Depressive rumination and the C957T polymorphism of the DRD2 gene
Open accessAbstract
Depressed individuals who ruminate have difficulties learning from punishment and suppressing task-irrelevant information. The C957T polymorphism of the DRD2 gene, which affects functioning of D2 dopamine receptors (DRD2) that are expressed predominantly in the indirect pathway of the basal ganglia, has been found to influence suppression and punishment learning. Given these associations, we examined in the present study whether depressive rumination is related to the C957T polymorphism in 317 clinically depressed individuals and 317 never-depressed control individuals. A 2 × 2 (diagnostic group ×C957T polymorphism) analysis of variance conducted on depressive rumination scores yielded a significant interaction of group and C957T: Individuals with two 957C alleles reported higher levels of depressive rumination than did individuals with one or two 957T alleles if they were depressed, but not if they were healthy. The present findings suggest that the dopaminergic system and DRD2 are related to the frequency of maladaptive rumination in depressed individuals. Thus, DRD2 may be an important target for the pharmacological treatment of depressive rumination.
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DRD2 appeared in all 14 GO gene-sets and in prior depression studies.
“DRD2 was included in all 14 of the putative Gene Ontology Consortium gene-sets identified (but not the somatosensory pyramidal neurons gene-set) and has been identified in previous studies of depression5, 9, 22.”
From Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions (2019) · cites this paper as [22]
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- Authors
- Whitmer, A. J., & Gotlib, I. H.
- Affiliations
- Stanford University (US)
- Corresponding author
- Whitmer, Anson J.
- ORCID
- Gotlib, Ian H.
- Venue
- Cognitive, Affective, & Behavioral Neuroscience
- Published
- 2012-08-04
- Volume
- 12
- Issue
- 4
- Pages
- 741-747
- ISSN
- 1530-7026 (ISSN-L)
- 1531-135X
- PMC
- PMC12787213
- OpenAlex
- W2064964376
- Cited by
- 30
- References
- 33
- Citations by year
- 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 3
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cognitive Affective & Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- National Institute of Mental Health (MH87115, MH59259, F32MH087115, R01MH059259)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- depressive rumination, DRD2 gene, dopamine D2 receptor, depression, punishment learning, dopaminergic system, genetic polymorphism
- MeSH terms
- Adult, Analysis of Variance, Depression, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Polymorphism, Genetic, Psychiatric Status Rating Scales, Receptors, Dopamine D2, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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