Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

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Infliximab for Induction and Maintenance Therapy for Ulcerative Colitis

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Intestinal barrier function: molecular regulation and disease pathogenesis

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Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

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Claudin-based tight junctions are crucial for the mammalian epidermal barrier

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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

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Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

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Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

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Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

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Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2

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Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

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Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein claudin-1 transcription

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Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

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Histologic Inflammation Is a Risk Factor for Progression to Colorectal Neoplasia in Ulcerative Colitis: A Cohort Study

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Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

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THE COLONIC EPITHELIUM IN ULCERATIVE COLITIS: AN ENERGY-DEFICIENCY DISEASE?

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Microbiota organization is a distinct feature of proximal colorectal cancers

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Importance of disrupted intestinal barrier in inflammatory bowel diseases

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Intestinal permeability and the prediction of relapse in Crohn's disease

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γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

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Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis

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Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability

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Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function

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Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

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Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut

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Neutrophil Transmigration in Inflammatory Bowel Disease Is Associated with Differential Expression of Epithelial Intercellular Junction Proteins

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Structure, function, and regulation of cellular tight junctions

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Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells

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Occludin: Structure, function and regulation

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Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation

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A porous defense: the leaky epithelial barrier in intestinal disease

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Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis

Su, L., Shen, L., Clayburgh, D. R., Nalle, S. C., Sullivan, E. A., Meddings, J. B., Abraham, C., & Turner, J. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.081 · Cited by 455

Claudin-2, a component of the tight junction, forms a paracellular water channel

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Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism

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Barriers built on claudins

Turksen, K., & Troy, T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01235 · Cited by 403

Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease

Suenaert, P., Bulteel, V., Lemmens, L., Noman, M., Geypens, B. J., Assche, G. V., Geboes, K. J., Ceuppens, J. L., & Rutgeerts, P. J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05914.x · Cited by 402

Epithelial Tight Junctions in Intestinal Inflammation

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A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease

Zolotarevsky, Y., Hecht, G. A., Koutsouris, A., Gonzalez, D. E., Quan, C., Tom, J., Mrsny, R. J., & Turner, J. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.34235 · Cited by 385

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

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Zonulin, regulation of tight junctions, and autoimmune diseases

Fasano, A. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06538.x · Cited by 365

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

Shen, L., Weber, C. R., & Turner, J. R. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711165 · Cited by 361

Biology of claudins

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Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function

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The tight junction in inflammatory disease: communication breakdown

Edelblum, K. L., & Turner, J. R. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.06.022 · Cited by 328

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

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Tight junction, selective permeability, and related diseases

Krug, S. M., Schulzke, J. D., & Fromm, M. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.002 · Cited by 307

Downregulation of epithelial apoptosis and barrier repair in active Crohn’s disease by tumour necrosis factor α antibody treatment

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Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease

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Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

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The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT‐1001 in coeliac disease subjects: a proof of concept study

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Crohn's disease--a permeability disorder of the tight junction?

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Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging

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Bifidobacteria Stabilize Claudins at Tight Junctions and Prevent Intestinal Barrier Dysfunction in Mouse Necrotizing Enterocolitis

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Establishment and Characterization of Cultured Epithelial Cells Lacking Expression of ZO-1

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Clustering of increased small intestinal permeability in families with Crohn's disease

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Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes

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Butyrate utilization by the colonic mucosa in inflammatory bowel diseases

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Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives.

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TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

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Inflammatory Bowel Disease and the Apical Junctional Complex

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Intestinal Permeability Test As A Predictor of Clinical Course in Crohn's Disease

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Changes in the expression of claudins in active ulcerative colitis

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Increase in the Tight Junction Protein Claudin-1 in Intestinal Inflammation

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Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells

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Quercetin Enhances Epithelial Barrier Function and Increases Claudin-4 Expression in Caco-2 Cells3

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Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation

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Microarray Analysis of Butyrate Regulated Genes in Colonic Epithelial Cells

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Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice

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Interferon-γ selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores

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Claudins of intestine and nephron – a correlation of molecular tight junction structure and barrier function

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Differential expression of claudin‐2 along the human intestine: Implication of GATA‐4 in the maintenance of claudin‐2 in differentiating cells

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Junctions gone bad: Claudins and loss of the barrier in cancer

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Inflammatory bowel disease: is it really just another break in the wall?: Figure 1

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Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-α on tight junction proteins and signaling pathways in intestinal epithelial cells

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Expression profiling of claudins in the human gastrointestinal tract in health and during inflammatory bowel disease

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AMP-activated Protein Kinase Mediates the Interferon-γ-induced Decrease in Intestinal Epithelial Barrier Function

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n-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines

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Ultrastructural differences in junctional intercellular communication between highly and weakly metastatic clones derived from rat mammary carcinoma.

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Comparative tight junction protein expressions in colonic Crohn’s disease, ulcerative colitis, and tuberculosis: a new perspective

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Adherent-Invasive Escherichia coli Induce Claudin-2 Expression and Barrier Defect in CEABAC10 Mice and Crohnʼs Disease Patients§

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Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and β-catenin

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Claudin‐8 modulates paracellular permeability to acidic and basic ions in MDCK II cells

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Salmonella Infection Upregulates the Leaky Protein Claudin-2 in Intestinal Epithelial Cells

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Barrier Effects of Nutritional Factors

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Claudins and paracellular transport: an update

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