The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
Clinical applications of mesenchymal stem cells
Open accessAbstract
Mesenchymal stem cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation and exert potent immunosuppressive and anti-inflammatory effects through interactions between lymphocytes associated with both the innate and adaptive immune system. Along with these unique therapeutic properties, their ease of accessibility and expansion suggest that use of MSCs may be a useful therapeutic approach for various disorders. In the clinical setting, MSCs are being explored in trials of various conditions, including orthopedic injuries, graft versus host disease following bone marrow transplantation, cardiovascular diseases, autoimmune diseases, and liver diseases. Furthermore, genetic modification of MSCs to overexpress antitumor genes has provided prospects for clinical use as anticancer therapy. Here, we highlight the currently reported uses of MSCs in clinical trials and discuss their efficacy as well as their limitations.
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1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
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RetractedMultilineage potential of adult human mesenchymal stem cells
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Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies
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Human mesenchymal stem cells modulate allogeneic immune cell responses
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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
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Bone Marrow as a Potential Source of Hepatic Oval Cells
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Cited by
Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning
Ferreira, J. R., Teixeira, G. Q., Santos, S. G., Barbosa, M. A., Almeida-Porada, G., & Gonçalves, R. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02837 · Cited by 572
Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review
Rodríguez-Fuentes, D. E., Fernández-Garza, L. E., Samia-Meza, J. A., Barrera-Barrera, S. A., Caplan, A. I., & Barrera-Saldaña, H. A. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2020.08.006 · Cited by 376
Saeedi, P., Halabian, R., & Imani Fooladi, A. A. (2019) · Stem Cell Investigation · doi:10.21037/sci.2019.08.11 · Cited by 251
Darnell, M., O’Neil, A., Mao, A., Gu, L., Rubin, L. L., & Mooney, D. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802568115 · Cited by 120
Practical Use of Immortalized Cells in Medicine: Current Advances and Future Perspectives
Voloshin, N., Tyurin-Kuzmin, P., Karagyaur, M., Akopyan, Z., & Kulebyakin, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612716 · Cited by 77
Metadata
- Authors
- Kim, N., & Cho, S.-G.
- Venue
- The Korean Journal of Internal Medicine
- Published
- 2013
- Volume
- 28
- Issue
- 4
- Pages
- 387
- ISSN
- 1226-3303 (ISSN-L)
- 2005-6648
- OpenAlex
- W2072308381
- Cited by
- 314
- References
- 146
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
