Cited by 509Inflammatory Bowel DiseaseBarrier Structure and Function StudiesCell Adhesion Molecules Research

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Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

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Landy, Jonathan, Ronde, Emma, English, Nick, Clark, Sue K, Hart, Ailsa L, Knight, Stella C, Ciclitira, Paul J, Al-Hassi, Hafid Omar·2016·World Journal of Gastroenterology

DOI 10.3748/wjg.v22.i11.3117PMC PMC4789987

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Abstract

Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.

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Authors: Landy, J., Ronde, E., English, N., Clark, S. K., Hart, A. L., Knight, S. C., Ciclitira, P. J., & Al-Hassi, H. O.
Affiliations: St Mark's Hospital (GB)
St Thomas' Hospital (GB)
Corresponding author: Ciclitira, Paul J
ORCID: Ronde, Emma
Hart, Ailsa L
Knight, Stella C
Ciclitira, Paul J
Al-Hassi, Hafid Omar
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2016
Volume: 22
Issue: 11
Pages: 3117
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v22.i11.3117
PMC: PMC4789987
OpenAlex: W2330707041
Cited by: 507
References: 103
Citations by year: 2026: 38 · 2025: 56 · 2024: 65 · 2023: 60 · 2022: 65 · 2021: 69 · 2020: 49 · 2019: 39 · 2018: 39 · 2017: 20 · 2016: 7
FWCI: 4.68
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Spiral (Imperial College London) (submittedVersion, other-oa)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: tight junctions, inflammatory bowel disease, inflammatory bowel disease-associated colorectal cancer, claudins, intestinal epithelial barrier, paracellular permeability, intestinal inflammation, pathogenesis
MeSH terms: Animals, Anti-Inflammatory Agents, Colitis, Ulcerative, Colon, Crohn Disease, Humans, Intestinal Mucosa, Permeability, Colorectal Neoplasms, Inflammation Mediators, Tight Junctions, Pouchitis, Claudins

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Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

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