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Serine, glycine and one‑carbon metabolism in cancer (Review)
Open accessAbstract
Serine/glycine biosynthesis and one‑carbon metabolism are crucial in sustaining cancer cell survival and rapid proliferation, and of high clinical relevance. Excessive activation of serine/glycine biosynthesis drives tumorigenesis and provides a single carbon unit for one‑carbon metabolism. One‑carbon metabolism, which is a complex cyclic metabolic network based on the chemical reaction of folate compounds, provides the necessary proteins, nucleic acids, lipids and other biological macromolecules to support tumor growth. Moreover, one‑carbon metabolism also maintains the redox homeostasis of the tumor microenvironment and provides substrates for the methylation reaction. The present study reviews the role of key enzymes with tumor‑promoting functions and important intermediates that are physiologically relevant to tumorigenesis in serine/glycine/one‑carbon metabolism pathways. The related regulatory mechanisms of action of the key enzymes and important intermediates in tumors are also discussed. It is hoped that investigations into these pathways will provide new translational opportunities for human cancer drug development, dietary interventions, and biomarker identification.
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“Glycolysis supplies one-carbon metabolism through serine biosynthesis from 3-phosphoglycerate [37,49].”
From 20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells (2024) · cites this paper as [49]
In the citing paper
“The serine biosynthesis mediated by three enzymes—PSAT1, PHGDH, and PSAT1—“opens the gates” to one-carbon metabolism, whereas its central part—the folate cycle—mediates the re-distribution of one-carbon groups to acceptors [46] (Figure 11).”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [46]
In the citing paper
“Different oncogenes and oncosupressors have a critical impact on these metabolic pathways [20,40,46,47,75,76].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [46]
In the citing paper
“Transcription factors c-Myc and ATF4 are two master-regulators of glycolysis, respiration, and one-carbon metabolism [44,45,46,49].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [46]
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Metadata
- Authors
- Pan, S., Fan, M., Liu, Z., Li, X., & Wang, H.
- Affiliations
- Henan University (CN)
- Corresponding author
- Li, Xia
- Wang, Huijuan
- ORCID
- Venue
- International Journal of Oncology
- Publisher
- Spandidos Publications
- Published
- 2020-12-11
- Volume
- 58
- Issue
- 2
- Pages
- 158-170
- ISSN
- 1019-6439 (ISSN-L)
- 1791-2423
- PMC
- PMC7864012
- OpenAlex
- W3112083241
- Cited by
- 227
- References
- 166
- Citations by year
- 2026: 58 · 2025: 64 · 2024: 37 · 2023: 36 · 2022: 23 · 2021: 9
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- International Journal of Oncology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81872023)
- China Postdoctoral Science Foundation (2018M642742, 81872023)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- serine biosynthesis, glycine synthesis, one-carbon metabolism, folate metabolism, cancer metabolism, carcinogenesis, DNA methylation, anticancer drug development, dietary intervention, biomarkers
- MeSH terms
- Warburg Effect, Oncologic, Animals, Antineoplastic Agents, Carbon, Disease Models, Animal, Glycine, Humans, Methylation, Neoplasms, Oxidation-Reduction, Serine, Mice, Metabolic Networks and Pathways, Tumor Microenvironment, Carcinogenesis
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