Bifidobacterium pseudocatenulatum CECT 7765 ameliorates neuroendocrine alterations associated with an exaggerated stress response and anhedonia in obese mice
Abstract
Obesity, besides being a problem of metabolic dysfunction, constitutes a risk factor for psychological disorders. Experimental models of diet-induced obesity have revealed that obese animals are prone to anxious and depressive-like behaviors. The present study aimed to evaluate whether Bifidobacterium pseudocatenulatum CECT 7765 could reverse the neurobehavioral consequences of obesity in a high-fat diet (HFD) fed mouse model via regulation of the gut-brain axis. Adult male wild-type C57BL-6 mice were fed a standard diet or HFD, supplemented with either placebo or the bifidobacterial strain for 13 weeks. Behavioral tests were performed, and immune and neuroendocrine parameters were analyzed including leptin and corticosterone and their receptors, Toll-like receptor 2 (TLR2) and neurotransmitters. We found that obese mice showed anhedonia (p < 0.050) indicative of a depressive-like behavior and an exaggerated hypothalamic-pituitary axis (HPA)-mediated stress response to acute physical (p < 0.001) and social stress (p < 0.050), but these alterations were ameliorated by B. pseudocatenulatum CECT 7765 (p < 0.050). These behavioral effects were parallel to reductions of the obesity-associated hyperleptinemia (p < 0.001) and restoration of leptin signaling (p < 0.050), along with fat mass loss (p < 0.010). B. pseudocatenulatum CECT 7765 administration also led to restoration of the obesity-induced reductions in adrenaline in the hypothalamus (p < 0.010), involved in the hypothalamic control of energy balance. Furthermore, the bifidobacterial strain reduced the obesity-induced upregulation of TLR2 protein or gene expression in the intestine (p < 0.010) and the hippocampus (p < 0.050) and restored the alterations of 5-HT levels in the hippocampus (p < 0.050), which could contribute to attenuating the obesity-associated depressive-like behavior (p < 0.050). In summary, the results indicate that B. pseudocatenulatum CECT 7765 could play a role in depressive behavior comorbid with obesity via regulation of endocrine and immune mediators of the gut-brain axis.
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The probiotic B. pseudocatenulatum (CECT 7765) reversed glucocorticoid receptor and stress response abnormalities, along with the neuro-behavioral phenotype, in a diet-induced obesity model.
“The probiotic B. pseudocatenulatum (CECT 7765) reversed the glucocorticoid receptor and stress response abnormalities, along with the neuro-behavioral phenotype.”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [366]
In an animal model of diet-induced obesity, anxious and depressive-like behaviors were associated with decreased hippocampal levels of glucocorticoid receptors and an exaggerated HPA axis-mediated stress response to acute physical and social stress.
“In an animal model of diet-induced obesity, anxious and depressive-like behaviors were associated with decreased hippocampal levels of glucocorticoid receptors and an exaggerated HPA axis-mediated stress response to acute physical and social stress (366).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [366]
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- Authors
- Agusti, A., Moya-Pérez, A., Campillo, I., Montserrat-de la Paz, S., Cerrudo, V., Perez-Villalba, A., & Sanz, Y.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Sanz, Yolanda
- Venue
- Molecular Neurobiology
- Published
- 2017-09-18
- Volume
- 55
- Issue
- 6
- Pages
- 5337-5352
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2755816326
- Cited by
- 85
- References
- 74
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 17 · 2020: 9 · 2019: 8 · 2018: 8
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the Spanish Ministry of Economy and Competitiveness (MINECO) (AGL2014-52101-P)
- MECD
- MINECO (PTA)
- CIBERNED
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- Bifidobacterium pseudocatenulatum, obesity, gut-brain axis, anhedonia, depression-like behavior, hypothalamic-pituitary-adrenal axis, stress response, leptin signaling, hyperleptinemia, TLR2, serotonin, epinephrine, high-fat diet, probiotics, neuroendocrine changes, hippocampus, social stress
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Bifidobacterium, Catecholamines, Corticosterone, Depression, Feces, Male, Mice, Inbred C57BL, Mice, Obese, Motor Activity, Neurosecretory Systems, Receptors, Glucocorticoid, Serotonin, Stress, Physiological, Weight Gain, Leptin, Adiposity, Toll-Like Receptor 2, Receptors, Leptin, Anhedonia
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