2026: 18 · 2025: 30 · 2024: 23 · 2023: 27 · 2022: 29 · 2021: 25 · 2020: 13 · 2019: 16 · 2018: 32 · 2017: 13 · 2016: 16 · 2015: 16 · 2014: 20 · 2013: 19 · 2012: 13
FWCI: 14.19
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Arizona Biomedical Research Commission
National Institutes of Health (5r21ca111513-02)
National Cancer Institute (R01CA119087, R21 CA111513, 1P50 CA 95060, R21CA111513-01A1, P50CA095060)
Topics: Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Keywords: bile acids, gastrointestinal cancer, carcinogenesis, esophageal cancer, colorectal cancer, reactive oxygen species, reactive nitrogen species, DNA damage, apoptosis, apoptosis resistance, cancer risk
MeSH terms: Animals, Bile Acids and Salts, Carcinogens, Cell Transformation, Neoplastic, DNA Damage, Female, Gastrointestinal Neoplasms, Humans, Male, Risk Factors, Apoptosis, Reactive Oxygen Species, Receptors, Cytoplasmic and Nuclear

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bile acids as endogenous etiologic agents in gastrointestinal cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks