The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease
Open accessAbstract
Nonalcoholic fatty liver disease (NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAFLD, although the mechanisms underlying this dysfunction are still unclear. Oxidative stress is considered an important factor in producing lethal hepatocyte injury associated with NAFLD. Mitochondrial respiratory chain is the main subcellular source of reactive oxygen species (ROS), which may damage mitochondrial proteins, lipids and mitochondrial DNA. Cardiolipin, a phospholipid located at the level of the inner mitochondrial membrane, plays an important role in several reactions and processes involved in mitochondrial bioenergetics as well as in mitochondrial dependent steps of apoptosis. This phospholipid is particularly susceptible to ROS attack. Cardiolipin peroxidation has been associated with mitochondrial dysfunction in multiple tissues in several physiopathological conditions, including NAFLD. In this review, we focus on the potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction associated with NAFLD.
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Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
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Han, X., Ding, C., Zhang, G., Pan, R., Liu, Y., Huang, N., Hou, N., Han, F., Xu, W., & Sun, X. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.032 · Cited by 63
Huang, B., Liu, J., Fu, S., Zhang, Y., Li, Y., He, D., Ran, X., Yan, X., Du, J., Meng, T., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00281 · Cited by 62
Disease Outcome and Brain Metabolomics of Cyclophilin-D Knockout Mice in Sepsis
Kobayashi, T., Uchino, H., Elmér, E., Ogihara, Y., Fujita, H., Sekine, S., Ishida, Y., Saiki, I., Shibata, S., & Kawachi, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020961 · Cited by 22
Metadata
- Authors
- Paradies, G.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 20
- Issue
- 39
- Pages
- 14205
- ISSN
- 1007-9327 (ISSN-L)
- OpenAlex
- W2092162941
- Cited by
- 500
- References
- 23
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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