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Biological Significance of Ascorbic Acid (Vitamin C) in Human Health - A Review
Open accessAbstract
The recognition of vitamin C (Ascorbic acid) is associated with history of an unrelenting search for the cause of the ancient hemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radicals` damages. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps fight off infections.
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“Vitamin C is crucial for immune system function [1,2,3,4] and protects against damage from reactive oxygen species [5,6].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [5]
In the citing paper
“Consequently, adequate cell and tissue stores of vitamin C maintain resistance to infections [5].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [5]
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“Ascorbic acid also helps in reduction of severe allergic reactions, fighting the infections, and most importantly in the proper regulation and functioning of the immune system.([25])”
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“Furthermore, ascorbic acid can revitalize other antioxidant compounds like α-tocopheroxyl and β-carotene radical cations from their radical species [36], and can rejuvenate vitamin E [37].”
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“Besides, vitamin C plays an essential role in the formation of norepinephrine from dopamine (Iqbal et al., 2004), which eventually increases the availability of norepinephrine essential in the successful performance of beam walk task.”
BackgroundAntioxidant Role of Ascorbic Acid and His Protective Effects on Chronic Diseases
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“In addition, ascorbate is known to ameliorate iron uptake in humans (Iqbal et al., 2004).”
BackgroundInfluentialHemotoxicity Induced by Chronic Chlorpyrifos Exposure in Wistar Rats: Mitigating Effect of Vitamin C
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Evaluation of in vitro Antioxidant Activities of Lemon Juice for Safety Assessment
Hajimahmoo, M., Aliabadipo, M., Moghaddam, G., Sadeghi, N., Oveisi, M., & Jannat, B. (2012) · doi:10.3923/ajft.2012.708.714 · Cited by 24
Sun, P., Li, D.-F., Dong, B., Qiao, S., Ma, X., & Chen, X. (2009) · doi:10.1016/j.foodchem.2008.08.018 · Cited by 24
Aryal, K. P., & Jeong, H. K. (2020) · Chemical Physics Letters · doi:10.1016/j.cplett.2020.137881 · Cited by 23
Yield and fruit quality of sweet pepper depending on foliar application of calcium
Buczkowska, H., Michałojć, Z., & Nurzyńska-Wierdak, R. (2016) · doi:10.3906/tar-1501-56 · Cited by 23
“L-ascorbic acid is one of the most important nutrients of pepper due to its wide biological activity in the human body (Iqbal et al., 2004; Hacişevki, 2009).”
BackgroundIkram, M., Mizuno, R., Putri, S., & Fukusaki, E. (2021) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2021.08.008 · Cited by 22
Zhang, J., Tian, J.-L., Gao, N.-X., Gong, E.-S., Xin, G., Liu, C.-J., Si, X., Sun, X.-Y., & Li, B. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2525 · Cited by 22
“In this study, the vitamin C content of kiwi berries ranged from 54.32 to 93.94 mg/100 g FW, which was higher than that of orange (51 mg/100 g FW), strawberry (29– 48 mg/100 g FW) (Iqbal et al., 2004), and traditional kiwifruit (Ewa BaranowskaWójcik, 2019).”
BackgroundInfluentialAryal, K. P., & Jeong, H. K. (2021) · Chemical Physics Letters · doi:10.1016/j.cplett.2021.138405 · Cited by 29
Musa, A., & Ogbadoyi, E. (2012) · doi:10.4172/2155-9600.1000140 · Cited by 22
Gubanska, I., Kucińska‐Lipka, J., & Janik, H. (2019) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2019.02.025 · Cited by 21
Addy, P. S., Bhattacharya, A., Mandal, S. M., & Basak, A. (2014) · RSC Advances · doi:10.1039/c4ra07499h · Cited by 29
Loguercio, L. F., Thesing, A., Noremberg, B. S., Lopes, B. V., Maron, G. K., Machado, G., Pope, M. A., & Carreño, N. L. V. (2022) · ChemElectroChem · doi:10.1002/celc.202200334 · Cited by 19
Banavath, R., Srivastava, R., & Bhargava, P. (2022) · Electrochimica Acta · doi:10.1016/j.electacta.2022.140335 · Cited by 20
Milošević, M., Paunović, M. G., Matić, M., Ognjanović, B., & Saicic, Z. (2017) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2017.09.016 · Cited by 20
Ismail, T. A., Soliman, M. M., NASSAN, M. A., & Mohamed, D. I. (2015) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-3-2-1 · Cited by 20
Patil, R., Gholave, A., Jadhav, J., Yadav, S., & Bapat, V. (2014) · Genetic Resources and Crop Evolution · doi:10.1007/s10722-014-0164-8 · Cited by 20
“Vitamin C has many health effective functions by preventing disorders like diabetes, cataracts, stroke heart diseases, cancer etc. (Iqbal et al. 2004).”
BackgroundAl-Shmgani, H. S., Moate, R. M., MACNAUGHTON, P. D., Sneyd, J. R., & Moody, A. J. (2013) · FEBS Journal · doi:10.1111/febs.12413 · Cited by 17
Micronutrients and Breast Cancer Progression: A Systematic Review
Cuenca-Micó, O., & Aceves, C. (2020) · Nutrients · doi:10.3390/nu12123613 · Cited by 23
Could vitamin C and zinc chloride protect the germ cells against sodium arsenite?
Altoé, L., Reis, I., Gomes, M., Dolder, H., & Pirovani, J. C. M. (2016) · Human & Experimental Toxicology · doi:10.1177/0960327116679714 · Cited by 16
Kolaviron and L-Ascorbic Acid Attenuate Chlorambucil-Induced Testicular Oxidative Stress in Rats
Olayinka, E. T., & Ore, A. (2014) · Journal of Toxicology · doi:10.1155/2014/587015 · Cited by 18
Fruit crops improvement using CRISPR/Cas9 system
Kaur, N., Awasthi, P., & Tiwari, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818140-9.00012-x · Cited by 22
Hfaiedh, N., Murat, J., & Elfeki, A. (2012) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2012.04.002 · Cited by 17
A study on the effect of natural products against the transmission of B.1.1.529 Omicron
Alkafaas, S. S., Abdallah, A. M., Hussien, A. M., Bedair, H., Abdo, M., Ghosh, S. B., Elkafas, S. S., Apollon, W., Saki, M., Loutfy, S. A., et al. (2023) · Virology Journal · doi:10.1186/s12985-023-02160-6 · Cited by 20
Gil, K., Nowicka, P., Wojdyło, A., Serreli, G., Deiana, M., & Tuberoso, C. (2023) · Antioxidants · doi:10.3390/antiox12040805 · Cited by 16
“[69], ascorbic acid is an antioxidant that protects humans from oxidative stress damage.”
BackgroundEgbuniwe, I. C., Ayo, J., Kawu, M., & Mohammed, A. (2018) · Journal of Applied Animal Welfare Science · doi:10.1080/10888705.2018.1426000 · Cited by 16
Modulation of mutagen-induced genotoxicity by vitamin C and medicinal plants in Allium cepa L.
Asita, A. O., Moramang, S., Rants’o, T., & Magama, S. (2017) · Caryologia · doi:10.1080/00087114.2017.1311166 · Cited by 16
“Vitamin C (ascorbic acid; AA) is a water soluble antioxidant which is found in variable quantities in fruits, vegetables and medicinal plants (Szeto et al. 2002; Iqbal et al. 2004; Ogunlesi et al. 2010).”
BackgroundNatural Bioactive Compounds from Fruits and Vegetables as Health Promoters: Part 2
Silva, L. R. D. D., Silva, B., Nunes, A. R., Mg, A., Oliveira, P., Silva, L. R., Silva, B., Duarte, A., Carvalho, C., Miguel, G., et al. (2016) · doi:10.2174/97816810823941160101 · Cited by 16
Teepoo, S., Chumsaeng, P., Jongjinako, S., Chantu, K., & Nolykad, W. (2012) · doi:10.3923/jas.2012.568.574 · Cited by 16
Metadata
- Authors
- Iqbal, K., Khan, A., & Khan Khattak, M. M. A.
- Venue
- Pakistan Journal of Nutrition
- Publisher
- Science Insights
- Published
- 2003-12-15
- Volume
- 3
- Issue
- 1
- Pages
- 5-13
- ISSN
- 1680-5194 (ISSN-L)
- 1994-7984
- OpenAlex
- W2111933236
- Cited by
- 270
- References
- 94
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 23 · 2023: 20 · 2022: 18 · 2021: 23 · 2020: 21 · 2019: 25 · 2018: 15 · 2017: 7 · 2016: 20 · 2015: 19 · 2014: 21 · 2013: 9 · 2012: 13
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Pakistan Journal of Nutrition (publishedVersion, cc-by)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- vitamin C, scurvy, connective tissue, bone formation, wound healing, gingival health, folic acid, bile acid synthesis, antioxidants, free radicals, immune system, allergy, infection
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