Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

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Infliximab for Induction and Maintenance Therapy for Ulcerative Colitis

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Intestinal barrier function: molecular regulation and disease pathogenesis

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Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

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Claudin-based tight junctions are crucial for the mammalian epidermal barrier

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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

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Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

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Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

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Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

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The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier

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miR-195-5p Regulates Tight Junctions Expression via Claudin-2 Downregulation in Ulcerative Colitis

Scalavino, V., Piccinno, E., Lacalamita, A., Tafaro, A., Armentano, R., Giannelli, G., & Serino, G. (2022) · Biomedicines · doi:10.3390/biomedicines10040919 · Cited by 26

Predominant Distribution of the RNAi Machinery at Apical Adherens Junctions in Colonic Epithelia Is Disrupted in Cancer

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Interaction of Companilactobacillus crustorum MN047-derived bacteriocins with gut microbiota

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Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism

Ji, Z., He, S., Xie, W., Zhao, P., Ren, W., Gao, W., & Yuan, B. (2023) · Nutrients · doi:10.3390/nu15234877 · Cited by 26

Diet, food components and the intestinal barrier

Gleeson, J. P. (2017) · Nutrition Bulletin · doi:10.1111/nbu.12260 · Cited by 25

Lactobacillus-derived metabolites enhance the antitumor activity of 5-FU and inhibit metastatic behavior in 5-FU-resistant colorectal cancer cells by regulating claudin-1 expression

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Micronutrient Improvement of Epithelial Barrier Function in Various Disease States: A Case for Adjuvant Therapy

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Bletilla striata Oligosaccharides Improve Ulcerative Colitis by Regulating Gut Microbiota and Intestinal Metabolites in Dextran Sulfate Sodium-Induced Mice

Zhu, T., Hu, B., Ye, C., Hu, H., Yin, M., Zhang, Z., Li, S., Liu, Y., & Liu, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.867525 · Cited by 24

Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS ‐induced colitis via intestinal barrier protection and gut microbiota modulation in mice

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Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn’s disease

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Sini San ameliorates duodenal mucosal barrier injury and low‑grade inflammation via the CRF pathway in a rat model of functional dyspepsia

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IL-22-Activated MUC13 Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling

Breugelmans, T., Arras, W., Oosterlinck, B., Jauregui-Amezaga, A., Somers, M. J. G., Cuypers, B., Laukens, K., Man, J. G. D., Schepper, H. U. D., Winter, B. Y. D., et al. (2023) · Cells · doi:10.3390/cells12091224 · Cited by 23

Claudin‐targeted drug development using anti‐claudin monoclonal antibodies to treat hepatitis and cancer

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Intestinal anti-inflammatory activity of xique–xique ( Pilosocereus gounellei A. Weber ex K. Schum. Bly. Ex Rowl) juice on acetic acid-induced colitis in rats

de Assis, P. O. A., Guerra, G. C. B., Araújo, D. F. D. S., Interaminense, L. F. L., de Araújo, A. A., Júnior, R. F. D. A., de Carvalho, T. G., de Souza, M. D. F. V., Borges, G. D. S. C., Lima, M. D. S., et al. (2019) · Food & Function · doi:10.1039/c9fo00920e · Cited by 25

Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function

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Effect of Crohn’s Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine

Vyhlidal, C. A., Chapron, B. D., Ahmed, A. A., Singh, V., Casini, R., & Shakhnovich, V. (2020) · Clinical and Translational Science · doi:10.1111/cts.12938 · Cited by 23

Effects of Wine and Its Microbial-Derived Metabolites on Intestinal Permeability Using Simulated Gastrointestinal Digestion/Colonic Fermentation and Caco-2 Intestinal Cell Models

Zorraquín‐Peña, I., Taladrid, D., Tamargo, A., Silva, M., Molinero, N., de Llano, D. G., Bartolomé, B., & Moreno-Arribas, M. V. (2021) · Microorganisms · doi:10.3390/microorganisms9071378 · Cited by 23

Hypermethylation of miR-145 promoter-mediated SOX9-CLDN8 pathway regulates intestinal mucosal barrier in Crohn's disease

Zhuang, X., Chen, B., Huang, S., Han, J., Zhou, G., Xu, S., Chen, M., Zeng, Z., & Zhang, S. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103846 · Cited by 23

Resveratrol Attenuates Ankylosing Spondylitis in Mice by Inhibiting the TLR4/NF-κB/NLRP3 Pathway and Regulating Gut Microbiota

Ding, M.-H., Xu, P.-G., Wang, Y., Ren, B.-D., & Zhang, J. (2022) · Immunological Investigations · doi:10.1080/08820139.2022.2154162 · Cited by 23

Orally Administrable H 2 S‐Scavenging Metal–Organic Framework Prepared by Co‐Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu

Dou, Y., Liu, P., Ding, Z., Zhou, Y. X., Jing, H., Ren, Y., Heger, Z., Adam, V., & Li, N. (2023) · Advanced Materials · doi:10.1002/adma.202210047 · Cited by 23

Intestinal barrier tightening by a cell‐penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis

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Human organoids are superior to cell culture models for intestinal barrier research

Kollmann, C., Buerkert, H., Meir, M., Richter, K., Kretzschmar, K., Flemming, S., Kelm, M., Germer, C., Otto, C., Burkard, N., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1223032 · Cited by 22

Interaction between gut microbiota and immunity in health and intestinal disease

Wang, Q., Meng, Q., Chen, Y., Liu, Y., Li, X., Zhou, J., Ma, Y., Yu, Z., & Chen, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1673852 · Cited by 34

Association of Emulsifier and Highly Processed Food Intake with Circulating Markers of Intestinal Permeability and Inflammation in the Cancer Prevention Study-3 Diet Assessment Sub-Study

Um, C. Y., Hodge, R. A., Tran, H. Q., Campbell, P. T., Gewirtz, A. T., & McCullough, M. L. (2021) · Nutrition and Cancer · doi:10.1080/01635581.2021.1957947 · Cited by 22

The role of morphine‐ and fentanyl‐induced impairment of intestinal epithelial antibacterial activity in dysbiosis and its impact on the microbiota‐gut‐brain axis

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Walnut peptide ameliorates DSS-induced colitis in mice by inhibiting inflammation and modulating gut microbiota

Guo, H., Ji, Z., Wang, B., Ren, J.-W., Gao, W., & Yuan, B. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106344 · Cited by 22

Acute infection with the intestinal parasite Trichuris muris has long‐term consequences on mucosal mast cell homeostasis and epithelial integrity

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Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease

Zhu, X., Wang, J., Zhang, H., Yue, H., Zhu, J., Li, J., Wang, K., Shen, K., Yang, K., Leng, X., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05514-7 · Cited by 21

Calcium/calmodulin–dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation

Cunningham, K. E., Novak, E. A., Vincent, G., Siow, V. S., Griffith, B. D., Ranganathan, S., Rosengart, M. R., Piganelli, J. D., & Mollen, K. P. (2018) · The FASEB Journal · doi:10.1096/fj.201800535r · Cited by 21

Masticadienonic acid from Chios mastic gum mitigates colitis in mice via modulating inflammatory response, gut barrier integrity and microbiota

Cui, H., Li, X., An, X.-R., Liu, W., & Yuan, T. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154518 · Cited by 21

Intracellular Polysaccharides of Aspergillus cristatus from Fuzhuan Brick Tea Leverage the Gut Microbiota and Repair the Intestinal Barrier to Ameliorate DSS-Induced Colitis in Mice

Xie, Z., Zeng, Z., Chen, G., Dong, W., Peng, Y., Xu, W., Sun, Y., Zeng, X., & Liu, Z. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00611 · Cited by 21

The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation

Cox, C. M., Lu, R., Salcin, K., & Wilson, J. M. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.11.001 · Cited by 21

Role of Mitochondria in Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease

Chernyavskij, D. A., Galkin, I. I., Pavlyuchenkova, A. N., Fedorov, A. V., & Chelombitko, M. A. (2023) · Molecular Biology · doi:10.1134/s0026893323060043 · Cited by 22

Modulation of Serotonin-Related Genes by Extracellular Vesicles of the Probiotic Escherichia coli Nissle 1917 in the Interleukin-1β-Induced Inflammation Model of Intestinal Epithelial Cells

Olivo-Martínez, Y., Martínez-Ruiz, S., Cordero-Alday, C., Bosch, M., Badía, J., & Baldomà, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105338 · Cited by 21

Pulsatilla decoction alleviates colitis by enhancing autophagy and regulating PI3K‑Akt‑mTORC1 signaling pathway

Wang, X., Xu, L., Wang, T., Xu, J., Fan, F., Zhang, Y., Wang, J., & Cao, Q. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12624 · Cited by 19

Disruption to tRNA Modification by Queuine Contributes to Inflammatory Bowel Disease

Zhang, J., Zhang, Y., McGrenaghan, C. J., Kelly, V. P., Xia, Y., & Sun, J. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.02.006 · Cited by 22

Interactions between enzyme preparations and trace element sources on growth performance and intestinal health of broiler chicks

Cao, J., Guo, Y., Luo, X., Ge, C., Hu, Z., Wu, L., Lv, Y., Lin, G., Yu, D., & Liu, B. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103124 · Cited by 19

Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway

Qu, X., Song, Y., Li, Q., Xu, Q., Li, Y., Zhang, H., Cheng, X., Mackay, C. R., Wang, Q., & Liu, W. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01488-z · Cited by 23

Dietary Protease Supplementation Improved Growth Performance and Nutrients Digestion via Modulating Intestine Barrier, Immunological Response, and Microbiota Composition in Weaned Piglets

Liu, T., Ma, W., Wang, J., Wei, Y., Wang, Y., Luo, Z., Zhang, Y., Zeng, X., Guan, W., Shao, D., et al. (2024) · Antioxidants · doi:10.3390/antiox13070816 · Cited by 19

Zinc ions regulate opening of tight junction favouring efflux of macromoleculesviathe GSK3β/snail-mediated pathway

Xiao, R., Yuan, L., He, W., & Yang, X. (2017) · Metallomics · doi:10.1039/c7mt00288b · Cited by 18

Lignosulfonic acid attenuates NF-κB activation and intestinal epithelial barrier dysfunction induced by TNF-α/IFN-γ in Caco-2 cells

Matsuhisa, K., Watari, A., Iwamoto, K., Kondoh, M., & Yagi, K. (2017) · Journal of Natural Medicines · doi:10.1007/s11418-017-1167-5 · Cited by 19

Neurexophilin and PC‐esterase domain family member 4 ( NXPE4 ) and prostate androgen‐regulated mucin‐like protein 1 ( PARM1 ) as prognostic biomarkers for colorectal cancer

Liu, Y., Hu, Y., Zeng, Y., Li, Z., Zhang, H., Deng, J., & Wang, G. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29107 · Cited by 19

Improvement of magnesium isoglycyrrhizinate on DSS-induced acute and chronic colitis

Cui, J., Li, Y., Jiao, C., Gao, J., He, Y., Nie, B., Kong, L., Guo, W., & Xu, Q. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107194 · Cited by 19

Kaiso-induced intestinal inflammation is preceded by diminished E-cadherin expression and intestinal integrity

Robinson, S. C., Chaudhary, R., Jiménez‐Saiz, R., Rayner, L. G. A., Bayer, L., Jordana, M., & Daniel, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217220 · Cited by 16

Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche

Lim, R., Banerjee, A., Biswas, R., Chari, A. N., & Raghavan, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.966662 · Cited by 21

Ganoderma lucidum Ethanol Extraction Promotes Dextran Sulphate Sodium Induced Colitis Recovery and Modulation in Microbiota

Li, M., Yu, L., Zhai, Q., Liu, B., Zhao, J., Chen, W., & Tian, F. (2022) · Foods · doi:10.3390/foods11244023 · Cited by 18

Treatment with S-adenosylmethionine ameliorates irinotecan-induced intestinal barrier dysfunction and intestinal microbial disorder in mice

Xiao, L., Dou, W., Wang, Y., Deng, H., Xu, H., & Pan, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115752 · Cited by 18

Keeping it tight: The relationship between bacterial dysbiosis, septate junctions, and the intestinal barrier in Drosophila

Resnik-Docampo, M., Sauer, V., Schinaman, J. M., Clark, R. I., Walker, D. W., & Jones, D. L. (2018) · Fly · doi:10.1080/19336934.2018.1441651 · Cited by 18

Serum amino acid profile in 51 dogs with immunosuppressant-responsive enteropathy (IRE): a pilot study on clinical aspects and outcomes

Benvenuti, E., Pierini, A., Gori, E., Bartoli, F., Erba, P. A., Ruggiero, P., & Marchetti, V. (2020) · BMC Veterinary Research · doi:10.1186/s12917-020-02334-2 · Cited by 18

A piglet model of iatrogenic rectosigmoid hypoganglionosis reveals the impact of the enteric nervous system on gut barrier function and microbiota postnatal development

Arnaud, A. P., Hascoët, J., Berneau, P., Gouevec, F. L., Georges, J., Randuineau, G., Formal, M., Henno, S., & Boudry, G. (2020) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2020.06.018 · Cited by 17

Estrogen deficiency aggravates fluoride-induced small intestinal mucosa damage and junctional complexes proteins expression disorder in rats

Jin, Y., Gao, X.-Y., Zhao, J., Tian, W., Zhang, Y., Tian, E., Zhou, B.-H., & Wang, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114181 · Cited by 17

Magnolia officinalis Bark Extract Prevents Enterocyte Death in a Colitis Mouse Model by Inhibiting ROS-Mediated Necroptosis

Lee, K.-I., Kim, H. J., Kim, H., Kim, M., Kim, J. I., & Park, K.-S. (2022) · Antioxidants · doi:10.3390/antiox11122435 · Cited by 17

Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity

Francis, K. L., Alonge, K. M., Pacheco, M. C., HU, S. J. W., KRUTZSCH, C. A., Morton, G. J., Schwartz, M. W., & Scarlett, J. M. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i33.4991 · Cited by 17

Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis

Erkert, L., Gámez‐Belmonte, R., Kabisch, M., Schödel, L., Patankar, J. V., González-Acera, M., Mahapatro, M., Bao, L., Plattner, C., Kühl, A. A., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-331622 · Cited by 17

Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Function via Tight Junction Recovery and Reduces Inflammation

Yang, Y. J., Kim, M. O., Lee, H. J., Lee, W.-Y., Yang, J.-H., Kim, H., Shim, M., Heo, J., Son, J. D., Kim, W. H., et al. (2024) · Antioxidants · doi:10.3390/antiox13050575 · Cited by 17

Partial to complete abrogation of the subepithelial macrophage barrier against the gut microbiota in patients with ulcerative colitis and Crohn's colitis

Rubio, C. A., Langner, C., & Schmidt, P. T. (2017) · Histopathology · doi:10.1111/his.13417 · Cited by 17

Impaired Colonic Contractility and Intestinal Permeability in Symptomatic Uncomplicated Diverticular Disease

Altomare, A., Gori, M., Cocca, S., Carotti, S., Francesconi, M. A., Ribolsi, M., Emerenziani, S., Perrone, G., Morini, S., Cicala, M., et al. (2021) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20110 · Cited by 17

SlpB Protein Enhances the Probiotic Potential of L. lactis NCDO 2118 in Colitis Mice Model

Belo, G. A., Cordeiro, B. F., Oliveira, E. R., Braga, M. P., da Silva, S. H., Costa, B. G., Martins, F. S., Jan, G., Loir, Y. L., Gala-García, A., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.755825 · Cited by 17

cRGD peptide incorporated with patchouli alcohol loaded silk fibroin nanoparticles for enhanced targeting of inflammatory sites in colitis

Du, Y., Shi, J., Duan, R., Tsim, K. W. K., Shen, L., Zhang, N., & Wang, B. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213069 · Cited by 17

Effects of human induced pluripotent stem cell-derived intestinal organoids on colitis-model mice

Nakanishi, A., Toyama, S., Onozato, D., Watanabe, C., Hashita, T., Iwao, T., & Matsunaga, T. (2022) · Regenerative Therapy · doi:10.1016/j.reth.2022.08.004 · Cited by 16

Efficacy and Mechanism of the Action of Live and Heat-Killed Bacillus coagulans BC198 as Potential Probiotic in Ameliorating Dextran Sulfate Sodium-Induced Colitis in Mice

Koh, Y., Chang, Y., Lin, W., Leung, S.-Y., Chen, W. J., Wu, S.-H., Wei, Y., Gung, C.-L., Chou, Y.-C., & Pan, M. (2024) · ACS Omega · doi:10.1021/acsomega.3c07529 · Cited by 17

Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota

Guo, H., Wang, B., Wu, H., Feng, H.-Y., Zhang, H., Gao, W., & Yuan, B. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112024 · Cited by 16

Polyphenols from Foxtail Millet Improve Non-Alcoholic Fatty Liver Disease by Regulating Intestinal Microbiome in Mice

Israr, G., An, Y., Qiao, Q., He, S., & Li, Z. (2024) · Foods · doi:10.3390/foods13111683 · Cited by 16

Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α–Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex–Dependent Stimulation of Peroxisome Proliferator-Activated Receptor γ and Suppression of NF-κB p65

Abdulqadir, R. F., Al–Sadi, R., Haque, M. R., Gupta, Y., Rawat, M., & Ma, T. Y. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.05.012 · Cited by 19

Knockdown of ghrelin‐ O ‐acyltransferase attenuates colitis through the modulation of inflammatory factors and tight junction proteins in the intestinal epithelium

Tian, P., Lu, X., Jin, N., & Shi, J. (2020) · Cell Biology International · doi:10.1002/cbin.11362 · Cited by 16

Increase in Epithelial Permeability and Cell Metabolism by High Mobility Group Box 1, Inflammatory Cytokines and TPEN in Caco-2 Cells as a Novel Model of Inflammatory Bowel Disease

Miyakawa, M., Konno, T., Kohno, T., Kikuchi, S., Tanaka, H., & Kojima, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228434 · Cited by 17

Protective Role of Coxsackie-Adenovirus Receptor in the Pathogenesis of Inflammatory Bowel Diseases

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Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics

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