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Conjunctive representations, the hippocampus, and contextual fear conditioning

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RUDY, J. W., O'REILLY, R. C.·2001·Cognitive, Affective, & Behavioral Neuroscience

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Abstract

The context in which events occur can be represented as both (1) a set of independent features, the feature representation view, and (2) a set of features bound into a unitary representation, the conjunction representation view. It is assumed that extrahippocampal (e.g., neocortical) areas provide a basis for feature representations, but the hippocampal formation makes an essential contribution to the automatic storage of conjunctive representations. We develop this dual-representation view and explore its implications for hippocampal contributions to contextual fear conditioning processes. To this end, we discuss how our framework can resolve some of the conflicts in the recent literature relating the hippocampus to contextual fear conditioning. We also present new data supporting the role of a key mechanism afforded by conjunctive representations--pattern completion (the ability of a subset of a memory pattern to activate the complete memory)--in contextual fear conditioning. As is implied by this mechanism, we report that fear can be conditioned to the memory representation of a context that is not actually present at the time of shock. Moreover, this result is predicted by our computational model of cortical and hippocampal function. We suggest that pattern completion demonstrated in animals and by our model provides a mechanistic bridge to human declarative memory.

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(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
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Rescorla, R. A. (1972) · Medical Entomology and Zoology · Cited by 7,268
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Simple memory: a theory for archicortex
Marr, D. (1971) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1971.0078 · Cited by 2,771
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Hippocampal synaptic enhancement and information storage within a distributed memory system
McNaughton, B. L., & Morris, R. G. M. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90011-7 · Cited by 1,304
A model for stimulus generalization in Pavlovian conditioning.
Pearce, J. M. (1987) · Psychological Review · doi:10.1037/0033-295x.94.1.61 · Cited by 1,071
Configural association theory: The role of the hippocampal formation in learning, memory, and amnesia
Sutherland, R. J., & Rudy, J. W. (1989) · Psychobiology · doi:10.3758/bf03337828 · Cited by 970
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Self-citation
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Authors: RUDY, J. W., & O'REILLY, R. C.
Affiliations: University of Colorado Boulder (US)
Corresponding author: RUDY, J. W.
ORCID: RUDY, J. W.
Venue: Cognitive, Affective, & Behavioral Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2001-03-01
Volume: 1
Issue: 1
Pages: 66-82
ISSN: 1530-7026 (ISSN-L)
1531-135X
DOI: 10.3758/cabn.1.1.66
OpenAlex: W2165303994
Cited by: 247
References: 75
Citations by year: 2026: 5 · 2025: 4 · 2024: 10 · 2023: 2 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 15 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 14
FWCI: 5.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cognitive Affective & Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH061316, R01 MH61316-01)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: conjunctive representations, feature representation, hippocampus, contextual fear conditioning, pattern completion, hippocampal formation, memory storage, computational model of memory, declarative memory, contextual fear
MeSH terms: Animals, Arousal, Association Learning, Attention, Conditioning, Classical, Hippocampus, Mental Recall, Social Environment, Long-Term Potentiation, Rats

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Conjunctive representations, the hippocampus, and contextual fear conditioning

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