Irritable bowel syndrome symptom severity improves equally with probiotic and placebo
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AIM: NCFM on irritable bowel syndrome (IBS) symptoms and quality of life (QoL). METHODS: colony-forming units of NCFM or placebo daily for 12 wk. IBS Symptom Severity Score (IBS-SSS), which constituted the primary outcome, and secondary outcomes, including individual IBS symptoms, IBS-related QoL questionnaire, anxiety and depression, defecation frequency, and stool consistency, were assessed at baseline at the end of the 8-wk run-in period, after 4 and 12 wk of intervention, and after a 4-wk washout. RESULTS: combined active doses = 0.0460). CONCLUSION: NCFM alleviates moderate to severe abdominal pain, consistent with earlier observations of this strain mitigating visceral pain through increased analgesic receptor expression.
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Probiotics are beneficial in improving overall symptoms in patients with IBS, but there are contradictory reports on improvements in specific symptoms.
“Based on the international consensus and existing evidence, probiotics are beneficial in improving overall symptoms in patients with IBS [29,30,31,32,33,34,35], but there are still contradictory reports on improvements in specific symptoms [36,37,38].”
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Probiotic therapy in patients with irritable bowel syndrome: does it have a real role?
Montasser, I. F., ElGindy, E. M., Abdel-Samie, O. A. M., & Aly, H. I. S. (2021) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-021-00051-2 · Cited by 6 · see citing works
Why Use Nutraceutical Strategies for the Irritable Bowel Syndrome?
di Michele, F. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210917115255 · Cited by 5 · see citing works
The Gut Microbiome May Help Address Mental Health Disparities in Hispanics: A Narrative Review
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Probiotics and prebiotics, including fibers and medicinal foods
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A Microbial Relationship Between Irritable Bowel Syndrome and Depressive Symptoms
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Modern aspects of the management of patients with irritable bowel syndrome
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Functional semi-finished fish product evaluation: organoleptic and evidence in vivo
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Probiotics for gastrointestinal health and disease treatment
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Synergism of components as the main approach to creation of a probiotic complex
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Probióticos na redução de sintomas de ansiedade e depressão: uma revisão integrativa
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Probiotics: present and future
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Nutritional Therapies for Irritable Bowel Syndrome: a Focus on Prebiotics and Probiotics
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Therapeutics perspectives of incredible probiotics
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Wie wirksam sind Probiotika bei Reizdarm, CED und C.-difficile-Infektionen?
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- Authors
- Lyra, A., Hillilä, M., Huttunen, T., Männikkö, S., Taalikka, M., Tennilä, J., Tarpila, A., Lahtinen, S., Ouwehand, A. C., & Veijola, L.
- Affiliations
- DuPont (Finland) (FI)
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2016
- Volume
- 22
- Issue
- 48
- Pages
- 10631
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC5192275
- OpenAlex
- W2560913755
- Cited by
- 106
- References
- 35
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 16 · 2022: 15 · 2021: 17 · 2020: 14 · 2019: 8 · 2018: 10 · 2017: 1 · 2016: 1
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, probiotics, placebo, symptom severity, quality of life, abdominal pain, anxiety, depression, stool frequency, stool consistency, visceral pain
- MeSH terms
- Adult, Colon, Dose-Response Relationship, Drug, Female, Humans, Intestinal Mucosa, Lactobacillus acidophilus, Male, Middle Aged, Pain Measurement, Surveys and Questionnaires, Receptors, Opioid, Severity of Illness Index, Abdominal Pain, Treatment Outcome, Probiotics, Irritable Bowel Syndrome, Visceral Pain
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