Effect of Bifidobacterium breve B-3 on skin photoaging induced by chronic UV irradiation in mice
Abstract
Probiotics have been shown to have a preventative effect on skin photoaging induced by short term UV irradiation, however, the underlying mechanisms and the effect of probiotics on skin photoaging induced by chronic UV irradiation remain unclear. In this study, we investigated the effect of Bifidobacterium breve B-3 on skin photoaging induced by chronic UV irradiation in hairless mice. Mice were irradiated with UVB three times weekly and orally administered B. breve B-3 (2×10(9) cfu/mouse /day) for 7 weeks. Nonirradiated mice and UVB-irradiated mice without probiotic treatment were used as controls. B. breve B-3 significantly suppressed the changes of transepidermal water loss, skin hydration, epidermal thickening and attenuated the damage to the tight junction structure and basement membrane induced by chronic UVB irradiation. Administration of B. breve B-3 tended to suppress the UV-induced interleukin-1β production in skin (P=0.09). These results suggest that B. breve B-3 could potentially be used to prevent photoaging induced by chronic UV irradiation.
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Oral supplementation with bifidobacterium breve B-3 improved skin photoaging induced by chronic UV irradiation in mice.
“Oral supplementation with bifidobacterium breve B-3 improved skin photoaging induced by chronic UV irradiation in mice.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [15]
B. breve B-3 markedly relieved transepidermal water loss and epidermal thickening, suppressed damage to tight junction structure and basement membrane, and attenuated production of IL-1beta in skin.
“B. breve B-3 markedly relieved transepidermal water loss and epidermal thickening, suppressed the damage to the tight junction structure and basement membrane, and attenuated the production of IL-1β in skin [15].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [15]
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- Authors
- Satoh, T., Murata, M., Iwabuchi, N., Odamaki, T., Wakabayashi, H., Yamauchi, K., Abe, F., & Xiao, J. Z.
- Affiliations
- Morinaga Milk Industry Co., Ltd. (Japan) (JP)
- Venue
- Beneficial Microbes
- Publisher
- Walter de Gruyter GmbH
- Published
- 2015-08
- Volume
- 6
- Issue
- 4
- Pages
- 497-504
- ISSN
- 1876-2883 (ISSN-L)
- 1876-2891
- OpenAlex
- W1994844419
- Cited by
- 61
- References
- 40
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 9 · 2021: 11 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Beneficial Microbes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- photoaging, probiotics, transepidermal water loss, skin hydration, epidermal thickening, tight junctions, basement membrane, IL-1β, hairless mice
- MeSH terms
- Animals, Bifidobacterium, Male, Mice, Hairless, Skin, Ultraviolet Rays, Skin Aging, Probiotics, Interleukin-1beta
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