C-Reactive Protein and High-Sensitivity C-Reactive Protein: An Update for Clinicians
Abstract
The measurement of C-reactive protein (CRP) using both standard and high-sensitivity CRP (hs-CRP) assays is becoming common in clinical practice. This article addresses the causes of CRP elevation and the use of different CRP assays in internal medicine, including cardiology, gastroenterology, rheumatology, infectious diseases, and oncology. We focus on the recent medical literature on the use of hs-CRP in cardiovascular disease risk stratification and management, including updated screening guidelines on the use of hs-CRP, such as those issued in 2009 by the Canadian Cardiovascular Society. We also discuss the Reynolds Risk Score, which incorporates hs-CRP and family history with more standard cardiovascular risk factors (eg, tobacco use, hypertension, and dyslipidemia) and frequently leads to improved recategorization of cardiovascular disease risk levels. As the recently completed Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial indicated that statin therapy decreases the vascular events among persons with elevated hs-CRP by half, even when cholesterol levels are low, the inclusion of information on hs-CRP values with other cardiovascular risk factors may assist physicians in medical decision making for patients.
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CRP is easily measured through a blood sample also in its high-sensitivity form (hs-CRP).
“It is easily measured through a blood sample also in its high-sensitivity form (hs-CRP) [31]”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [31]
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C-Reactive protein as a biomarker for major depressive disorder?
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- Authors
- Windgassen, E. B., Funtowicz, L., Lunsford, T. N., Harris, L. A., & Mulvagh, S. L.
- Affiliations
- Mayo Clinic in Arizona (US)
- Mayo Clinic (US)
- Corresponding author
- Funtowicz, Luciana
- Venue
- Postgraduate Medicine
- Publisher
- Informa UK Limited
- Published
- 2011-01
- Volume
- 123
- Issue
- 1
- Pages
- 114-119
- ISSN
- 0032-5481 (ISSN-L)
- 1941-9260
- OpenAlex
- W2025353591
- Cited by
- 170
- References
- 39
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 15 · 2023: 14 · 2022: 11 · 2021: 13 · 2020: 13 · 2019: 7 · 2018: 11 · 2017: 12 · 2016: 12 · 2015: 6 · 2014: 13 · 2013: 14 · 2012: 7
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Postgraduate Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- C-reactive protein, high-sensitivity C-reactive protein, cardiovascular risk stratification, Reynolds Risk Score, JUPITER trial, rosuvastatin, statin therapy, cardiovascular risk factors, family history (medicine)
- MeSH terms
- Aspirin, C-Reactive Protein, Cardiovascular Diseases, Communicable Diseases, Gastrointestinal Diseases, Humans, Neoplasms, Rheumatic Diseases, Risk Factors, Biomarkers, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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