Cited by 227Cancer, Hypoxia, and MetabolismFolate and B Vitamins ResearchCancer, Lipids, and Metabolism

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Serine, glycine and one‑carbon metabolism in cancer (Review)

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Pan, Sijing, Fan, Ming, Liu, Zhangnan, Li, Xia, Wang, Huijuan·2020·International Journal of Oncology

DOI 10.3892/ijo.2020.5158PMC PMC7864012

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Abstract

Serine/glycine biosynthesis and one‑carbon metabolism are crucial in sustaining cancer cell survival and rapid proliferation, and of high clinical relevance. Excessive activation of serine/glycine biosynthesis drives tumorigenesis and provides a single carbon unit for one‑carbon metabolism. One‑carbon metabolism, which is a complex cyclic metabolic network based on the chemical reaction of folate compounds, provides the necessary proteins, nucleic acids, lipids and other biological macromolecules to support tumor growth. Moreover, one‑carbon metabolism also maintains the redox homeostasis of the tumor microenvironment and provides substrates for the methylation reaction. The present study reviews the role of key enzymes with tumor‑promoting functions and important intermediates that are physiologically relevant to tumorigenesis in serine/glycine/one‑carbon metabolism pathways. The related regulatory mechanisms of action of the key enzymes and important intermediates in tumors are also discussed. It is hoped that investigations into these pathways will provide new translational opportunities for human cancer drug development, dietary interventions, and biomarker identification.

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Figure 1 The Serine-glycine biosynthesis pathway. The glycolysis pathway and glutamine catabolism provide an intermediate metabolite, 3-PG, which is gradually catalyzed into serine by PHGDH, PSAT1 and PSPH. Finally, serine is converted into glycine by SHMT1/2. Yellow ovals represent metabolic enzymes. 3-PG, 3-phosphoglycerate; 3-PHP, 3-phosphate hydroxypyruvate; 3-Pser, 3-phosphoserine; α-KG, α-ketoglutarate; OAA, oxaloacetate; PHGDH, phosphoglycerate dehydrogenase; PSAT, phosphoserine aminotransferase; PSPH, phosphoserine phosphatase; SHMT, serine hydroxymethyltransferase; TCA, tricarboxylic acid.CC BY-NC-ND · PubMed Central

Figure 2 Overview of one-carbon metabolism around the folate cycle, methionine cycle and trans-sulfuration pathway. The folate cycle provides one carbon for the methionine cycle, as well as homocysteine, an intermediate product of the methionine cycle, which can be converted into GSH through the trans-sulfuration pathway. Yellow ovals represent metabolic enzymes. 3-PG, 3-phosphoglycerate; BHMT, betaine homocysteine methyltransferase; CBS, cystathionine β-synthase; CTH, cystathionase; DHFR, dihydrofolate reductase; DMG, dimethylglycine; F-THF, 10-formyltetrahydrofolate; GLDC, glycine dehydrogenase; GSH, glutathione; HMT, histone methyl transferase; MAT, methionine adenosyltransferase; me-THF, 5,10-methylenetetrahydrofolate; mTHF, 5-methyl-tetrahydrofolate; MTHFD, methylenetetrahydrofolate dehydrogenase; MTHFR, methylenetetrahydrofolate reductase; MTR, methionine synthase; SAH, S-adenosyl homocysteine; SAHH, SAH hydrolase; SAM, S-adenosylmethionine; SHMT, serine hydroxymethyltransferase; SSP, serine synthesis pathway; THF, tetrahydrofolate.CC BY-NC-ND · PubMed Central

Figure 3 One-carbon metabolism integrates nutrient status and cellular functions with appropriate equilibrium in inputs and outputs. One-carbon metabolism can be viewed as a set of two modular units including the folate cycle and methionine cycle. The different nutrient sources and amino acids (serine, glycine, threonine, choline, betaine, methionine and vitamins) are inputted into the one-carbon metabolism and converted into a wide variety of outputs, such as nucleotide metabolism, redox control and post-translational modification. GSH, glutathione; ROS, reactive oxygen species.CC BY-NC-ND · PubMed Central

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See all 227

Authors: Pan, S., Fan, M., Liu, Z., Li, X., & Wang, H.
Affiliations: Henan University (CN)
Corresponding author: Li, Xia
Wang, Huijuan
ORCID: Li, Xia
Wang, Huijuan
Venue: International Journal of Oncology
Publisher: Spandidos Publications
Published: 2020-12-11
Volume: 58
Issue: 2
Pages: 158-170
ISSN: 1019-6439 (ISSN-L)
1791-2423
DOI: 10.3892/ijo.2020.5158
PMC: PMC7864012
OpenAlex: W3112083241
Cited by: 227
References: 166
Citations by year: 2026: 58 · 2025: 64 · 2024: 37 · 2023: 36 · 2022: 23 · 2021: 9
FWCI: 1.73
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
Locations: International Journal of Oncology (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81872023)
China Postdoctoral Science Foundation (2018M642742, 81872023)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: serine biosynthesis, glycine synthesis, one-carbon metabolism, folate metabolism, cancer metabolism, carcinogenesis, DNA methylation, anticancer drug development, dietary intervention, biomarkers
MeSH terms: Warburg Effect, Oncologic, Animals, Antineoplastic Agents, Carbon, Disease Models, Animal, Glycine, Humans, Methylation, Neoplasms, Oxidation-Reduction, Serine, Mice, Metabolic Networks and Pathways, Tumor Microenvironment, Carcinogenesis

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