The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer
Open accessAbstract
The human intestinal microbiome plays a major role in human health and diseases, including colorectal cancer. Colorectal carcinogenesis represents a heterogeneous process with a differing set of somatic molecular alterations, influenced by diet, environmental and microbial exposures, and host immunity. Fusobacterium species are part of the human oral and intestinal microbiota. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue. Using 511 colorectal carcinomas from Japanese patients, we assessed the presence of F. nucleatum. Our results showed that the frequency of F. nucleatum positivity in the Japanese colorectal cancer was 8.6% (44/511), which was lower than that in United States cohort studies (13%). Similar to the United States studies, F. nucleatum positivity in Japanese colorectal cancers was significantly associated with microsatellite instability (MSI)-high status. Regarding the immune response in colorectal cancer, high levels of infiltrating T-cell subsets (i.e., CD3+, CD8+, CD45RO+, and FOXP3+ cells) have been associated with better patient prognosis. There is also evidence to indicate that molecular features of colorectal cancer, especially MSI, influence T-cell-mediated adaptive immunity. Concerning the association between the gut microbiome and immunity, F. nucleatum has been shown to expand myeloid-derived immune cells, which inhibit T-cell proliferation and induce T-cell apoptosis in colorectal cancer. This finding indicates that F. nucleatum possesses immunosuppressive activities by inhibiting human T-cell responses. Certain microRNAs are induced during the macrophage inflammatory response and have the ability to regulate host-cell responses to pathogens. MicroRNA-21 increases the levels of IL-10 and prostaglandin E2, which suppress antitumor T-cell-mediated adaptive immunity through the inhibition of the antigen-presenting capacities of dendritic cells and T-cell proliferation in colorectal cancer cells. Thus, emerging evidence may provide insights for strategies to target microbiota, immune cells and tumor molecular alterations for colorectal cancer prevention and treatment. Further investigation is needed to clarify the association of Fusobacterium with T-cells and microRNA expressions in colorectal cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“supporting studies reporting that F nucleatum reduces the anti-tumor immune response.”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [29]
In the citing paper
“Moreover, levels of F nucleatum in tumor tissue have been associated with lower infiltration by T cells,29, 30”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320
The blockade of immune checkpoints in cancer immunotherapy
Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838
PD-1 blockade induces responses by inhibiting adaptive immune resistance
Tumeh, P. C., Harview, C. L., Yearley, J. H., Shintaku, I. P., Taylor, E. J. M., Robert, L., Chmielowski, B., Spasic, M., Henry, G., Ciobanu, V., et al. (2014) · Nature · doi:10.1038/nature13954 · Cited by 6,609
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
Herbst, R. S., Soria, J.-C., Kowanetz, M., Fine, G. D., Hamid, O., Gordon, M. S., Sosman, J. A., McDermott, D. F., Powderly, J. D., Gettinger, S. N., et al. (2014) · Nature · doi:10.1038/nature14011 · Cited by 5,231
The immune contexture in human tumours: impact on clinical outcome
Fridman, W. H., Pagès, F., Sautès-Fridman, C., & Galon, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3245 · Cited by 4,981
Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
Snyder, A., Makarov, V., Merghoub, T., Yuan, J., Zaretsky, J. M., Desrichard, A., Walsh, L. A., Postow, M. A., Wong, P., Ho, T. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1406498 · Cited by 4,286
Nivolumab plus Ipilimumab in Advanced Melanoma
Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230
Molecular and genetic properties of tumors associated with local immune cytolytic activity
Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G., & Hacohen, N. (2015) · Cell · doi:10.1016/j.cell.2014.12.033 · Cited by 3,825
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 343
Diverticular Disease: a Gut Microbiota Perspective
Ticinesi, A., Nouvenne, A., Corrente, V., Tana, C., Mario, F. D., & Meschi, T. (2019) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-277 · Cited by 48
The pathogenic oral–gut–liver axis: new understandings and clinical implications
Imai, J., Kitamoto, S., & Kamada, N. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1935877 · Cited by 46
Contribution of Immunoscore and Molecular Features to Survival Prediction in Stage III Colon Cancer
Sinicrope, F. A., Shi, Q., Hermitte, F., Zemla, T., Mlecnik, B., Benson, A. B., Gill, S., Goldberg, R. M., Kahlenberg, M. S., Nair, S., et al. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa023 · Cited by 43
Interaction between microbiota and immunity and its implication in colorectal cancer
Xing, C., Du, Y., Duan, T., Nim, K., Chu, J., Wang, H. Y., & Wang, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.963819 · Cited by 47
Gut Microbiota and Tumor Immune Escape: A New Perspective for Improving Tumor Immunotherapy
He, Y., Huang, J., Li, Q., Xia, W., Zhang, C., Liu, Z., Xiao, J., Yi, Z., Deng, H., Xiao, Z., et al. (2022) · Cancers · doi:10.3390/cancers14215317 · Cited by 47
Salvucci, M., Crawford, N., Stott, K. J., Bullman, S., Longley, D. B., & Prehn, J. H. M. (2021) · Gut · doi:10.1136/gutjnl-2021-325193 · Cited by 42
Shamekhi, S., Lotfi, H., Abdolalizadeh, J., Bonabi, E., & Zarghami, N. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-019-02270-0 · Cited by 44
Exploring the Inflammatory Pathogenesis of Colorectal Cancer
Khalyfa, A. A., Punatar, S., Aslam, R., & Yarbrough, A. (2021) · Diseases · doi:10.3390/diseases9040079 · Cited by 44
Iadsee, N., Chuaypen, N., Techawiwattanaboon, T., Jinato, T., Patcharatrakul, T., Malakorn, S., Petchlorlian, A., Praditpornsilpa, K., & Patarakul, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-33794-9 · Cited by 45
A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century
Kumar, R., Harilal, S., Carradori, S., & Mathew, B. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666201026143757 · Cited by 44
Emerging Role of Immunotherapy for Colorectal Cancer with Liver Metastasis
Yu, X., Zhu, L., Liu, J., Xie, M., Chen, J., & Li, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s271955 · Cited by 43
The triple interactions between gut microbiota, mycobiota and host immunity
Yang, J., Yang, H., & Li, Y. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2094888 · Cited by 44
Luo, R., Chang, Y., Liang, H., Zhang, W., Song, Y., Li, G., & Cao, Y. (2023) · iMeta · doi:10.1002/imt2.86 · Cited by 41
The Gut Microbiome Advances Precision Medicine and Diagnostics for Inflammatory Bowel Diseases
Mousa, W. K., & Ali, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011259 · Cited by 50
Hsieh, Y., Kuo, W.-L., Hsu, W.-T., Tung, S., & Li, C. (2022) · Cancers · doi:10.3390/cancers15010269 · Cited by 38
Murray, P. E., Coffman, J. A., & Garcı́a-Godoy, F. (2024) · Pathogens · doi:10.3390/pathogens13121084 · Cited by 46
Oral microbiota and gastrointestinal cancer
Zhang, Y., Niu, Q., Fan, W., Huang, F. P., & He, H. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s194153 · Cited by 39
Pan, S., Guo, Y., Hong, F., Xu, P., & Zhai, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166281 · Cited by 37
Chr20q Amplification Defines a Distinct Molecular Subtype of Microsatellite Stable Colorectal Cancer
Zhang, B., Yao, K., Zhou, E., Zhang, L., & Cheng, C. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-4009 · Cited by 36
Fusobacterium nucleatum, the communication with colorectal cancer
Luo, K., Zhang, Y., Xv, C., Ji, J., Lou, G., Guo, X., Chen, M., Zhang, Y., Wei, H., Guo, M., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108988 · Cited by 38
Increasing Fusobacterium infections with Fusobacterium varium, an emerging pathogen
Lee, S. J., Baek, Y. J., Kim, J. N., Lee, K. H., Lee, E. H., Yeom, J., Choi, J. Y., Ku, N. S., Ahn, J. Y., Kim, J. H., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266610 · Cited by 36
Exploring the microbiota to better understand gastrointestinal cancers physiology
Panebianco, C., Potenza, A., Andriulli, A., & Pazienza, V. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-1163 · Cited by 46
Kashani, N., Abadi, A. T. B., Rahimi, F., & Forootan, M. (2020) · New Microbes and New Infections · doi:10.1016/j.nmni.2020.100651 · Cited by 37
Chang, H., Mishra, R., Cen, C., Tang, Y., Ma, C., Wasti, S., Wang, Y., Ou, Q., Chen, K., & Zhang, J. (2021) · Current Microbiology · doi:10.1007/s00284-020-02299-3 · Cited by 35
Salivary Microbiota Composition in Patients with Oral Squamous Cell Carcinoma: A Systematic Review
Mauceri, R., Coppini, M., Vacca, D., Bertolazzi, G., Panzarella, V., Fede, O. D., Tripodo, C., & Campisi, G. (2022) · Cancers · doi:10.3390/cancers14215441 · Cited by 35
Yamane, T., Kanamori, Y., Sawayama, H., Yano, H., Nita, A., Ohta, Y., Hinokuma, H., Maeda, A., Iwai, A., Matsumoto, T., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.156802 · Cited by 33
Zhuang, Y.-P., Zhou, H., Chen, H., Zheng, M.-Y., Liang, Y., Gu, Y.-T., Li, W., Qiu, W., & Zhou, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115040 · Cited by 34
An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps
Pop, O. L., Vodnar, D. C., Diaconeasa, Z. M., Istrati, M., Bințințan, A., Bintintan, V. V., Suharoschi, R., & Gabbianelli, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197359 · Cited by 34
Zhao, L., Zhang, X., Zuo, T., & Yu, J. Q. (2017) · Engineering · doi:10.1016/j.eng.2017.01.012 · Cited by 35
Altered Gut Microbiota in Patients With Peutz-Jeghers Syndrome
Wan, S., Huang, G., Wang, J.-X., Tian, L., Zuo, X., Li, Y., & Yu, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.881508 · Cited by 31
Study Insights into Gastrointestinal Cancer through the Gut Microbiota
Kong, F., & Cai, Y. (2019) · BioMed Research International · doi:10.1155/2019/8721503 · Cited by 33
The oral-gut-circulatory axis: from homeostasis to colon cancer
Tortora, S. C., Agurto, M. I. G., & Martello, L. A. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1289452 · Cited by 34
Tumor Potentiating Mechanisms of Fusobacterium nucleatum , A Multifaceted Microbe
Holt, R. A., & Cochrane, K. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.024 · Cited by 31
Multifaceted Impacts of Periodontal Pathogens in Disorders of the Intestinal Barrier
Liu, Y., Huang, W., Wang, J., Ma, J., Zhang, M., Lü, X., Liu, J., & Kou, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.693479 · Cited by 34
EnsDeepDP: An Ensemble Deep Learning Approach for Disease Prediction Through Metagenomics
Shen, Y., Zhu, J., Deng, Z., Lu, W., & Wang, H. (2022) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2022.3201295 · Cited by 32
Tumor-resident microbes: the new kids on the microenvironment block
Li, L., Chandra, V., & McAllister, F. (2024) · Trends in Cancer · doi:10.1016/j.trecan.2023.12.002 · Cited by 30
The Gastric Microbiome and Its Influence on Gastric Carcinogenesis
Zhang, C., Powell, S. E., Betel, D., & Shah, M. A. (2017) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2017.01.002 · Cited by 30
Garraway, K., Johannes, C. M., Bryan, A., Peauroi, J. R., Rossi, G., Zhang, M., Wang, C., Allenspach, K., & Jergens, A. E. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15291 · Cited by 30
Alterations of the Oral Microbiota Profiles in Chinese Patient With Oral Cancer
Li, Z., Chen, G., Wang, P., Sun, M., Zhao, J., Li, A., & Sun, Q. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.780067 · Cited by 30
Kovaleva, O. V., Алексеевна, П. П., Sorokin, M., Mochalnikova, V. V., Kataev, V., Khlopko, Y. A., Plotnikov, A. O., Stilidi, I. S., Кушлинский, Н. Е., & Gratchev, A. N. (2022) · Biomedicines · doi:10.3390/biomedicines10071516 · Cited by 30
Saberzadeh-Ardestani, B., Foster, N. R., Lee, H. E., Shi, Q., Alberts, S. R., Smyrk, T. C., & Sinicrope, F. A. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.07.1942 · Cited by 31
The Impact of the Gut Microbiome on Colorectal Cancer
Maisonneuve, C., Irrazábal, T., Martín, A., Girardin, S. E., & Philpott, D. J. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050240 · Cited by 30
Characterization of Mucosal Dysbiosis of Early Colonic Neoplasia
Hong, B., Ideta, T., Lemos, B. S., Igarashi, Y., Tan, Y., DiSiena, M., Mo, A., Birk, J. W., Forouhar, F., Devers, T. J., et al. (2019) · npj Precision Oncology · doi:10.1038/s41698-019-0101-6 · Cited by 33
Impact of Fusobacterium nucleatum in the gastrointestinal tract on natural killer cells
Kim, Y. J., Kim, B. K., Park, S. J., & Kim, J. H. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i29.4879 · Cited by 31
Guevarra, L. A., Afable, A. C. F., Belza, P. J. O., Dy, K. J. S., Lee, S. J. Q., Sy-Ortin, T., & Albano, P. M. (2018) · Infectious Agents and Cancer · doi:10.1186/s13027-018-0184-7 · Cited by 29
Mohamed, A. A. A., al-Ramadi, B. K., & Fernández-Cabezudo, M. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031747 · Cited by 31
Huangfu, S., Zhang, W.-B., Zhang, H., Yang, L., Zhang, Y., Nie, J.-L., Chu, X., Chen, C.-S., Jiang, H., & Pan, J. (2021) · Journal of Cancer · doi:10.7150/jca.50111 · Cited by 29
Bostanghadiri, N., Razavi, S., Shariati, A., Talebi, M., Mirkalantari, S., Razavi, À. E., & Darban‐Sarokhalil, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1302719 · Cited by 27
Fusobacterium nucleatum modulates the Wnt/β-catenin pathway in colorectal cancer development
Mondal, T., Chattopadhyay, D., Mondal, P. S., Das, S., Mondal, A., Das, A., Samanta, S., & Saha, T. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140196 · Cited by 27
Nie, S., Wang, A., & Yuan, Y. (2020) · Journal of Cancer · doi:10.7150/jca.50918 · Cited by 28
Jiang, T., Yang, T., Chen, Y., Miao, Y., Xu, Y., Jiang, H., Yang, M., & Mao, C. (2022) · Theranostics · doi:10.7150/thno.70719 · Cited by 31
Negruț, R. L., Coțe, A., & Maghiar, A. M. (2023) · Microorganisms · doi:10.3390/microorganisms11061586 · Cited by 28
Colorectal Cancer at the Crossroads: The Good, the Bad, and the Future of Platinum-Based Drugs
Kee, J. X., Yau, J. N. N., Muthuramalingam, R. P. K., Wang, X., Chng, W. H., Lopez‐Sanchez, A., Tay, K. K. W., Deng, L., Gibson, D., Bertrand, H. C., et al. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.5c00041 · Cited by 29
Compositional Shift of Oral Microbiota Following Surgical Resection of Tongue Cancer
Kageyama, S., Nagao, Y., Ma, J., Asakawa, M., Yoshida, R., Takeshita, T., Hirosue, A., Yamashita, Y., & Nakayama, H. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.600884 · Cited by 25
Fusobacterium Nucleatum Is a Risk Factor for Metastatic Colorectal Cancer
Chen, W., Zhang, X., Zhang, Y.-P., Yue, C.-B., Wang, Y.-L., Pan, H., Zhang, Y., Liu, H., & Zhang, Y. (2022) · Current Medical Science · doi:10.1007/s11596-022-2597-1 · Cited by 26
Implication of gut microbes and its metabolites in colorectal cancer
Kumar, A., Ali, A., Kapardar, R. K., Dar, G. M., Nimisha, Apurva, A., Sharma, A. K., Verma, R., Sattar, R. S. A., Ahmad, E., et al. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04422-2 · Cited by 26
Xu, X., Zhang, M., Liu, X., Chai, M., Diao, L., Ma, L., Nie, S., Xu, M., Wang, Y., Mo, F., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107167 · Cited by 25
Șurlin, P., Nicolae, F. M., Şurlin, V., Pătrașcu, Ș., Ungureanu, B. S., Didilescu, A. C., & Gheonea, D. I. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123885 · Cited by 25
Wielandt, A. M., Hurtado, C., Mauricio Moreno, C., Villarroel, C., Castro, M., Estay, M., Simian, D., Martínez, M., Vial, M. T., Kronberg, U., et al. (2020) · Tumor Biology · doi:10.1177/1010428320938492 · Cited by 24
Microbe-Driven Genotoxicity in Gastrointestinal Carcinogenesis
Hartl, K., & Sigal, M. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207439 · Cited by 24
Zhou, B., Lu, J., Beck, J. D., MOSS, K. L., Prizment, A. E., Demmer, R. T., Rodriguez, K. A. P., Joshu, C. E., Michaud, D. S., & Platz, E. A. (2022) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-22-0601 · Cited by 24
Porto-Álvarez, J., Cernadas, E., Martínez, R. A., Fernández-Delgado, M., Huelga-Zapico, E., González‐Castro, V., Baleato‐González, S., García‐Figueiras, R., López, J. R. A., & Souto, M. (2023) · Biomedicines · doi:10.3390/biomedicines11082144 · Cited by 23
Ancient Thali Diet: Gut Microbiota, Immunity, and Health.
Shondelmyer, K., Knight, R. D., Sanivarapu, A., Ogino, S., & Vanamala, J. K. P. (2018) · Europe PMC (PubMed Central) · Cited by 23
Serrated neoplasia in the colorectum: gut microbiota and molecular pathways
Kang, X., Zhang, R., Kwong, T. N. Y., Lui, R. N.-S., Wu, W. K. K., Sung, J. J. �., Yu, J. Q., & Wong, S. H. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1863135 · Cited by 23
Rye, M. S., Garrett, K. L., Holt, R. A., Platell, C. F. E., & McCoy, M. J. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262416 · Cited by 24
Immunomodulation by Gut Microbiome on Gastrointestinal Cancers: Focusing on Colorectal Cancer
AL-Ishaq, R. K., Koklesová, L., Kubatka, P., & Büsselberg, D. (2022) · Cancers · doi:10.3390/cancers14092140 · Cited by 23
Zhang, X., Wang, Y., Fan, R., Zhang, L., Li, Z., Zhang, Y., Zheng, W., Wang, L., Liu, B., & Quan, C. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00394-23 · Cited by 23
Ma, C., Gao, Q., Zhang, W., Zhu, Q., Tang, W., Blachier, F., Ding, H., & Kong, X. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.575685 · Cited by 22
From the Colon to the Liver: How Gut Microbiota May Influence Colorectal Cancer Metastatic Potential
Mignini, I., Piccirilli, G., Galasso, L., Termite, F., Esposto, G., Ainora, M. E., Gasbarrini, A., & Zocco, M. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020420 · Cited by 25
Mann, S., Sidhu, M., & Gowin, K. L. (2020) · Nutrients · doi:10.3390/nu12082226 · Cited by 21
Deng, X., & Huang, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1651837 · Cited by 21
Noguti, J., Chan, A. A., Bandera, B. C., Brislawn, C., Protić, M., Sim, M., Jansson, J. K., Bilchik, A. J., & Lee, D. J. (2018) · Oncotarget · doi:10.18632/oncotarget.25276 · Cited by 21
Fusobacterium�nucleatum‑positive colorectal cancer (Review)
Yang, Z., & Ji, G. (2019) · Oncology Letters · doi:10.3892/ol.2019.10433 · Cited by 20
The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence
King, M., Hurley, H., Davidson, K. R., Dempsey, E. C., Barron, M. A., Chan, E. D., & Frey, A. (2020) · Immune Network · doi:10.4110/in.2020.20.e30 · Cited by 21
Microbiota-Derived Natural Products Targeting Cancer Stem Cells: Inside the Gut Pharma Factory
Artusa, V., Calabrone, L., Mortara, L., Peri, F., & Bruno, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054997 · Cited by 22
The microbiota and renal cell carcinoma
Wu, K., Li, Y., Ma, K., Zhao, W., Yao, Z., Zheng, Z., Sun, F., Mu, X., Liu, Z., & Zheng, J. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00876-9 · Cited by 22
Data mining analysis of human gut microbiota links Fusobacterium spp. with colorectal cancer onset
Kharrat, N., Assidi, M., Abu-Elmagd, M. M., Pushparaj, P. N., Alkhaldy, A. A., Arfaoui, L., Naseer, M. I., Omri, A. E., Messaoudi, S. A., Buhmeida, A. S., et al. (2019) · Bioinformation · doi:10.6026/97320630015372 · Cited by 23
Nakayama, Y., Iijima, T., Inokuchi, T., Kojika, E., Takao, M., Takao, A., Koizumi, K., Horiguchi, S., Hishima, T., & Yamaguchi, T. (2021) · International Journal of Clinical Oncology · doi:10.1007/s10147-021-01968-y · Cited by 20
Jensen, T. S. R., Mahmood, B., Damm, M. M. B., Backe, M. B., Dahllöf, M. S., Poulsen, S. S., Hansen, M. B., & Bindslev, N. (2018) · BMC Gastroenterology · doi:10.1186/s12876-018-0759-1 · Cited by 20
Liu, Y. C. G., Lan, S., Hirano, H., Lin, L.-M., Hori, K., Lin, C., Zwetchkenbaum, S. R., Minakuchi, S., & Teng, A. Y. (2020) · Journal of Dental Sciences · doi:10.1016/j.jds.2020.09.007 · Cited by 20
Probiotics Exert Gut Immunomodulatory Effects by Regulating the Expression of Host miRNAs
Li, W., Zeng, Y., Zhong, J., Hu, Y., Xiong, X., Zhou, Y., & Li, F. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10443-9 · Cited by 21
Gut microbiota in cancer initiation, development and therapy
Zhang, R., Zhang, X., Lau, H. C.-H., & Yu, J. Q. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2831-x · Cited by 19
Role and potential clinical utility of ARID1A in gastrointestinal malignancy
Wang, R., Chen, M., Ye, X., & Poon, K. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108360 · Cited by 20
Lu, Q., Niu, J., Wu, Y., & Zhang, W. (2022) · Livestock Science · doi:10.1016/j.livsci.2022.104875 · Cited by 20
Immuno-oncology-microbiome axis of gastrointestinal malignancy
Lin, Q., Guan, S.-W., & Yu, H. (2023) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v15.i5.757 · Cited by 20
The next bastion to be conquered in immunotherapy: microsatellite stable colorectal cancer
Ding, K., Mou, P., Wang, Z., Liu, S., Liu, J., Lü, H., & Yu, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1298524 · Cited by 19
Vigneswaran, J., & Shogan, B. D. (2020) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-020-04694-4 · Cited by 20
Association of Fusobacterium nucleatum infection and colorectal cancer: A Mexican study
Cuellar‐Gomez, H., Ocharan-Hernández, M. E., Calzada‐Mendoza, C. C., & Comoto-Santacruz, D. A. (2021) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2021.07.001 · Cited by 22
Phipps, A. I., Hill, C. M., Lin, G. I., Malen, R. C., Reedy, A. M., Kahsai, O. J., Ammar, H., Curtis, K. R., Ma, N., Randolph, T. W., et al. (2025) · Gastro Hep Advances · doi:10.1016/j.gastha.2025.100644 · Cited by 19
Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
Ibragimova, S., Ramachandran, R., Ali, F. R., Lipovich, L., & Ho, S. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725821 · Cited by 18
Sambruni, G., Macandog, A. D. G., Wirbel, J., Cagnina, D., Catozzi, C., Dallavilla, T., Borgo, F., Fazio, N., Romario, U. F., Petz, W. L., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01180-9 · Cited by 19
Shimomura, Y., Sugi, Y., Kume, A., Tanaka, W., Yoshihara, T., Matsuura, T., Komiya, Y., Ogata, Y., Suda, W., Hattori, M., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.05123-22 · Cited by 16
Luo, M. (2024) · American Journal of Cancer Research · doi:10.62347/myza2640 · Cited by 19
Role of bioactive lipofishins in prevention of inflammation and colon cancer
Lombardi, V., Carrera, I., Corzo, L., & Cacabelos, R. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.012 · Cited by 18
Arabfard, M., Ohadi, M., Tabar, V. R., Delbari, A., & Kavousi, K. (2019) · BMC Genomics · doi:10.1186/s12864-019-6140-0 · Cited by 18
Comparison of the fecal microbiomes of healthy and diarrheic captive wild boar
Bi, W., Deng, B., Yong, F., Zhou, H., Qu, C., & Zhou, Z. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104377 · Cited by 18
Villar-Ortega, P., Ruíz, M. E., Gutiérrez-Soto, M., Jiménez, M. R.-C., Navarro‐Marí, J. M., & Fernández, J. G. (2022) · Enfermedades infecciosas y microbiologia clinica (English ed ) · doi:10.1016/j.eimce.2022.02.007 · Cited by 17
Relationship Between Intestinal Microorganisms and T Lymphocytes In Colorectal Cancer
Han, S., Xi, Y., Quan, Q., Pan, Y., Da, M., & Zhou, Q. (2019) · Future Oncology · doi:10.2217/fon-2018-0595 · Cited by 16
Seesaha, P. K., Chen, X., Wu, X., Xu, H., Li, C., Jheengut, Y., Zhao, F., Liu, L., & Zhang, D. (2020) · Future Oncology · doi:10.2217/fon-2019-0552 · Cited by 20
Pluske, J. R., Turpin, D. L., Sahibzada, S., Pineda, L., Han, Y., & Collins, A. M. (2021) · Translational Animal Science · doi:10.1093/tas/txab212 · Cited by 15
Metadata
- Authors
- Nosho, K.
- Affiliations
- Sapporo Medical University (JP)
- Corresponding author
- Nosho, Katsuhiko
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2016
- Volume
- 22
- Issue
- 2
- Pages
- 557
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4716059
- OpenAlex
- W2298181742
- Cited by
- 344
- References
- 99
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 34 · 2023: 47 · 2022: 49 · 2021: 46 · 2020: 36 · 2019: 33 · 2018: 36 · 2017: 17 · 2016: 8
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pancreas Research Foundation of Japan
- Japan Society for the Promotion of Science (221S0001, 25670371, 26640101)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- Fusobacterium nucleatum, colorectal cancer, gut microbiota, microsatellite instability, antitumor immunity, T cell infiltration, immunosuppression, myeloid-derived cells, miR-21, IL-10, prostaglandin E2, dendritic cells, Japanese patients
- MeSH terms
- Gastrointestinal Microbiome, Animals, Fusobacterium Infections, Humans, Immunity, Innate, Lymphocyte Activation, Biomarkers, Tumor, Colorectal Neoplasms, T-Lymphocyte Subsets, Lymphocytes, Tumor-Infiltrating, Fusobacterium nucleatum, Tumor Escape, Microsatellite Instability, Host-Pathogen Interactions, Adaptive Immunity, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review