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Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer
Open accessAbstract
The human intestinal microbiome plays a major role in human health and diseases, including colorectal cancer. Colorectal carcinogenesis represents a heterogeneous process with a differing set of somatic molecular alterations, influenced by diet, environmental and microbial exposures, and host immunity. Fusobacterium species are part of the human oral and intestinal microbiota. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue. Using 511 colorectal carcinomas from Japanese patients, we assessed the presence of F. nucleatum. Our results showed that the frequency of F. nucleatum positivity in the Japanese colorectal cancer was 8.6% (44/511), which was lower than that in United States cohort studies (13%). Similar to the United States studies, F. nucleatum positivity in Japanese colorectal cancers was significantly associated with microsatellite instability (MSI)-high status. Regarding the immune response in colorectal cancer, high levels of infiltrating T-cell subsets (i.e., CD3+, CD8+, CD45RO+, and FOXP3+ cells) have been associated with better patient prognosis. There is also evidence to indicate that molecular features of colorectal cancer, especially MSI, influence T-cell-mediated adaptive immunity. Concerning the association between the gut microbiome and immunity, F. nucleatum has been shown to expand myeloid-derived immune cells, which inhibit T-cell proliferation and induce T-cell apoptosis in colorectal cancer. This finding indicates that F. nucleatum possesses immunosuppressive activities by inhibiting human T-cell responses. Certain microRNAs are induced during the macrophage inflammatory response and have the ability to regulate host-cell responses to pathogens. MicroRNA-21 increases the levels of IL-10 and prostaglandin E2, which suppress antitumor T-cell-mediated adaptive immunity through the inhibition of the antigen-presenting capacities of dendritic cells and T-cell proliferation in colorectal cancer cells. Thus, emerging evidence may provide insights for strategies to target microbiota, immune cells and tumor molecular alterations for colorectal cancer prevention and treatment. Further investigation is needed to clarify the association of Fusobacterium with T-cells and microRNA expressions in colorectal cancer.
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“supporting studies reporting that F nucleatum reduces the anti-tumor immune response.”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [29]
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“Moreover, levels of F nucleatum in tumor tissue have been associated with lower infiltration by T cells,29, 30”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [29]
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PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,320
The blockade of immune checkpoints in cancer immunotherapy
Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838
PD-1 blockade induces responses by inhibiting adaptive immune resistance
Tumeh, P. C., Harview, C. L., Yearley, J. H., Shintaku, I. P., Taylor, E. J. M., Robert, L., Chmielowski, B., Spasic, M., Henry, G., Ciobanu, V., et al. (2014) · Nature · doi:10.1038/nature13954 · Cited by 6,609
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
Herbst, R. S., Soria, J.-C., Kowanetz, M., Fine, G. D., Hamid, O., Gordon, M. S., Sosman, J. A., McDermott, D. F., Powderly, J. D., Gettinger, S. N., et al. (2014) · Nature · doi:10.1038/nature14011 · Cited by 5,231
The immune contexture in human tumours: impact on clinical outcome
Fridman, W. H., Pagès, F., Sautès-Fridman, C., & Galon, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3245 · Cited by 4,981
Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
Snyder, A., Makarov, V., Merghoub, T., Yuan, J., Zaretsky, J. M., Desrichard, A., Walsh, L. A., Postow, M. A., Wong, P., Ho, T. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1406498 · Cited by 4,286
Nivolumab plus Ipilimumab in Advanced Melanoma
Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230
Molecular and genetic properties of tumors associated with local immune cytolytic activity
Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G., & Hacohen, N. (2015) · Cell · doi:10.1016/j.cell.2014.12.033 · Cited by 3,825
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Mármol, I., Sánchez‐de‐Diego, C., Pradilla-Dieste, A., Cerrada, E., & Yoldi, M. R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010197 · Cited by 1,639
Diet, microorganisms and their metabolites, and colon cancer
O'Keefe, S. J. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.165 · Cited by 1,100
Yang, Y. P., Weng, W., Peng, J., Hong, L., Yang, L., Toiyama, Y., Gao, R., Liu, M., Yin, M., Pan, C., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.11.018 · Cited by 1,037
The Intestinal Microbiota in Colorectal Cancer.
Tilg, H., Adolph, T. E., Gerner, R. R., & Moschen, A. R. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.004 · Cited by 777
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752
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Thanikachalam, K., & Khan, G. N. (2019) · Nutrients · doi:10.3390/nu11010164 · Cited by 782
Intestinal flora and disease mutually shape the regional immune system in the intestinal tract
Zhou, B., Yuan, Y., Zhang, S., Guo, C., Li, X., Li, G., Xiong, W., & Zeng, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00575 · Cited by 396
Casasanta, M. A., Yoo, C. C., Udayasuryan, B., Sanders, B. E., Umaña, A., Zhang, Y., Peng, H., Duncan, A. J., Wang, Y., Li, L., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aba9157 · Cited by 335
Mehta, R. S., Nishihara, R., Cao, Y., Song, M., Mima, K., Qian, Z. R., Nowak, J. A., Kosumi, K., Hamada, T., Masugi, Y., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.6374 · Cited by 325
The oral–gut microbiome axis in health and disease
Kunath, B. J., Rudder, C. D., Laczny, C. C., Letellier, E., & Wilmes, P. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01075-5 · Cited by 372
Gut Microbiota in Cancer Immune Response and Immunotherapy
Zhou, C., Zhou, Y., & Fang, J. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.01.010 · Cited by 313
Xu, C., Fan, L., Lin, Y., Shen, W., Qi, Y., Zhang, Y., Chen, Z., Wang, L., Long, Y., Hou, T., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1980347 · Cited by 294
Zhang, X., Dou, Y., Wu, D., Gao, X., Shao, F., Zhao, M., Wang, J., Ma, J., Wang, W., Qin, X., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.01.013 · Cited by 290
Fusobacterium nucleatum in colorectal carcinoma tissue according to tumor location
Mima, K., Cao, Y., Chan, A. T., Qian, Z. R., Nowak, J. A., Masugi, Y., Shi, Y., Song, M., da Silva, A., Gu, M., et al. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.53 · Cited by 284
Hsieh, Y.-Y., Tung, S.-Y., Pan, H.-Y., Yen, C.-W., Xu, H.-W., Lin, Y.-J., Deng, Y.-F., Hsu, W.-T., Wu, C.-S., & Li, C. (2018) · Scientific Reports · doi:10.1038/s41598-017-18596-0 · Cited by 269
Fusobacterium nucleatum and colorectal cancer: A review
Shang, F.-M., & Liu, H.-L. (2018) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v10.i3.71 · Cited by 258
Ogino, S., Nowak, J. A., Hamada, T., Milner, D. A., & Nishihara, R. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012818 · Cited by 257
Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?
Ternes, D., Karta, J., Tsenkova, M., Wilmes, P., Haan, S., & Letellier, E. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.01.001 · Cited by 267
Hamada, T., Zhang, X., Mima, K., Bullman, S., Sukawa, Y., Nowak, J. A., Kosumi, K., Masugi, Y., Twombly, T. S., Cao, Y., et al. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0174 · Cited by 237
Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer
Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-11237-6 · Cited by 227
“to have an association with immune response in the development of CRC[44].”
BackgroundHallmarks of cancer—the new testament
Senga, S. S., & Grose, R. P. (2021) · Open Biology · doi:10.1098/rsob.200358 · Cited by 245
Hanus, M., Parada‐Venegas, D., Landskron, G., Wielandt, A. M., Hurtado, C., Álvarez, K., Hermoso, M. A., López-Köstner, F., & la Fuente, M. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.612826 · Cited by 208
Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy
Wang, G., Yu, Y., Wang, Y., Wang, J., Guan, R., Sun, Y., Shi, F., Gao, J., & Fu, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28436 · Cited by 200
Fusobacterium nucleatum and cancer
Alon‐Maimon, T., Mandelboim, O., & Bachrach, G. (2022) · Periodontology 2000 · doi:10.1111/prd.12426 · Cited by 203
Bourgeois, D. M., Inquimbert, C., Ottolenghi, L., & Carrouel, F. (2019) · Microorganisms · doi:10.3390/microorganisms7100424 · Cited by 199
Microbial dysbiosis in the gut drives systemic autoimmune diseases
Mousa, W. K., Chehadeh, F., & Husband, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.906258 · Cited by 216
The oral microbiota – a mechanistic role for systemic diseases
Jia, G., Zhi, A., Lai, P. F. H., Wang, G., Xia, Y., Xiong, Z., Zhang, H., Che, N., & Ai, L. (2018) · BDJ · doi:10.1038/sj.bdj.2018.217 · Cited by 192
Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine
Ogino, S., Nowak, J. A., Hamada, T., Phipps, A. I., Peters, U., Milner, D. A., Giovannucci, E. L., Nishihara, R., Giannakis, M., Garrett, W. S., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315537 · Cited by 170
Fan, Z., Tang, P., Li, C., Yang, Q., Xu, Y., Su, C., & Li, L. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2022.2145729 · Cited by 150
Gut Microbiota, Fusobacteria, and Colorectal Cancer
Kelly, D., Yang, L., & Pei, Z. (2018) · Diseases · doi:10.3390/diseases6040109 · Cited by 152
Amitay, E. L., Werner, S., Vital, M., Pieper, D. H., Höfler, D., Gierse, I.-J., Butt, J., Balavarca, Y., Ćuk, K., & Brenner, H. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx053 · Cited by 141
Exploring the Role of Gut Microbiome in Colon Cancer
Chattopadhyay, I., Dhar, R., Pethusamy, K., Seethy, A. A., Srivastava, T. P., Sah, R., Sharma, J. N., & Karmakar, S. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03498-9 · Cited by 147
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Zhou, Z., Chen, J., Yao, H., & Hu, H. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00371 · Cited by 140
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Yang, Q., Huang, X., Zhao, S., Sun, W., Yan, Z., Wang, P., Li, S., Huang, W., Zhang, S., Liu, L., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00502 · Cited by 138
Neuzillet, C., Marchais, M., Vacher, S., Hilmi, M., Schnitzler, A., Meseure, D., Leclère, R., Lecerf, C., Dubot, C., Jeannot, E., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-86816-9 · Cited by 128
Stress and cancer: The mechanisms of immune dysregulation and management
Liu, Y.-X., Tian, S., Ning, B., Huang, T., Li, Y., & Wei, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1032294 · Cited by 137
Liu, L., Tabung, F. K., Zhang, X., Nowak, J. A., Qian, Z. R., Hamada, T., Nevo, D., Bullman, S., Mima, K., Kosumi, K., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.04.030 · Cited by 118
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Temraz, S. N., Nassar, F. J., Nasr, R., Charafeddine, M., Mukherji, D., & Shamseddine, A. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174155 · Cited by 125
Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice
Mendes, M. C. S., Paulino, D. S., Brambilla, S. R., Camargo, J. A., Persinoti, G. F., & Carvalheira, J. B. C. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i18.1995 · Cited by 116
Rajpoot, M., Sharma, A. K., Sharma, A. K., & Gupta, G. K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.02.003 · Cited by 119
Gomes, S., Oliveira, C. S., Azevedo‐Silva, J., Casanova, M. R., Barreto, J., Pereira, H., Chaves, S. R., Rodrigues, L. R., Casal, M., Côrte‐Real, M., et al. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180530102050 · Cited by 116
Yang, Y., Chen, G., Yang, Q., Ye, J., Cai, X., Tsering, P., Cheng, X., Hu, C., Zhang, S., & Cao, P. (2017) · Oncotarget · doi:10.18632/oncotarget.16458 · Cited by 110
The colorectal cancer immune microenvironment and approach to immunotherapies
Koi, M., & Carethers, J. M. (2017) · Future Oncology · doi:10.2217/fon-2017-0145 · Cited by 113
Proença, M. A., Biselli, J. M., Succi, M., Severino, F. E., Berardinelli, G. N., Caetano, A., Reis, R. M., Hughes, D. J., & Silva, A. E. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i47.5351 · Cited by 113
Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer
Wang, S.-T., Cui, W., Pan, D., Jiang, M., Chang, B., & Sang, L.-X. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i6.562 · Cited by 112
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Bars, P. L., Matamoros, S., Montassier, E., Vacon, F. L., Potel, G., Soueidan, A., Jordana, F., & de la Cochetière, M.-F. (2017) · Canadian Journal of Microbiology · doi:10.1139/cjm-2016-0603 · Cited by 111
Borowsky, J., Haruki, K., Lau, M. C., Costa, A. D., Väyrynen, J. P., Ugai, T., Arima, K., da Silva, A., Felt, K. D., Zhao, M. M., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4009 · Cited by 110
Wang, H., Li, L., Guo, S., Zeng, Q., Ning, F., Liu, W., & Zhang, G. (2016) · Scientific Reports · doi:10.1038/srep33440 · Cited by 105
Li, Y., Xing, S., Chen, F., Li, Q., Dou, S., Huang, Y., An, J., Liu, W., & Zhang, G. (2023) · Nature Communications · doi:10.1038/s41467-023-40987-3 · Cited by 102
Hamada, T., Nowak, J. A., Milner, D. A., Song, M., & Ogino, S. (2019) · The Journal of Pathology · doi:10.1002/path.5236 · Cited by 100
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Kaur, H., Das, C., & Mande, S. S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02166 · Cited by 99
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Li, Y., Hu, X., Yang, S., Zhou, J., Qi, L., Sun, X., Fan, M., Xu, S., Cha, M., Zhang, M., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00300 · Cited by 97
Gut microbiome associated with APC gene mutation in patients with intestinal adenomatous polyps
Liang, S., Mao, Y. K., Liao, M., Xu, Y., Chen, Y.-C., Huang, X., Wei, C., Wu, C., Wang, Q., Pan, X., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37399 · Cited by 97
Lee, D., Han, S., Kang, J., Bae, J. M., Kim, H., Won, J., Jeong, S., Park, K. J., Kang, G. H., & Kim, T. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6681-5 · Cited by 95
Ranjbar, M., Salehi, R., Javanmard, S. H., Rafiee, L., Faraji, H., jafarpor, S., Ferns, G. A., Ghayour‐Mobarhan, M., Manian, M., & Nedaeinia, R. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01886-z · Cited by 101
Li, J., Zhang, A., Wu, F., & Wang, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.841552 · Cited by 99
Morgillo, F., Dallio, M., Corte, C. M. D., Gravina, A. G., Viscardi, G., Loguercio, C., Ciardiello, F., & Federico, A. (2018) · Neoplasia · doi:10.1016/j.neo.2018.05.002 · Cited by 99
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Kageyama, S., Takeshita, T., Takeuchi, K., Asakawa, M., Matsumi, R., Furuta, M., Shibata, Y., Nagai, K., Ikebe, M., Morita, M., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01780 · Cited by 96
Yang, Q., Huang, X., Wang, P., Yan, Z., Sun, W., Zhao, S., & Gun, S. (2019) · MicrobiologyOpen · doi:10.1002/mbo3.923 · Cited by 88
Sakamoto, Y., Mima, K., Ishimoto, T., Ogata, Y., Imai, K., Miyamoto, Y., Akiyama, T., Daitoku, N., Hiyoshi, Y., Iwatsuki, M., et al. (2021) · Cancer Science · doi:10.1111/cas.15126 · Cited by 85
Role of oral and gut microbiome in nitric oxide-mediated colon motility
Walker, M., Pratap, S., Southerland, J. H., Farmer‐Dixon, C. M., Kesavalu, L. N., & Gangula, P. R. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.06.003 · Cited by 81
Bi, K., Zhang, X., Chen, W., & Diao, H. (2020) · Genes · doi:10.3390/genes11091075 · Cited by 84
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Huybrechts, I., Zouiouich, S., Loobuyck, A., Vandenbulcke, Z., Vogtmann, E., Pisanu, S., Iguacel, I., Scalbert, A., Indave, I., Smelov, V., et al. (2020) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0288 · Cited by 80
Yamamoto, H., & Imai, K. (2019) · Seminars in Oncology · doi:10.1053/j.seminoncol.2019.08.003 · Cited by 75
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Hussan, H., Clinton, S. K., Roberts, K., & Bailey, M. T. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i48.8626 · Cited by 76
Koi, M., Okita, Y., & Carethers, J. M. (2018) · Journal of the Anus Rectum and Colon · doi:10.23922/jarc.2017-055 · Cited by 78
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Zhang, S., Cai, S., & Ma, Y. (2018) · Journal of Cancer · doi:10.7150/jca.24048 · Cited by 77
Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance
Ye, C., Liu, X., Liu, Z., Pan, C., Zhang, X., Zhao, Z., & Sun, H. (2024) · Cancer Biology & Therapy · doi:10.1080/15384047.2024.2306676 · Cited by 76
Analysis of oral microbiota in Japanese oral cancer patients using 16S rRNA sequencing
Takahashi, Y., Park, J., Hosomi, K., Yamada, T., Kobayashi, A., Yamaguchi, Y., Iketani, S., Kunisawa, J., Mizuguchi, K., Maeda, N., et al. (2019) · Journal of Oral Biosciences · doi:10.1016/j.job.2019.03.003 · Cited by 70
Li, G., Sun, Y., Huang, Y., Lian, J., Wu, S., Luo, D., & Gong, H. (2023) · BMC Cancer · doi:10.1186/s12885-023-10844-z · Cited by 69
Osman, M. A., Neoh, H., Mutalib, N. A., Chin, S., & Jamal, R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00767 · Cited by 71
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Ding, C., Tang, W., Fan, X., & Wu, G. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s170626 · Cited by 68
Randrian, V., Evrard, C., & Tougeron, D. (2021) · Cancers · doi:10.3390/cancers13123063 · Cited by 65
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Inamura, K. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.06.006 · Cited by 63
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Yu, D., Liu, X., Han, G., Liu, Y., Zhao, X., Wang, D., Bian, X., Gu, T., & Wen, L. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0490-8 · Cited by 61
de Carvalho, A. C., Pereira, L. D. M., Datorre, J. G., dos Santos, W., Berardinelli, G. N., Matsushita, M., de Oliveira, M. A., Durães, R. O., Guimarães, D. P., & Reis, R. M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00813 · Cited by 64
Lee, J. A., Yoo, S.-Y., Oh, H. J., Jeong, S., Cho, N.-Y., Kang, G. H., & Kim, J. H. (2021) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-020-02657-x · Cited by 61
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Uchino, Y., Goto, Y., Konishi, Y., Tanabe, K., Toda, H., Wada, M., Kita, Y., Beppu, M., Mori, S., Hijioka, H., et al. (2021) · Cancers · doi:10.3390/cancers13133332 · Cited by 58
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Tunsjø, H. S., Gundersen, G., Rangnes, F., Noone, J. C., Endres, A., & Bemanian, V. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03562-7 · Cited by 58
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Tsuchiya, Y., Loza, E., Villa‐Gomez, G., Trujillo, C. C., Báez, S., Asai, T., Ikoma, T., Endoh, K., & Nakamura, K. (2018) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2018.19.4.961 · Cited by 54
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Younginger, B. S., Mayba, O., Reeder, J., Nagarkar, D. R., Modrusan, Z. D., Albert, M. L., & Byrd, A. L. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.100920 · Cited by 48
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Metadata
- Authors
- Nosho, K.
- Affiliations
- Sapporo Medical University (JP)
- Corresponding author
- Nosho, Katsuhiko
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2016
- Volume
- 22
- Issue
- 2
- Pages
- 557
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4716059
- OpenAlex
- W2298181742
- Cited by
- 344
- References
- 99
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 34 · 2023: 47 · 2022: 49 · 2021: 46 · 2020: 36 · 2019: 33 · 2018: 36 · 2017: 17 · 2016: 8
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pancreas Research Foundation of Japan
- Japan Society for the Promotion of Science (221S0001, 25670371, 26640101)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- Fusobacterium nucleatum, colorectal cancer, gut microbiota, microsatellite instability, antitumor immunity, T cell infiltration, immunosuppression, myeloid-derived cells, miR-21, IL-10, prostaglandin E2, dendritic cells, Japanese patients
- MeSH terms
- Gastrointestinal Microbiome, Animals, Fusobacterium Infections, Humans, Immunity, Innate, Lymphocyte Activation, Biomarkers, Tumor, Colorectal Neoplasms, T-Lymphocyte Subsets, Lymphocytes, Tumor-Infiltrating, Fusobacterium nucleatum, Tumor Escape, Microsatellite Instability, Host-Pathogen Interactions, Adaptive Immunity, Tumor Microenvironment
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