The Neurobiology of Conditioned and Unconditioned Fear: A Neurobehavioral System Analysis of the Amygdala
Abstract
A neurobehavioral system approach to conditioned and unconditioned fear is presented. By employing reproducible fear behaviors in Pavlovian conditioning and unconditioned fear paradigms, it has been possible to delineate some differences in neural circuitry and cellular biology for conditioned and unconditioned fear. It is suggested that the basolateral complex of the amygdala and the central nucleus of the amygdala are part of the neural circuitry for fear conditioning but not for unconditioned fear to a predator odor. Furthermore, changes in expression of the transcription factor early growth response gene 1 in the lateral nucleus of the amygdala are shown to be important for contextual fear conditioning but not for unconditioned fear to a predator odor. In addition, data suggest that although conditioning to a synthetic predator odor, trimethylthiazoline, has been difficult to demonstrate, conditioning can occur by modifying by the environment. Finally, the relevance of the animal studies to human anxiety disorders is discussed.
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Freezing is a universal fear response, observed both in reaction to conditioned or unconditioned stimuli or situations.
“Freezing is a universal fear response, observed both in reaction to conditioned (learned) or unconditioned (acutely threatening) stimuli or situations [22].”
From Freeze for action: neurobiological mechanisms in animal and human freezing (2017) · cites this paper as [22]
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · see citing works
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745 · see citing works
Preliminary analysis of functions of the temporal lobes in monkeys
KLÜVER, H. (1939) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1939.02270240017001 · Cited by 1,696 · see citing works
Pavlovian conditioning: it's not what you think it is
Rescorla, R. A. (1988) · American Psychologist · doi:10.1037/0003-066x.43.3.151 · Cited by 1,542 · see citing works
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536 · see citing works
Seligman, M. (1971) · Behavior Therapy · doi:10.1016/s0005-7894(71)80064-3 · Cited by 1,435 · see citing works
Ricardo, J. A., & Koh, E. T. (1978) · Brain Research · doi:10.1016/0006-8993(78)91125-3 · Cited by 1,362 · see citing works
Herdegen, T., & Leah, J. D. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00018-6 · Cited by 1,352 · see citing works
Swanson, L. W., & Petrovich, G. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01265-x · Cited by 1,351 · see citing works
Neuroimaging studies of mood disorders
Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,313 · see citing works
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310 · see citing works
Cortical pathways to the mammalian amygdala
McDonald, A. J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00003-3 · Cited by 1,303 · see citing works
Squire, L. R. (1986) · Science · doi:10.1126/science.3086978 · Cited by 1,278 · see citing works
The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction
Scheel-Krüger, J. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90037-5 · Cited by 1,277 · see citing works
Baxter, M. G., & Murray, E. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn875 · Cited by 1,200 · see citing works
The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning
LeDoux, J., Cicchetti, P., Xagoraris, A., & Romanski, L. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01062.1990 · Cited by 1,167 · see citing works
Chemical Signals in Vertebrates
Müller‐Schwarze, D., & Mozell, M. M. (1977) · Springer eBooks · doi:10.1007/978-1-4684-2364-8 · Cited by 1,142 · see citing works
Crouching as an index of fear.
Blanchard, R. J., & Blanchard, D. C. (1969) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0026779 · Cited by 1,077 · see citing works
The human amygdala and the emotional evaluation of sensory stimuli
Zald, D. H. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00248-5 · Cited by 1,062 · see citing works
T, L. (1957) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195707000-00025 · Cited by 1,045 · see citing works
The long and the short of long–term memory—a molecular framework
Goelet, P., Castellucci, V. F., Schacher, S., & Kandel, E. R. (1986) · Nature · doi:10.1038/322419a0 · Cited by 1,034 · see citing works
Pitkänen, A., Savander, V., & LeDoux, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01125-9 · Cited by 980 · see citing works
The Amygdala: a functional analysis
Aggleton, J. P. (2000) · Cited by 964 · see citing works
Quirk, G. J., Likhtik, E., Pelletier, J. G., & Paré, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08800.2003 · Cited by 927 · see citing works
Why We Think Plasticity Underlying Pavlovian Fear Conditioning Occurs in the Basolateral Amygdala
Fanselow, M. S., & LeDoux, J. E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80775-8 · Cited by 914 · see citing works
Jones, M. W., Errington, M. L., French, P. J., Fine, A., Bliss, T., Garel, S., Charnay, P., Bozon, B., Laroche, S., & Davis, S. (2001) · Nature Neuroscience · doi:10.1038/85138 · Cited by 899 · see citing works
From normal fear to pathological anxiety.
Rosen, J. B., & Schulkin, J. A. (1998) · Psychological Review · doi:10.1037/0033-295x.105.2.325 · Cited by 881 · see citing works
Self-citationCerebral hemisphere regulation of motivated behavior
Swanson, L. W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02905-x · Cited by 846 · see citing works
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
Walker, D. L., Toufexis, D. J., & Davis, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01282-2 · Cited by 838 · see citing works
A perceptual-defensive-recuperative model of fear and pain
Bolles, R. C., & Fanselow, M. S. (1980) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0000491x · Cited by 827 · see citing works
Miserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824 · see citing works
The Neurobiology of the Amygdala
Eleftheriou, B. E. (1972) · Advances in behavioral biology · doi:10.1007/978-1-4615-8987-7 · Cited by 813 · see citing works
Quirk, G. J., Repa, J. C., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90092-6 · Cited by 808 · see citing works
Fear conditioning induces a lasting potentiation of synaptic currents in vitro
McKernan, M. G., & Shinnick-Gallagher, P. (1997) · Nature · doi:10.1038/37605 · Cited by 771 · see citing works
Neurotransmission in the rat amygdala related to fear and anxiety
Davis, M., Rainnie, D., & Cassell, M. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90106-6 · Cited by 771 · see citing works
McDonald, A. J., Mascagni, F., & Guo, L. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00417-3 · Cited by 689 · see citing works
Schafe, G. E., Atkins, C. M., Swank, M. W., Bauer, E. P., Sweatt, J. D., & LeDoux, J. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08177.2000 · Cited by 674 · see citing works
Rapid and selective induction of BDNF expression in the hippocampus during contextual learning
Hall, J., Thomas, K. L., & Everitt, B. (2000) · Nature Neuroscience · doi:10.1038/75698 · Cited by 669 · see citing works
Fears, Phobias, and Rituals. Panic, Anxiety, and Their Disorders.
(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-607_3 · Cited by 665 · see citing works
Antipredator defensive behaviors in a visible burrow system
Blanchard, R. J., & Blanchard, D. C. (1989) · Journal of comparative psychology · doi:10.1037/0735-7036.103.1.70 · Cited by 663 · see citing works
Walker, D. L., & Davis, M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09375.1997 · Cited by 627 · see citing works
Schafe, G. E., & LeDoux, J. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0003.2000 · Cited by 611 · see citing works
Regulation of life and death by the zinc finger transcription factor Egr‐1
Thiel, G., & Cibelli, G. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10178 · Cited by 594 · see citing works
Factors governing one-trial contextual conditioning
Fanselow, M. S. (1990) · Animal Learning & Behavior · doi:10.3758/bf03205285 · Cited by 564 · see citing works
Quirk, G. J., Armony, J. L., & LeDoux, J. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80375-x · Cited by 563 · see citing works
Neurobiology of fear responses: the role of the amygdala
Davis, M. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.3.382 · Cited by 562 · see citing works
Beck, C., & Fibiger, H. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00709.1995 · Cited by 547 · see citing works
Are different parts of the extended amygdala involved in fear versus anxiety?
Davis, M. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00288-1 · Cited by 545 · see citing works
Canteras, N. S., & Swanson, L. W. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903240204 · Cited by 541 · see citing works
Fanselow, M. S., & Lester, L. S. (1988) · Cited by 511 · see citing works
Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo
Maren, S., & Fanselow (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07548.1995 · Cited by 499 · see citing works
Dielenberg, R. A., Hunt, G. E., & McGregor, I. S. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00150-6 · Cited by 487 · see citing works
Lee, S., Sadovsky, Y., Swirnoff, A. H., Polish, J. A., Goda, P., Gavrilina, G. B., & Milbrandt, J. (1996) · Science · doi:10.1126/science.273.5279.1219 · Cited by 480 · see citing works
Neuroimaging studies of amygdala function in anxiety disorders
RAUCH, S. L., SHIN, L. M., & WRIGHT, C. I. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07096.x · Cited by 463 · see citing works
The medial hypothalamic defensive system: Hodological organization and functional implications
Canteras, N. S. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00685-2 · Cited by 463 · see citing works
O’Donovan, K. J., Tourtellotte, W. G., Milbrandt, J., & Baraban, J. M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01343-5 · Cited by 457 · see citing works
Defensive behavior in rats towards predatory odors: a review
Dielenberg, R. A., & McGregor, I. S. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00044-6 · Cited by 453 · see citing works
Goosens, K. A., & Maren, S. (2001) · Learning & Memory · doi:10.1101/lm.37601 · Cited by 451 · see citing works
Two different lateral amygdala cell populations contribute to the initiation and storage of memory
Repa, J. C., Muller, J., Apergis, J., Desrochers, T. M., Zhou, Y., & LeDoux, J. E. (2001) · Nature Neuroscience · doi:10.1038/89512 · Cited by 440 · see citing works
Intrinsic connections of the rat amygdaloid complex: Projections originating in the basal nucleus
Savander, V., Go, C. ‐., LeDoux, J. E., & Pitkänen, A. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903610211 · Cited by 416 · see citing works
Connectivity of the rat amygdaloid complex
Pitkanen, A. (2000) · The Amygdala · doi:10.1093/oso/9780198505013.003.0002 · Cited by 400 · see citing works
Hall, J., Thomas, K. L., & Everitt, B. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02186.2001 · Cited by 381 · see citing works
Amorapanth, P., LeDoux, J. E., & Nader, K. (2000) · Nature Neuroscience · doi:10.1038/71145 · Cited by 374 · see citing works
Maren, S., Aharonov, G., Stote, D. L., & Fanselow, M. S. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.6.1365 · Cited by 372 · see citing works
Classical fear conditioning in functional neuroimaging
Büchel, C. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00078-7 · Cited by 350 · see citing works
Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06889.2001 · Cited by 350 · see citing works
Egr transcription factors in the nervous system
Beckmann, A. M., & Wilce, P. A. (1997) · Neurochemistry International · doi:10.1016/s0197-0186(96)00136-2 · Cited by 347 · see citing works
MAPK, CREB and zif268 are all required for the consolidation of recognition memory
Bozon, B., Kelly, A. M., Josselyn, S. A., Silva, A. J., Davis, S., & Laroche, S. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1224 · Cited by 327 · see citing works
Fanselow, M. S. (1986) · Learning and Motivation · doi:10.1016/0023-9690(86)90018-4 · Cited by 326 · see citing works
Bozon, B., Davis, S., & Laroche, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00674-3 · Cited by 317 · see citing works
Dayas, C. V., Buller, K. M., & Day, T. A. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00645.x · Cited by 303 · see citing works
The amygdala complex: multiple roles in associative learning and attention.
Gallagher, M., & Holland, P. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11771 · Cited by 300 · see citing works
A Positron Emission Tomographic Study of Simple Phobic Symptom Provocation
Rauch, S. L. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950130020003 · Cited by 298 · see citing works
Davis, S., Bozon, B., & Laroche, S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00421-7 · Cited by 281 · see citing works
Fendt, M., Endres, T., & Apfelbach, R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00023.2003 · Cited by 278 · see citing works
Afferent and Efferent Relationships of the Basal Ganglia
Nauta, W. J. H., & Domesick, V. B. (1984) · Novartis Foundation Symposia · doi:10.1002/9780470720882.ch2 · Cited by 272 · see citing works
Nader, K., Majidishad, P., Amorapanth, P., & LeDoux, J. E. (2001) · Learning & Memory · doi:10.1101/lm.38101 · Cited by 272 · see citing works
Wallace, K. J., & Rosen, J. B. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.5.912 · Cited by 264 · see citing works
Self-citationMaren, S., Aharonov, G., Stote, D. L., & Fanselow, M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1365 · Cited by 260 · see citing works
Pathways of Egr-1-Mediated Gene Transcription in Vascular Biology
Silverman, E. S., & Collins, T. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65312-6 · Cited by 253 · see citing works
McGregor, I. S., Schrama, L., Ambermoon, P., & Dielenberg, R. A. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00324-2 · Cited by 250 · see citing works
Is the Amygdala a Locus of “Conditioned Fear”? Some Questions and Caveats
Cahill, L. F., Weinberger, N. M., Roozendaal, B., & McGaugh, J. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80774-6 · Cited by 249 · see citing works
Conjunctive representations, the hippocampus, and contextual fear conditioning
RUDY, J. W., & O'REILLY, R. C. (2001) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.1.1.66 · Cited by 247 · see citing works
Radulović, J., Kammermeier, J., & Spiess, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07452.1998 · Cited by 245 · see citing works
Why are predator urines aversive to prey?
Nolte, D. L., Mason, J. R., Epple, G., Aronov, E., & Campbell, D. L. (1994) · Journal of Chemical Ecology · doi:10.1007/bf02059876 · Cited by 245 · see citing works
Kalin, N., Shelton, S., Davidson, R., & Kelley, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02067.2001 · Cited by 239 · see citing works
(2000) · doi:10.1093/oso/9780198505013.001.0001 · Cited by 229 · see citing works
Induction of the c-fos proto-oncogene in rat amygdala during unconditioned and conditioned fear
Campeau, S., Hayward, M. D., Hope, B. T., Rosen, J. B., Nestler, E. J., & Davis, M. (1991) · Brain Research · doi:10.1016/0006-8993(91)91669-r · Cited by 228 · see citing works
Self-citationPezzone, M. A., Lee, W., Hoffman, G. E., & Rabin, B. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91503-7 · Cited by 222 · see citing works
Poulton, R., & Menzies, R. G. (2002) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(01)00045-6 · Cited by 220 · see citing works
Response of nucleus accumbens neurons to amygdala stimulation and its modification by dopamine
Yim, C. Y., & Mogenson, G. J. (1982) · Brain Research · doi:10.1016/0006-8993(82)90518-2 · Cited by 210 · see citing works
Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.
Thiel, G., Schoch, S., & Petersohn, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36605-x · Cited by 204 · see citing works
Blanchard, D. C., Griebel, G., & Blanchard, R. J. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.012 · Cited by 201 · see citing works
Rosen, J. B., Fanselow, M. S., Young, S. L., Sitcoske, M., & Maren, S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00294-7 · Cited by 196 · see citing works
Self-citationSociety for Neuroscience Abstracts
Tonge, D., Ekström, P. A. R., Mayer, U., & Pizzey, J. A. (2001) · Cited by 195 · see citing works
Fredrikson, M., Wik, G., Annas, P., FRICSON, K., & Stone‐Elander, S. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb03404.x · Cited by 193 · see citing works
Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala
Hall, J., Thomas, K. L., & Everitt, B. J. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01531.x · Cited by 192 · see citing works
Chemical Signals in Vertebrates 15
Schaal, B., Keller, M., Rekow, D., & Damon, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-35159-4 · Cited by 191 · see citing works
Wallace, K. J., & Rosen, J. B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03619.2001 · Cited by 185 · see citing works
Self-citationMorrow, B. A., Redmond, A. J., Roth, R. H., & Elsworth, J. D. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02174-0 · Cited by 180 · see citing works
Induction of c-fos mRNA in rat brain by conditioned and unconditioned stressors
Smith, M. A., Banerjee, S., Gold, P. W., & Glowa, J. R. (1992) · Brain Research · doi:10.1016/0006-8993(92)90240-a · Cited by 173 · see citing works
Bozon, B., Davis, S., & Laroche, S. (2002) · Hippocampus · doi:10.1002/hipo.10100 · Cited by 172 · see citing works
Collins, D. R., & Paré, D. (2000) · Learning & Memory · doi:10.1101/lm.7.2.97 · Cited by 171 · see citing works
Acquisition of fear conditioning in rats requires the synthesis of mRNA in the amygdala.
Bailey, D. J., Kim, J. J., Sun, W. Y., Thompson, R. F., & Helmstetter, F. J. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.2.276 · Cited by 169 · see citing works
The Amygdala, Synaptic Plasticity, and Fear Memory
Maren, S. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07075.x · Cited by 159 · see citing works
Gewirtz, J. C., Mcnish, K. A., & Davis, M. (1998) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(98)00028-1 · Cited by 149 · see citing works
(1991) · Games and Economic Behavior · doi:10.1016/0899-8256(91)90002-v · Cited by 149 · see citing works
Structure-activity relationship of stress-inducing odorants in the rat
Vernet-Maury, E., Polak, E., & Demaël, A. (1984) · Journal of Chemical Ecology · doi:10.1007/bf00987509 · Cited by 146 · see citing works
The Human Synapsin II Gene Promoter
Petersohn, D., Schoch, S., Brinkmann, D. R., & Thiel, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.24361 · Cited by 144 · see citing works
Acquisition of fear conditioning in rats requires the synthesis of mRNA in the amygdala.
Bailey, D. J., Kim, J. J., Sun, W. Y., et al. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.2.276 · Cited by 144 · see citing works
Treit, D., Pesold, C., & Rotzinger, S. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.5.770 · Cited by 137 · see citing works
Cousens, G. A., & Otto, T. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.5.1092 · Cited by 136 · see citing works
Auditory-Evoked Spike Firing in the Lateral Amygdala and Pavlovian Fear Conditioning
Goosens, K. A., Hobin, J. A., & Maren, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00728-1 · Cited by 135 · see citing works
Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia
Wright, C. I., Martis, B., McMullin, K. G., Shin, L. M., & Rauch, S. L. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00548-1 · Cited by 130 · see citing works
Perspectives on anxiety, panic, and fear
Hope, D. A., & Dienstbier, R. A. (1996) · University of Nebraska Press eBooks · Cited by 124 · see citing works
Sun, N., Yi, H. L., & Cassell, M. D. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903400105 · Cited by 123 · see citing works
Rolli‐Derkinderen, M., Kotlyarov, A., Sakamoto, K. M., Gaestel, M., & Neininger, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19559 · Cited by 123 · see citing works
Malkani, S., & Rosen, J. B. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00058-0 · Cited by 120 · see citing works
Self-citationFendt, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04111.2001 · Cited by 117 · see citing works
Silverman, E. S., Du, J., WILLIAMS, A. J., Wadgaonkar, R., Drazen, J. M., & Collins, T. (1998) · Biochemical Journal · doi:10.1042/bj3360183 · Cited by 116 · see citing works
A functional cerebral response to frightening visual stimulation
Wik, G., Fredrikson, M., Ericson, K., Eriksson, L. I., Stone‐Elander, S., & Greitz, T. V. B. (1993) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(93)90020-i · Cited by 116 · see citing works
Habituation of the hiding response to cat odor in rats (Rattus norvegicus).
Dielenberg, R. A., & McGregor, I. S. (1999) · Journal of comparative psychology · doi:10.1037/0735-7036.113.4.376 · Cited by 116 · see citing works
Shors, T. J., & Mathew, P. R. (1998) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.5.3.220 · Cited by 111 · see citing works
Malkani, S., Wallace, K. J., Donley, M. P., & Rosen, J. (2004) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.73104 · Cited by 111 · see citing works
Self-citationBlanchard, D. C., Markham, C. M., Yang, M., Hubbard, D. T., Madarang, E., & Blanchard, R. J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.360 · Cited by 110 · see citing works
An Ethoexperimental Approach to the Study of Defense
Blanchard, R. J., Blanchard, D. C., & Hori, K. (1989) · Springer eBooks · doi:10.1007/978-94-009-2403-1_7 · Cited by 110 · see citing works
Treit, D., Pesold, C., & Rotzinger, S. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.5.770 · Cited by 109 · see citing works
Behavioral and neuropsychological foundations of olfactory fear conditioning
Otto, T., Cousens, G. A., & Herzog, C. D. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00190-4 · Cited by 108 · see citing works
Environmental control of defensive reactions to footshock
Blanchard, R. J., Fukunaga, K. K., & Blanchard, D. C. (1976) · Bulletin of the Psychonomic Society · doi:10.3758/bf03335103 · Cited by 106 · see citing works
Modulation of mice anxiety in response to cat odor as a consequence of predators diet
Berton, F., Vogel, E., & Belzung, C. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00126-7 · Cited by 105 · see citing works
Doyère, V., Schafe, G. E., Sigurdsson, T., & LeDoux, J. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02707.x · Cited by 101 · see citing works
Lisman, J. E., & Fallon, J. R. (1999) · Science · doi:10.1126/science.283.5400.339 · Cited by 98 · see citing works
Nijsen, M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00167-6 · Cited by 92 · see citing works
Morrow, B. A., Elsworth, J. D., & Roth, R. H. (2002) · Synapse · doi:10.1002/syn.10109 · Cited by 83 · see citing works
Born to fear: non-associative vs associative factors in the etiology of phobias
Mineka, S., & Öhman, A. (2002) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(01)00050-x · Cited by 83 · see citing works
Brief predator odour exposure activates the HPA axis independent of locomotor changes
Perrot-Sinal, T. S., Ossenkopp, K., & Kavaliers, M. (1999) · Neuroreport · doi:10.1097/00001756-199903170-00021 · Cited by 80 · see citing works
Funk, D. R., & Amir, S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02249-6 · Cited by 76 · see citing works
Gray, T. S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09281.x · Cited by 69 · see citing works
Criado, M., del Toro, E. D., Carrasco-Serrano, C., Smillie, F. I., Juiz, J. M., Viniegra, S., & Ballesta, J. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06554.1997 · Cited by 62 · see citing works
Burwash, M. D., Tobin, M. E., Woolhouse, A. D., & Sullivan, T. P. (1998) · Journal of Chemical Ecology · doi:10.1023/a:1022384728170 · Cited by 61 · see citing works
Walker, D. L., & Davis, M. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.4.692 · Cited by 61 · see citing works
Hotsenpiller, G., & Williams, J. L. (1997) · Psychobiology · doi:10.3758/bf03327031 · Cited by 54 · see citing works
The Basic, Somatic, And Emotional Components Of The Motor System In Mammals.
Holstege, G. (1995) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 53 · see citing works
Hebb, M. O., & Robertson, H. A. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00048-x · Cited by 49 · see citing works
Fears born and bred: non-associative fear acquisition?
Rachman, S. (2002) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(01)00044-4 · Cited by 47 · see citing works
Walker, D. L., & Davis, M. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.4.692 · Cited by 46 · see citing works
Malkani, S., & Rosen, J. B. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00531-5 · Cited by 44 · see citing works
Self-citationSchulkin, J. A., Thompson, B. L., & Rosen, J. B. (2003) · Brain and Cognition · doi:10.1016/s0278-2626(03)00004-6 · Cited by 44 · see citing works
Self-citationInduction of NGFI-B mRNA following contextual fear conditioning and its blockade by diazepam
Malkani, S., & Rosen, J. B. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00130-3 · Cited by 44 · see citing works
Self-citationFunctional anatomy: From molecule to memory
Dubnau, J., & Tully, T. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00115-4 · Cited by 44 · see citing works
Influence of some biologically meaningful odorants on the vigilance states of the rat
Cattarelli, M., & Chanel, J. (1979) · Physiology & Behavior · doi:10.1016/0031-9384(79)90186-0 · Cited by 42 · see citing works
Hebb, A. L. O., Zacharko, R. M., Gauthier, M. S., & Drolet, G. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03008-7 · Cited by 41 · see citing works
Innate and learned fears are at opposite ends of a continuum of associability
Marks, I. M. (2002) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(01)00048-1 · Cited by 36 · see citing works
Repellent Effect of Trimethyl Thiazoline in the Wild Rat Rattus Norvegicus Berkenhout
Vernet-Maury, E., Constant, B., & Chanel, J. (1992) · Springer eBooks · doi:10.1007/978-1-4757-9655-1_49 · Cited by 33 · see citing works
Lattal, K. M., & Abel, T. G. (2001) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.27.4.394 · Cited by 31 · see citing works
Freezing Behavior in BNST‐lesioned Wistar Rats
Schulz, D., & Canbeyli, R. S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09311.x · Cited by 20 · see citing works
Kagan, J., & Schulkin, J. A. (1995) · Harvard Review of Psychiatry · doi:10.3109/10673229509017190 · Cited by 16 · see citing works
Prospects of memory-modifying drugs that target the CREB pathway.
Jackson, T., & Ramaswami, M. (2003) · PubMed · Cited by 16 · see citing works
Giardino, N. D., Aloyz, R. S., Zollinger, M., Miller, M. W., & DesGroseillers, L. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961014)374:2 · Cited by 16 · see citing works
A Possible Case of Instinctive Behavior in the White Rat
Griffith, C. R. (1919) · Science · doi:10.1126/science.50.1285.166 · Cited by 14 · see citing works
Chapter 4.7 A neurobehavioral system approach in rats to study the molecular biology of fear
Rosen, J. B., Malkani, S., Wallace, K. J., & Thompson, B. L. (1999) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(99)80053-4 · Cited by 3 · see citing works
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Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · see citing works
Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review
Cisler, J. M., & Koster, E. H. W. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.11.003 · Cited by 1,753 · see citing works
Basic Emotions, Natural Kinds, Emotion Schemas, and a New Paradigm
Izard, C. E. (2007) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2007.00044.x · Cited by 1,110 · see citing works
Ventromedial hypothalamic neurons control a defensive emotion state
Kunwar, P. S., Zelikowsky, M., Remedios, R., Cai, H., Balban, M. Y., Meister, M., & Anderson, D. J. (2015) · eLife · doi:10.7554/elife.06633 · Cited by 1,112 · see citing works
Emotion regulation and the anxiety disorders: An integrative review
Cisler, J. M., Olatunji, B. O., Feldner, M. T., & Forsyth, J. P. (2010) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-009-9161-1 · Cited by 607 · see citing works
Freeze for action: neurobiological mechanisms in animal and human freezing
Roelofs, K. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0206 · Cited by 616 · see citing works
Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions
Chapman, C. R., Tuckett, R. P., & Song, C. W. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.09.006 · Cited by 541 · see citing works
The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior
Ziemann, A. E., Allen, J. E., Dahdaleh, N. S., Drebot, I. I., Coryell, M. W., Wunsch, A. M., Lynch, C. M., Faraci, F. M., Howard, M. A., Welsh, M. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.029 · Cited by 437 · see citing works
Extending animal models of fear conditioning to humans
Delgado, M. R., Olsson, A., & Phelps, E. A. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.006 · Cited by 366 · see citing works
Papes, F., Logan, D. W., & Stowers, L. (2010) · Cell · doi:10.1016/j.cell.2010.03.037 · Cited by 360 · see citing works
The smell of danger: A behavioral and neural analysis of predator odor-induced fear
Takahashi, L. K., Nakashima, B. R., Hong, H., & Watanabe, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.008 · Cited by 298 · see citing works
Kraus, K. S., & Canlon, B. (2012) · Hearing Research · doi:10.1016/j.heares.2012.02.009 · Cited by 263 · see citing works
Gore, F., Schwartz, E. C., Brangers, B. C., Aladi, S., Stujenske, J. M., Likhtik, E., Russo, M. J., Gordon, J. A., Salzman, C. D., & Axel, R. (2015) · Cell · doi:10.1016/j.cell.2015.06.027 · Cited by 256 · see citing works
Updating freeze: Aligning animal and human research
Hagenaars, M. A., Oitzl, M., & Roelofs, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.021 · Cited by 260 · see citing works
Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats
Pentkowski, N. S., Blanchard, D. C., Lever, C., Litvin, Y., & Blanchard, R. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04754.x · Cited by 244 · see citing works
Neural systems underlying approach and avoidance in anxiety disorders
Robin L., A., & Martin, P. P. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.4/raupperle · Cited by 227 · see citing works
Functional heterogeneity in the bed nucleus of the stria terminalis
Gungor, N. Z., & Pare, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0856-16.2016 · Cited by 214 · see citing works
Neural Mechanisms of Automatic and Direct Processing of Phobogenic Stimuli in Specific Phobia
Straube, T., Mentzel, H., & Miltner, W. H. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.013 · Cited by 184 · see citing works
Age-related alterations in hippocampal spines and deficiencies in spatial memory in mice
Halbach, O. V. B. U., Zacher, C., Gass, P., & Unsicker, K. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20759 · Cited by 173 · see citing works
Pentkowski, N. S., Rogge-Obando, K., Donaldson, T. N., Bouquin, S. J., & Clark, B. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.005 · Cited by 169 · see citing works
Neurobiology of anxiety disorders and implications for treatment.
Garakani, A., Mathew, S. J., & Charney, D. S. (2006) · PubMed · Cited by 165 · see citing works
TMT-induced autonomic and behavioral changes and the neural basis of its processing
Fendt, M., Endres, T., Lowry, C. A., Apfelbach, R., & McGregor, I. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.018 · Cited by 158 · see citing works
Knapska, E., Radwańska, K., Werka, T., & Kaczmarek, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00037.2006 · Cited by 152 · see citing works
Targeting ASIC1a Reduces Innate Fear and Alters Neuronal Activity in the Fear Circuit
Coryell, M. W., Ziemann, A. E., Westmoreland, P., Haenfler, J. M., Kurjakovic, Z., Zha, X., Price, M. P., Schnizler, M. K., & Wemmie, J. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.008 · Cited by 146 · see citing works
The medial geniculate, not the amygdala, as the root of auditory fear conditioning
Weinberger, N. M. (2010) · Hearing Research · doi:10.1016/j.heares.2010.03.093 · Cited by 142 · see citing works
Animal studies of amygdala function in fear and uncertainty: relevance to human research.
Rosen, J., & Donley, M. P. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.007 · Cited by 149 · see citing works
Self-citationIndividual differences in fear: Isolating fear reactivity and fear recovery phenotypes
Bush, D. E. A., Sotres-Bayón, F., & LeDoux, J. E. (2007) · Journal of Traumatic Stress · doi:10.1002/jts.20261 · Cited by 135 · see citing works
Rosen, J. B., Asok, A., & Chakraborty, T. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00292 · Cited by 132 · see citing works
Self-citationPopulation coding of valence in the basolateral amygdala
Zhang, X., & Li, B. (2018) · Nature Communications · doi:10.1038/s41467-018-07679-9 · Cited by 133 · see citing works
Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear
Yang, H., Yang, J., Wang, X., Hao, S., Luo, B., He, X., Zhu, L., Lou, H., Yu, Y., Xu, F., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4208 · Cited by 123 · see citing works
Staples, L., McGregor, I. S., Apfelbach, R., & Hunt, G. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.11.039 · Cited by 116 · see citing works
Roseboom, P. H., Nanda, S. A., Bakshi, V. P., Trentani, A., Newman, S. M., & Kalin, N. H. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.10.002 · Cited by 108 · see citing works
Kehne, J. H., & Cain, C. K. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.011 · Cited by 104 · see citing works
Fendt, M., & Endres, T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.010 · Cited by 105 · see citing works
Sink, K. S., Walker, D. L., Yang, Y., & Davis, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5274-10.2011 · Cited by 99 · see citing works
Predator odor-induced conditioned fear involves the basolateral and medial amygdala.
Takahashi, L. K., Hubbard, D. T., Lee, I., Dar, Y., & Sipes, S. M. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.1.100 · Cited by 94 · see citing works
Rosen, J. B., Pagani, J. H., Rolla, K. L. G., & Davis, C. L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.006 · Cited by 90 · see citing works
Self-citationCoryell, M. W., Wunsch, A. M., Haenfler, J. M., Allen, J. E., McBride, J. L., Davidson, B. L., & Wemmie, J. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3907-08.2008 · Cited by 91 · see citing works
Miki, K., Ishibashi, S., Sun, L., Xu, H., Ohashi, W., Kuroiwa, T., & Mizusawa, H. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21925 · Cited by 89 · see citing works
Experience-dependent plasticity in an innate social behavior is mediated by hypothalamic LTP
Stagkourakis, S., Spigolon, G., Liu, G., & Anderson, D. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011782117 · Cited by 90 · see citing works
Staples, L. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.09.009 · Cited by 89 · see citing works
Behavioral Changes Induced in Rats by Exposure to Trimethylthiazoline, a Component of Fox Odor.
Endres, T., Apfelbach, R., & Fendt, M. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.4.1004 · Cited by 87 · see citing works
A Comparative Analysis of the Preference for Dark Environments in Five Teleosts
Maximino, C., Marques, T. S., Dias, F., Cortes, F. V., Taccolini, I. B., Pereira, P. M., Colmanetti, R., Gazolla, R. A., Tavares, R. I., Rodrigues, S. T. K., et al. (2007) · International Journal of Comparative Psychology · doi:10.46867/ijcp.2007.20.04.02 · Cited by 84 · see citing works
Edinger, K. L., & Frye, C. A. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.03.003 · Cited by 84 · see citing works
Evolution of the Amygdala in Vertebrates
Martínez‐Garciá, F., Novejarque, A., & Lanuza, E. (2007) · Elsevier eBooks · doi:10.1016/b0-12-370878-8/00139-7 · Cited by 80 · see citing works
Chan, T., Kyere, K., Davis, B. R., Shemyakin, A., Kabitzke, P., Shair, H. N., Barr, G. A., & Wiedenmayer, C. P. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5216-10.2011 · Cited by 77 · see citing works
Predator odor fear conditioning: Current perspectives and new directions
Takahashi, L. K., Chan, M. M., & Pilar, M. L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.06.001 · Cited by 80 · see citing works
Diagnostic delay of oral squamous cell carcinoma and the fear of diagnosis: A scoping review
Mauceri, R., Bazzano, M., Coppini, M., Tozzo, P., Panzarella, V., & Campisi, G. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1009080 · Cited by 75 · see citing works
Wang, M. E., Fraize, N., Yin, L. X., Yuan, R. K., Petsagourakis, D., Wann, E. G., & Muzzio, I. A. (2013) · Hippocampus · doi:10.1002/hipo.22105 · Cited by 68 · see citing works
Plasticity of defensive behavior and fear in early development
Wiedenmayer, C. P. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.11.004 · Cited by 70 · see citing works
Cellular distribution of the fragile X mental retardation protein in the mouse brain
Zorio, D. A. R., Jackson, C. M., Liu, Y., Rubel, E. W., & Wang, Y. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24100 · Cited by 67 · see citing works
Vicente, M. A., & Zangrossi, H. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000873 · Cited by 67 · see citing works
Defensive responses of Wistar and Sprague-Dawley rats to cat odour and TMT
Staples, L., & McGregor, I. S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.04.011 · Cited by 67 · see citing works
Boissy, A., & Erhard, H. W. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394586-0.00003-2 · Cited by 66 · see citing works
Bystritsky, A., & Kronemyer, D. (2014) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2014.08.002 · Cited by 92 · see citing works
Postnatal development of the amygdala: A stereological study in rats
Chareyron, L. J., Lavenex, P. B., & Lavenex, P. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23132 · Cited by 61 · see citing works
Fendt, M., Bürki, H., Imobersteg, S., Lingenhöhl, K., McAllister, K. H., Orain, D., Uzunov, D. P., & Chaperon, F. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1610-8 · Cited by 61 · see citing works
Zoladz, P. R., & Diamond, D. M. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.003 · Cited by 61 · see citing works
Odor-induced recall of emotional memories in PTSD–Review and new paradigm for research
Daniels, J. K., & Vermetten, E. H. G. J. M. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.08.001 · Cited by 63 · see citing works
Vaillend, C., & Chaussenot, R. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx013 · Cited by 61 · see citing works
Taniguchi, T., Doe, N., Matsuyama, S., Kitamura, Y., Mori, H., Saito, N., & Tanaka, C. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.047 · Cited by 60 · see citing works
A role for delta opioid receptors in the central nucleus of the amygdala in anxiety-like behaviors
Randall-Thompson, J., Pescatore, K. A., & Unterwald, E. M. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1980-y · Cited by 58 · see citing works
Pregabalin Influences Insula and Amygdala Activation During Anticipation of Emotional Images
Aupperle, R. L., Ravindran, L. N., Tankersley, D., Flagan, T., Stein, N. R., Simmons, A. N., Stein, M. B., & Paulus, M. P. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.32 · Cited by 58 · see citing works
Diamond, D. M., & Zoladz, P. R. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23684 · Cited by 57 · see citing works
Rosen, J. B., West, E. A., & Donley, M. P. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.2.290 · Cited by 57 · see citing works
Self-citationPremotor sympathetic neurons of conditioned fear in the rat
Carrive, P., & Gorissen, M. C. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06351.x · Cited by 57 · see citing works
Neufeld-Cohen, A., Evans, A. K., Getselter, D., Spyroglou, A., Hill, A., Gil, S., Tsoory, M., Beuschlein, F., Lowry, C. A., Vale, W., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.115 · Cited by 57 · see citing works
Asok, A., Ayers, L. W., Awoyemi, B., Schulkin, J. A., & Rosen, J. B. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.047 · Cited by 57 · see citing works
Self-citationShallcross, J., Hámor, P. U., Bechard, A. R., Romano, M., Knackstedt, L. A., & Schwendt, M. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00091 · Cited by 57 · see citing works
Acute and chronic effects of ferret odor exposure in Sprague–Dawley rats
Campeau, S., Nyhuis, T. J., Sasse, S. K., Day, H. E. W., & Masini, C. V. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.014 · Cited by 55 · see citing works
Buron, G., Hacquemand, R., Pourié, G., Lucarz, A., Jacquot, L., & Brand, G. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.5.1063 · Cited by 55 · see citing works
Alterations in fear conditioning and amygdalar activation following chronic wheel running in rats
Burghardt, P. R., Pasumarthi, R. K., Wilson, M. A., & Fadel, J. R. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.05.015 · Cited by 53 · see citing works
Fear, risk assessment, and playfulness in the juvenile rat.
Siviy, S. M., Harrison, K. A., & McGregor, I. S. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.1.49 · Cited by 53 · see citing works
Role of gastrin-releasing peptide and neuromedin B in anxiety and fear-related behavior
Bédard, T., Mountney, C., Kent, P., Anisman, H., & Merali, Z. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.021 · Cited by 53 · see citing works
Merali, Z., Anisman, H., James, J. S., Kent, P., & Schulkin, J. A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06281.x · Cited by 53 · see citing works
Bajo, M., Madamba, S. G., Roberto, M., Blednov, Y. A., Sagi, V. N., Roberts, E., Rice, K. C., Harris, R. A., & Siggins, G. R. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.03.007 · Cited by 49 · see citing works
Xu, H. Y., Liu, Y., Xu, M.-Y., Zhang, Y., Zhang, J.-X., & Wu, Y.-J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.056 · Cited by 50 · see citing works
Defensive freezing and its relation to approach–avoidance decision-making under threat
Klaassen, F. H., Held, L. K., Figner, B., O’Reilly, J. X., Klumpers, F., de Voogd, L. D., & Karin Roelofs, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-90968-z · Cited by 49 · see citing works
Hacquemand, R., Choffat, N., Jacquot, L., & Brand, G. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.014 · Cited by 49 · see citing works
Fardell, L. L., Pavey, C., & Dickman, C. (2020) · PeerJ · doi:10.7717/peerj.9104 · Cited by 37 · see citing works
Linden, A.-M., Baez, M., Bergeron, M., & Schoepp, D. D. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.03.014 · Cited by 46 · see citing works
Asok, A., Schreiber, W. B., Jablonski, S. A., Rosen, J. B., & Stanton, M. E. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.006 · Cited by 44 · see citing works
Self-citationGait initiation is influenced by emotion processing in Parkinson's disease patients with freezing
Lagravinese, G., Pelosin, E., Bonassi, G., Carbone, F., Abbruzzese, G., & Avanzino, L. (2018) · Movement Disorders · doi:10.1002/mds.27312 · Cited by 43 · see citing works
σ1 receptor ligands control a switch between passive and active threat responses
Rennekamp, A. J., Huang, X., Wang, Y., Patel, S., Lorello, P. J., Cade, L., Gonzales, A. P. W., Yeh, J.-R. J., Caldarone, B. J., Roth, B. L., et al. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2089 · Cited by 42 · see citing works
Female fear: Influence of estrus cycle on behavioral response and neuronal activation
Chen, W., Shields, J. A., Huang, W., & King, J. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.019 · Cited by 42 · see citing works
Shiba, Y., Kim, C. R., Santangelo, A. M., & Roberts, A. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00250 · Cited by 41 · see citing works
Bhattacharya, S., Fontaine, A., MacCallum, P. E., Drover, J., & Blundell, J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00113 · Cited by 40 · see citing works
McCoy, C. R., Jackson, N. L., Day, J. J., & Clinton, S. M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.12.008 · Cited by 39 · see citing works
Galliot, E., Laurent, L., Hacquemand, R., Pourié, G., & Millot, J. (2012) · Behavioural Processes · doi:10.1016/j.beproc.2012.01.002 · Cited by 39 · see citing works
Prikas, E., Parić, E., Asih, P. R., Stefanoska, K., Stefen, H., Fath, T., Poljak, A., & Ittner, A. (2022) · The EMBO Journal · doi:10.15252/embj.2021110242 · Cited by 39 · see citing works
Conditioned behavioral responses to a context paired with the predator odor trimethylthiazoline.
Endres, T., & Fendt, M. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.3.594 · Cited by 38 · see citing works
Rosen, J. B., Adamec, R. E., & Thompson, B. L. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.04.001 · Cited by 38 · see citing works
Self-citationAversive learning of odor-heat associations in ants
Desmedt, L., Baracchi, D., Devaud, J., Giurfa, M., & d’Ettorre, P. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.161737 · Cited by 36 · see citing works
Janitzky, K., Stork, O., Lux, A., Yanagawa, Y., Schwegler, H., & Linke, R. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.038 · Cited by 35 · see citing works
Hacquemand, R., Jacquot, L., & Brand, G. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00188 · Cited by 34 · see citing works
Pentkowski, N. S., Litvin, Y., Blanchard, D. C., Vasconcellos, A., King, L. B., & Blanchard, R. J. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.02.007 · Cited by 34 · see citing works
Rodgers, K. M., Deming, Y. K., Bercum, F. M., Chumachenko, S. Y., Wieseler, J. L., Johnson, K. W., Watkins, L. R., & Barth, D. S. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.3090 · Cited by 33 · see citing works
Wintermann, G.-B., Donix, M., Joraschky, P., Gerber, J., & Petrowski, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074655 · Cited by 31 · see citing works
The fear circuitry in panic disorder and its modulation by cognitive-behaviour therapy interventions
de Carvalho, M. R., Rozenthal, M., & Nardi, A. E. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970903178176 · Cited by 31 · see citing works
Pagani, J., & Rosen, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.062 · Cited by 30 · see citing works
Self-citation
- Authors
- Rosen, J. B.
- Affiliations
- University of Delaware (US)
- Corresponding author
- Rosen, Jeffrey B.
- ORCID
- Rosen, Jeffrey B.
- Venue
- Behavioral and Cognitive Neuroscience Reviews
- Publisher
- SAGE Publications
- Published
- 2004-03
- Volume
- 3
- Issue
- 1
- Pages
- 23-41
- ISSN
- 1534-5823 (ISSN-L)
- 1552-4159
- OpenAlex
- W2094973377
- Cited by
- 219
- References
- 160
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 18 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 14 · 2015: 16 · 2014: 10 · 2013: 8 · 2012: 9
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral and Cognitive Neuroscience Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- fear conditioning, unconditioned fear, amygdala, basolateral amygdala, central amygdala, lateral amygdala, early growth response gene-1, contextual fear conditioning, predator odor, neural circuits, anxiety disorders, classical conditioning
- MeSH terms
- Amygdala, Animals, Behavior, Animal, Conditioning, Psychological, Fear, Nerve Net, Shock, Smell, Rats
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