Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

Levine, Glenn N.; Frei, Balz; Koulouris, Spyridon N.; Gerhard, Marie D.; Keaney, John F.; Vita, Joseph A.

doi:10.1161/01.cir.93.6.1107

Cited by 582Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

Levine, Glenn N., Frei, Balz, Koulouris, Spyridon N., Gerhard, Marie D., Keaney, John F., Vita, Joseph A.·1996·Circulation

DOI 10.1161/01.cir.93.6.1107

Open this paper in CoChat — free account

Abstract

Background In the setting of atherosclerosis, endothelial vasomotor function is abnormal. Increased oxidative stress has been implicated as one potential mechanism for this observation. We therefore hypothesized that an antioxidant, ascorbic acid, would improve endothelium-dependent arterial dilation in patients with coronary artery disease. Methods and Results Brachial artery endothelium-dependent dilation in response to hyperemia was assessed by high-resolution vascular ultrasound before and 2 hours after oral administration of either 2 g ascorbic acid or placebo in a total of 46 patients with documented coronary artery disease. Plasma ascorbic acid concentration increased 2.5-fold 2 hours after treatment (46±8 to 114±11 μmol/L, P =.001). In the prospectively defined group of patients with an abnormal baseline response (<5% dilation), ascorbic acid produced marked improvement in dilation (2.0±0.6% to 9.7±2.0%), whereas placebo had no effect (1.1±1.5% to 1.7±1.5%, P =.003 for ascorbic acid versus placebo). Ascorbic acid had no effect on hyperemic flow or arterial dilation to sublingual nitroglycerin. Conclusions Ascorbic acid reverses endothelial vasomotor dysfunction in the brachial circulation of patients with coronary artery disease. These findings suggest that increased oxidative stress contributes to endothelial dysfunction in patients with atherosclerosis and that endothelial dysfunction may respond to antioxidant therapy.

Integrity signals

Registry

Crossref · 10.1161/01.cir.93.6.1107

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hyperglycemic patients experiencing vasodilation have a positive effect following intravenous administration (24 mg/min for 10 min) or oral dose (6 g during 2 days) of vitamin C.
“Hyperglycemic patients experiencing vasodilation have a positive effect following intravenous administration (24 mg/min for 10 min) or oral dose (6 g during 2 days) (Levine et al. 1996).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Levine et al. 1996

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744 · see citing works
Role of oxidized low density lipoprotein in atherogenesis.
Witztum, J. L., & Steinberg, D. H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115499 · Cited by 2,682 · see citing works
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
Ludmer, P. L., Selwyn, A. P., Shook, T., Wayne, R. R., Mudge, G. H., Alexander, R. W., & Ganz, P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610233151702 · Cited by 2,422 · see citing works
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,407 · see citing works
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,335 · see citing works
Vitamin E Consumption and the Risk of Coronary Disease in Women
Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282003 · Cited by 2,085 · see citing works
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870 · see citing works
Self-citation
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765 · see citing works
S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.
Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T. M., Singel, D. J., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.444 · Cited by 1,471 · see citing works
Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women
Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,334 · see citing works
Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction
Celermajer, D. S., Sørensen, K. E., Bull, C., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90141-4 · Cited by 1,228 · see citing works
Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.
Vita, J. A., Treasure, C. B., Nabel, E. G., McLenachan, J. M., Fish, R. D., Yeung, A. C., Vekshtein, V. I., Selwyn, A. P., & Ganz, P. (1990) · Circulation · doi:10.1161/01.cir.81.2.491 · Cited by 1,172 · see citing works
Self-citation
Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide
Myers, P. R., Minor, R. L., Guerra, R., Bates, J. N., & Harrison, D. G. (1990) · Nature · doi:10.1038/345161a0 · Cited by 973 · see citing works
Glutathione-ascorbic acid antioxidant system in animals
Meister, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36891-6 · Cited by 812 · see citing works
Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women
Lieberman, E. H., Gerhard, M. D., Uehata, A., Walsh, B. W., Selwyn, A. P., Ganz, P., Yeung, A. C., & Creager, M. A. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00005 · Cited by 701 · see citing works
Self-citation
The antioxidant role of vitamin C
Bendich, A., Machlin, L. J., Scandurra, O., Burton, G. W., & Wayner, D. D. M. (1986) · Advances in free radical biology and medicine · doi:10.1016/s8755-9668(86)80021-7 · Cited by 684 · see citing works
The Effect of Atherosclerosis on the Vasomotor Response of Coronary Arteries to Mental Stress
Yeung, A. C., Vekshtein, V. I., Krantz, D. S., Vita, J. A., Ryan, T. J., Ganz, P., & Selwyn, A. P. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111283252205 · Cited by 599 · see citing works
Self-citation
Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level.
Sørensen, K. E., Celermajer, D. S., Georgakopoulos, D., Hatcher, G. W., Betteridge, D. J., & Deanfield, J. E. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116983 · Cited by 578 · see citing works
Free radicals mediate endothelial cell dysfunction caused by elevated glucose
Tesfamariam, B., & Cohen, R. A. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.2.h321 · Cited by 558 · see citing works
Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test.
Nabel, E. G., Ganz, P., Gordon, J. B., Alexander, R. W., & Selwyn, A. P. (1988) · Circulation · doi:10.1161/01.cir.77.1.43 · Cited by 555 · see citing works
The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective
Winkler, B. S., Orselli, S. M., & Rex, T. S. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90019-1 · Cited by 491 · see citing works
Natural Antioxidants in Human Health and Disease
(1994) · Elsevier eBooks · doi:10.1016/c2009-0-03361-3 · Cited by 427 · see citing works
Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients
Golino, P., Piscione, F., Willerson, J. T., Cappelli-Bigazzi, M., Focaccio, A., Villari, B., Indolfi, C., Russolillo, E., Condorelli, M., & Massimo Chiariello, A. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103073241001 · Cited by 425 · see citing works
Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.
Cox, D. A., Vita, J. A., Treasure, C. B., Fish, R. D., Alexander, R. W., Ganz, P., & Selwyn, A. P. (1989) · Circulation · doi:10.1161/01.cir.80.3.458 · Cited by 413 · see citing works
Self-citation
Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise.
Gordon, J. B., Ganz, P., Nabel, E. G., Fish, R. D., Zebede, J., Mudge, G. H., Alexander, R. W., & Selwyn, A. P. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114103 · Cited by 367 · see citing works
NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.
Keaney, J. F., Simon, D. I., Stamler, J. S., Jaraki, O., Scharfstein, J., Vita, J. A., & Loscalzo, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116364 · Cited by 298 · see citing works
Self-citation
In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols.
Scharfstein, J., Keaney, J. F., Slivka, A., Welch, G. N., Vita, J. A., Stamler, J. S., & Loscalzo, J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117480 · Cited by 288 · see citing works
Self-citation
Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin c in the presence of transition metal ions
Retsky, K. L., Freeman, M. W., & Frei, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54075-8 · Cited by 271 · see citing works
Self-citation
Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol
Cooke, J. P., Stamler, J. S., Andon, N., Davies, P. F., McKinley, G., & Loscalzo, J. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.3.h804 · Cited by 257 · see citing works
N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.
Stamler, J. S., Mendelsohn, M. E., Amarante, P., Smick, D., Andon, N., Davies, P. F., Cooke, J. P., & Loscalzo, J. (1989) · Circulation Research · doi:10.1161/01.res.65.3.789 · Cited by 243 · see citing works
Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation.
Keaney, J. F., Xu, A., Cunningham, D., Jackson, T. S., Frei, B. B., & Vita, J. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117953 · Cited by 198 · see citing works
Self-citation
Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.
Keaney, J. F., Gaziano, J. M., Xu, A., Frei, B. B., Curran-Celentano, J., Shwaery, G. T., Loscalzo, J., & Vita, J. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11880 · Cited by 198 · see citing works
Self-citation
Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action
Keaney, J. F., & Vita, J. A. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(05)80003-9 · Cited by 195 · see citing works
Self-citation
Relationship of angiographically defined coronary artery disease to serum lipoproteins and apolipoproteins in young survivors of myocardial infarction.
Hamsten, A., Walldius, G., Szamosi, A., Dahlén, G., & Fairé, U. D. (1986) · Circulation · doi:10.1161/01.cir.73.6.1097 · Cited by 192 · see citing works
FAD and GSH participate in macrophage synthesis of nitric oxide
Stuehr, D. J., Kwon, N. S., & Nathan, C. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)92357-6 · Cited by 181 · see citing works
Vasoreactivity of the culprit lesion in unstable angina.
Bogaty, P. M., Hackett, D., Davies, G., & Maseri, A. (1994) · Circulation · doi:10.1161/01.cir.90.1.5 · Cited by 169 · see citing works
Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia
Gilligan, D. M., Sack, M. N., Guetta, V., Casino, P. R., Quyyumi, A. A., Rader, D. J., Panza, J. A., & Cannon, R. O. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90164-3 · Cited by 168 · see citing works
Control of shear stress in the epicardial coronary arteries of humans: Impairment by atherosclerosis
Vita, J. A., Treasure, C. B., Ganz, P., Cox, D. A., Fish, R. D., & Selwyn, A. P. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90416-6 · Cited by 117 · see citing works
Self-citation
Protection From Oxidized LDL–Induced Leukocyte Adhesion to Microvascular and Macrovascular Endothelium In Vivo by Vitamin C but Not by Vitamin E
Lehr, H., Frei, B. B., Olofsson, A. M., Carew, T. E., & Arfors, K. ‐. (1995) · Circulation · doi:10.1161/01.cir.91.5.1525 · Cited by 116 · see citing works
Self-citation
Nitric oxide production by cultured aortic endothelial cells in response to thiol depletion and replenishment.
Murphy, M. E., Piper, H. M., Watanabe, H., & Sies, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55008-0 · Cited by 109 · see citing works
Nonenzymatic Antioxidant Defense Systems
Briviba, K., & Sies, H. (1994) · Elsevier eBooks · doi:10.1016/b978-0-08-057168-3.50010-2 · Cited by 103 · see citing works
Nitric oxide synthesis is impaired in glutathione-depleted human umbilical vein endothelial cells
Ghigo, D., Alessio, P., Foco, A., Bussolino, F., Costamagna, C., Heller, R., Garbarino, G. M., Pescarmona, G., & Bosìa, A. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.3.c728 · Cited by 95 · see citing works
Relationship of Plasma Level of Vitamin C to Mortality from Ischemic Heart Disease
GEY, K. F., Stähelin, H. B., Puska, P., & Evans, A. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb23755.x · Cited by 85 · see citing works
Effect of acetylcholine on the highly stenotic coronary artery: Difference between the constrictor response of the infarct-related coronary artery and that of the noninfarct-related artery
Okumura, K., Yasue, H., Matsuyama, K., Ogawa, H., Morikami, Y., Obata, K., & Sakaino, N. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90513-m · Cited by 85 · see citing works
Correlation of cold pressor and flow-mediated brachial artery diameter responses with the presence of coronary artery disease
Corretti, M. C., Plotnick, G. D., & Vogel, R. A. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80411-1 · Cited by 72 · see citing works
Low Plasma Vitamins E and C Increased Risk of Angina in Scottish Mena
Riemersma, R. A., Wood, D. A., MacIntyre, C. C. A., Elton, R., GEY, K. F., & Oliver, M. F. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb14928.x · Cited by 65 · see citing works
Preservation of Endothelium-Dependent Relaxation in Atherosclerotic Rabbit Aorta by Probucol
Simon, B. C., Haudenschild, C. C., Cohen, R. A., & Palacino, J. J. (1993) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199306000-00007 · Cited by 59 · see citing works
Effects of selenium, vitamin E and vitamin C on human prostacyclin and thromboxane synthesis
Toivanen, J. (1987) · Prostaglandins Leukotrienes and Medicine · doi:10.1016/0262-1746(87)90036-9 · Cited by 57 · see citing works
Diet, antioxidant vitamins, oxidative stress and risk of coronary artery disease: the Peerzada Prospective Study.
Rb, S., Niaz, M. A., Bishnoi, I., Jp, S., Gupta, S., Ss, R., Singh, R., Begum, R., Chibo, H., & Shoumin, Z. (1994) · PubMed · Cited by 37 · see citing works
The Role of Thiols in the Apparent Activation of Rat Brain Nitric Oxide Synthase (NOS)1
Komori, Y., Hyun, J., Chiang, K. T., & Fukuto, J. M. (1995) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124797 · Cited by 35 · see citing works
Vitamin C increases the prostacyclin production and decreases the vascular lesions in experimental atherosclerosis in rabbits
Beetens, J. R., Coene, M. C., Verheyen, A., Zonnekeyn, L. L., & Herman, A. G. (1986) · Prostaglandins · doi:10.1016/0090-6980(86)90003-1 · Cited by 31 · see citing works

Flagged first, then by citations

Sorted by citations

Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. S., Charbonneau, F., Creager, M. A., Deanfield, J. E., Drexler, H., Gerhard‐Herman, M. D., Herrington, D. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,606 · see citing works
Self-citation
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839 · see citing works
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,611 · see citing works
Self-citation
Endothelial cells in physiology and in the pathophysiology of vascular disorders.
Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J., Zimmerman, G. A., McEver, R. P., Pober, J. S., Wick, T. M., Konkle, B. A., Schwartz, B. S., et al. (1998) · PubMed · doi:10.1182/blood.v91.10.3527 · Cited by 2,244 · see citing works
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949 · see citing works
Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease
Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961 · see citing works
Antioxidants and Atherosclerotic Heart Disease
Diaz, M. N., Frei, B. B., Vita, J. A., & Keaney, J. F. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708073370607 · Cited by 1,353 · see citing works
Self-citation
Antioxidant Capacity, Vitamin C, Phenolics, and Anthocyanins after Fresh Storage of Small Fruits
Kalt, W., Forney, C. F., Martín, A., & Prior, R. L. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990266t · Cited by 981 · see citing works
Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans
Carr, A. C., & Frei, B. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1086 · Cited by 940 · see citing works
Self-citation
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883 · see citing works
Endothelial Function and Oxidative Stress in Cardiovascular Diseases
Higashi, Y., Noma, K., Yoshizumi, M., & Kihara, Y. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-1102 · Cited by 796 · see citing works
Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial
Chappell, L. C., Seed, P. T., Briley, A. L., Kelly, F. J., Lee, R., Hunt, B. J., Parmar, K., Bewley, S., Shennan, A. H., Steer, P. J., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)80010-5 · Cited by 784 · see citing works
Risk Stratification for Postoperative Cardiovascular Events via Noninvasive Assessment of Endothelial Function
Gokce, N., Keaney, J. F., Hunter, L. M., Watkins, M. T., Menzoı́an, J. O., & Vita, J. A. (2002) · Circulation · doi:10.1161/01.cir.0000012543.55874.47 · Cited by 782 · see citing works
Self-citation
Predictive value of noninvasivelydetermined endothelial dysfunction for long-term cardiovascular events inpatients with peripheral vascular disease
Gokce, N., Keaney, J. F., Hunter, L. M., Watkins, M. T., Nedeljkovic, Z. S., Menzoı́an, J. O., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00333-4 · Cited by 776 · see citing works
Self-citation
Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activity in Essential Hypertension
Taddei, S., Virdis, A., Ghiadoni, L., Magagna, A., & Salvetti, A. (1998) · Circulation · doi:10.1161/01.cir.97.22.2222 · Cited by 757 · see citing works
Vitamin C: The known and the unknown and Goldilocks
Padayatty, S., & Levine, M. (2016) · Oral Diseases · doi:10.1111/odi.12446 · Cited by 753 · see citing works
Endothelial Dysfunction: Does It Matter? Is It Reversible?
Celermajer, D. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00189-7 · Cited by 679 · see citing works
Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility of LDL Cholesterol to Oxidation in Patients With Coronary Artery Disease
Stein, J. H., Keevil, J. G., Wiebe, D. A., Aeschlimann, S. E., & Folts, J. D. (1999) · Circulation · doi:10.1161/01.cir.100.10.1050 · Cited by 573 · see citing works
The role of nitric oxide in cardiovascular diseases
NASEEM, K. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.09.003 · Cited by 557 · see citing works
Short- and Long-Term Black Tea Consumption Reverses Endothelial Dysfunction in Patients With Coronary Artery Disease
Duffy, S. J., Keaney, J. F., HOLBROOK, M. M., Gokce, N., Swerdloff, P. L., Frei, B. B., & Vita, J. A. (2001) · Circulation · doi:10.1161/01.cir.104.2.151 · Cited by 552 · see citing works
Self-citation
Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease
Alp, N. J., & Channon, K. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000110785.96039.f6 · Cited by 524 · see citing works
Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease
Neunteufl, T., Katzenschlager, R., Hassan, A. H. M., Klaar, U., Schwarzacher, S. P., Glogar, D., Bauer, P., & Weidinger, F. F. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06018-2 · Cited by 510 · see citing works
Endothelial dysfunction: a comprehensive appraisal.
Esper, R. J., Nordaby, R. A., Vilariño, J. O., Paragano, A. J., Cacharrón, J. L., & Machado, R. A. (2006) · Cardiovascular Diabetology · doi:10.1186/1475-2840-5-4 · Cited by 493 · see citing works
Effect of Antioxidant Vitamins on the Transient Impairment of Endothelium—Dependent Brachial Artery Vasoactivity Following a Single High-Fat Meal
Plotnick, G. D. (1997) · JAMA · doi:10.1001/jama.1997.03550200058032 · Cited by 469 · see citing works
Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis
Heinecke, J. W. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00173-7 · Cited by 466 · see citing works
Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis
Kawashima, S., & Yokoyama, M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000125114.88079.96 · Cited by 455 · see citing works
Assessment and treatment of endothelial dysfunction in humans
Anderson, T. J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00259-4 · Cited by 443 · see citing works
Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
Schulz, E., Jansen, T., Wenzel, P., Daiber, A., & Münzel, T. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1989 · Cited by 430 · see citing works
THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE
Dudzinski, D. M., Igarashi, J., Greif, D. M., & Michel, T. M. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121844 · Cited by 425 · see citing works
l-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin
Heller, R., Unbehaun, A., Schellenberg, B., Mayer, B., Werner‐Felmayer, G., & Werner, E. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004392200 · Cited by 421 · see citing works
Role of Oxidant Stress in Endothelial Dysfunction Produced by Experimental Hyperhomocyst(e)inemia in Humans
Kanani, P. M., Sinkey, C. A., Browning, R. L., Allaman, M. M., Knapp, H. R., & Haynes, W. G. (1999) · Circulation · doi:10.1161/01.cir.100.11.1161 · Cited by 418 · see citing works
Vascular Consequences of Endothelial Nitric Oxide Synthase Uncoupling for the Activity and Expression of the Soluble Guanylyl Cyclase and the cGMP-Dependent Protein Kinase
Münzel, T. F., Daiber, A., Ullrich, V., & Mülsch, A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000168896.64927.bb · Cited by 409 · see citing works
Nitric Oxide and the Vascular Endothelium
Moncada, S., & Higgs, E. A. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6_7 · Cited by 408 · see citing works
Endothelial function in health and disease: new insights into the genesis of cardiovascular disease
Quyyumi, A. A. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00209-5 · Cited by 405 · see citing works
Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations
Jackson, T. S., Xu, A., Vita, J. A., & Keaney, J. F. (1998) · Circulation Research · doi:10.1161/01.res.83.9.916 · Cited by 400 · see citing works
Self-citation
Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction
Münzel, T. F., Sinning, C., Post, F., Warnholtz, A., & Schulz, E. (2008) · Annals of Medicine · doi:10.1080/07853890701854702 · Cited by 399 · see citing works
Vitamin C Improves Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure
Hornig, B., Arakawa, N., Kohler, C., & Drexler, H. (1998) · Circulation · doi:10.1161/01.cir.97.4.363 · Cited by 389 · see citing works
Glycemic index in chronic disease: a review
Augustin, L. S. A., Franceschi, S., Jenkins, D., Kendall, C. W. C., & Vecchia, C. L. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601454 · Cited by 387 · see citing works
Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease
Gokce, N., Keaney, J. F., Frei, B., Holbrook, M., Olesiak, M., Zachariah, B. J., Leeuwenburgh, C., Heinecke, J. W., & Vita, J. A. (1999) · Circulation · doi:10.1161/01.cir.99.25.3234 · Cited by 387 · see citing works
Self-citation
Redox Control of Endothelial Function and Dysfunction: Molecular Mechanisms and Therapeutic Opportunities
Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383 · see citing works
Endothelial permeability, LDL deposition, and cardiovascular risk factors—a review
Mundi, S., Massaro, M., Scoditti, E., Carluccio, M. A., van Hinsbergh, V. W. M., Iruela-Arispe, M. L., & De Caterina, R. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx226 · Cited by 367 · see citing works
Ascorbic Acid Enhances Endothelial Nitric-oxide Synthase Activity by Increasing Intracellular Tetrahydrobiopterin
Huang, A., Vita, J. A., Venema, R. C., & Keaney, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002248200 · Cited by 365 · see citing works
Self-citation
Vitamin C Improves Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans With Hypercholesterolemia
Ting, H. H., Timimi, F. K., Haley, E. A., Roddy, M.-A., Ganz, P., & Creager, M. A. (1997) · Circulation · doi:10.1161/01.cir.95.12.2617 · Cited by 355 · see citing works
Role of nitric oxide in cardiovascular disease: focus on the endothelium
Cannon, R. O. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.8.1809 · Cited by 346 · see citing works
Nitrite‐derived nitric oxide: a possible mediator of ‘acidic–metabolic’ vasodilation
Modin, A., Björne, H., Herulf, M., Alving, K., Weitzberg, E., & Lundberg, J. O. N. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00771.x · Cited by 346 · see citing works
Effect of acute and chronic ascorbic acid on flow‐mediated dilatation with sedentary and physically active human ageing
Eskurza, I., Monahan, K. D., Robinson, J. A., & Seals, D. R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.057042 · Cited by 341 · see citing works
Comparative Effect of ACE Inhibition and Angiotensin II Type 1 Receptor Antagonism on Bioavailability of Nitric Oxide in Patients With Coronary Artery Disease
Hornig, B., Landmesser, U., Kohler, C., Ahlersmann, D., Spiekermann, S., Christoph, A., Tatge, H., & Drexler, H. (2001) · Circulation · doi:10.1161/01.cir.103.6.799 · Cited by 341 · see citing works
Blood Letting in High-Ferritin Type 2 Diabetes
Fernández‐Real, J. M., Peñarroja, G., Castro, A., Garcia-Bragado, F., Hernández‐Aguado, I., & Ricart, W. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1000 · Cited by 333 · see citing works
Total Phenolic Compounds, Flavonoids, and Radical Scavenging Activity of 21 Selected Tropical Plants
Mustafa, R. A., Hamid, A. A., Mohamed, S., & Bakar, F. A. (2009) · Journal of Food Science · doi:10.1111/j.1750-3841.2009.01401.x · Cited by 322 · see citing works
Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis
Wannamethee, S. G., Lowe, G. D. O., Rumley, A., Bruckdorfer, K. R., & Whincup, P. H. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.83.3.567 · Cited by 317 · see citing works
Ascorbic Acid Prevents Contrast-Mediated Nephropathy in Patients With Renal Dysfunction Undergoing Coronary Angiography or Intervention
Spargias, K. S., Alexopoulos, E., Kyrzopoulos, S., Iacovis, P., Greenwood, D. C., Manginas, A., Voudris, V. A., Pavlides, G., Buller, C. E. H., Kremastinos, D. T., et al. (2004) · Circulation · doi:10.1161/01.cir.0000146396.19081.73 · Cited by 318 · see citing works
Folic acid improves arterial endothelial function in adults with hyperhomocystinemia
Woo, K. S., Chook, P., Lolin, Y. I., Sanderson, J. E., Metreweli, C., & Celermajer, D. S. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00469-6 · Cited by 303 · see citing works
Electron Spin Resonance Characterization of Vascular Xanthine and NAD(P)H Oxidase Activity in Patients With Coronary Artery Disease
Spiekermann, S., Landmesser, U., Dikalov, S., Bredt, M., Gamez, G., Tatge, H., Reepschläger, N., Hornig, B., Drexler, H., & Harrison, D. G. (2003) · Circulation · doi:10.1161/01.cir.0000056762.69302.46 · Cited by 298 · see citing works
Long-Term Vitamin C Treatment Increases Vascular Tetrahydrobiopterin Levels and Nitric Oxide Synthase Activity
d’Uscio, L. V., Milstien, S., Richardson, D. M., Smith, L., & Katušić, Z. S. (2003) · Circulation Research · doi:10.1161/01.res.0000049166.33035.62 · Cited by 297 · see citing works
Surrogate Markers for Cardiovascular Disease
Cohn, J. N., Quyyumi, A. A., Hollenberg, N. K., & Jamerson, K. (2004) · Circulation · doi:10.1161/01.cir.0000133442.99186.39 · Cited by 284 · see citing works
Vitamin C Improves Endothelial Dysfunction of Epicardial Coronary Arteries in Hypertensive Patients
Solzbach, U., Hornig, B., Jeserich, M., & Just, H. (1997) · Circulation · doi:10.1161/01.cir.96.5.1513 · Cited by 278 · see citing works
The role of virgin olive oil components in the modulation of endothelial function
Perona, J. S., Cabello-Moruno, R., & Ruíz-Gutiérrez, V. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.11.007 · Cited by 278 · see citing works
Research Methods in Human Cardiovascular Pharmacology edited by Dr S. Maxwell and Prof. D. Webb Flow‐mediated dilatation
Raitakari, O. T., & Celermajer, D. S. (2000) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2000.00277.x · Cited by 272 · see citing works
Biological Significance of Ascorbic Acid (Vitamin C) in Human Health - A Review
Iqbal, K., Khan, A., & Khan Khattak, M. M. A. (2003) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2004.5.13 · Cited by 270 · see citing works
“…severity of illnesses (Hemila, 1992). breast, cervix, colon, rectum, esophagus, larynx, lung, Gaby and Singh (1991) reports that in 1981, in one mouth, prostate and stomach (Levine, 1996; Block, study, when 1 g of vitamin C was given intravenously to 1992; Frei, 1994; Block, 1991; Jacobs, 1993).”
BackgroundInfluential
Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction
Lamas, G. A., Goertz, C., Boineau, R., Mark, D. B., Rozema, T. C., Nahin, R. L., Lindblad, L., Lewis, E. F., Drisko, J., Lee, K. L., et al. (2013) · JAMA · doi:10.1001/jama.2013.2107 · Cited by 269 · see citing works
Antioxidants, diabetes and endothelial dysfunction
Laight, D. W. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00054-7 · Cited by 264 · see citing works
Antiobesity pharmacotherapy in the management of Type 2 diabetes
Scheen, A. J., & Lef�bvre, P. J. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/(sici)1520-7560(200003/04)16:2 · Cited by 29 · see citing works
Endothelial dysfunction and hypertension in aging
Higashi, Y., Kihara, Y., & Noma, K. (2012) · Hypertension Research · doi:10.1038/hr.2012.138 · Cited by 265 · see citing works
How does ascorbic acid prevent endothelial dysfunction?
May, J. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00269-0 · Cited by 260 · see citing works
Endothelial function, inflammation, and prognosis in cardiovascular disease
Gonzalez, M. A., & Selwyn, A. P. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.09.016 · Cited by 258 · see citing works
Coronary risk factors, endothelial function, and atherosclerosis: A review
Vogel, R. A. (1997) · Clinical Cardiology · doi:10.1002/clc.4960200505 · Cited by 257 · see citing works
Vascular Extracellular Superoxide Dismutase Activity in Patients With Coronary Artery Disease
Landmesser, U., Merten, R., Spiekermann, S., Büttner, K., Drexler, H., & Hornig, B. (2000) · Circulation · doi:10.1161/01.cir.101.19.2264 · Cited by 255 · see citing works
Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial
Engler, M. M., Engler, M. B., Malloy, M. J., Chiu, E. Y., Schloetter, M. C., Paul, S. M., Stuehlinger, M., Lin, K. Y., Cooke, J. P., Morrow, J. D., et al. (2003) · Circulation · doi:10.1161/01.cir.0000086345.09861.a0 · Cited by 253 · see citing works
Improving public health?: The role of antioxidant-rich fruit and vegetable beverages
Wootton-Beard, P. C., & Ryan, L. (2011) · Food Research International · doi:10.1016/j.foodres.2011.09.015 · Cited by 251 · see citing works
Chronic heart failure and micronutrients
Witte, K. K., Clark, A. L., & Cleland, J. G. F. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01227-x · Cited by 237 · see citing works
l-Ascorbic Acid Potentiates Nitric Oxide Synthesis in Endothelial Cells
Heller, R., Münscher-Paulig, F., Gräbner, R., & Till, U. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8254 · Cited by 224 · see citing works
Reassessing the cardiac risk profile in chronic hemodialysis patients
Becker, B. N., Himmelfarb, J., Henrich, W., & Hakim, R. M. (1997) · Journal of the American Society of Nephrology · doi:10.1681/asn.v83475 · Cited by 225 · see citing works
Glutathione is implied in the control of 7‐ketocholesterol‐induced apoptosis, which is associated with radical oxygen species production
Lizard, G., Gueldry, S., Sordet, O., Monier, S., Athias, A., Miguet‐Alfonsi, C., Bessède, G., Barrère‐Lemaire, S., Solary, É., & Gambert, P. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.15.1651 · Cited by 216 · see citing works
Angiotensin II Induces Endothelial Xanthine Oxidase Activation: Role for Endothelial Dysfunction in Patients With Coronary Disease
Landmesser, U., Spiekermann, S., Preuss, C., Sorrentino, S., Fischer, D., Manes, C., Mueller, M., & Drexler, H. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000258415.32883.bf · Cited by 210 · see citing works
Nutraceuticals, Vitamins, Antioxidants, and Minerals in the Prevention and Treatment of Hypertension
Houston, M. C. (2005) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.01.004 · Cited by 208 · see citing works
Contrast agents and renal cell apoptosis
Romano, G., Briguori, C., Quintavalle, C., Zanca, C., Rivera, N. V., Colombo, A., & Condorelli, G. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn197 · Cited by 210 · see citing works
Absorption, transport, and disposition of ascorbic acid in humans
Rumsey, S. C., & Levine, M. (1998) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(98)00002-3 · Cited by 210 · see citing works
Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
Schmidt, T. S., & Alp, N. J. (2007) · Clinical Science · doi:10.1042/cs20070108 · Cited by 195 · see citing works
Brugada syndrome: 1992–2002
Antzelevitch, C. N., Brugada, P., Brugada, J., Brugada, R., Towbin, J. A., & Nademanee, K. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00310-3 · Cited by 191 · see citing works
Effects of high intensity pulsed electric field processing conditions on vitamin C and antioxidant capacity of orange juice and gazpacho, a cold vegetable soup
Elez‐Martínez, P., & Martín‐Belloso, O. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.04.048 · Cited by 192 · see citing works
The Role of Natural Antioxidants in Preserving the Biological Activity of Endothelium-Derived Nitric Oxide
Carr, A., & Frei, B. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00225-2 · Cited by 190 · see citing works
Self-citation
Brachial Flow-Mediated Vasodilator Responses in Population-Based Research: Methods, Reproducibility and Effects of Age, Gender and Baseline Diameter
Herrington, D. M., Fan, L., Drum, M., Riley, W. A., Pusser, B. E., Crouse, J. R., Burke, G. L., McBurnie, M. A., Morgan, T. M., & Espeland, M. A. (2001) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182670100800512 · Cited by 187 · see citing works
Nutraceutical therapies for atherosclerosis
Moss, J. W. E., & Ramji, D. P. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.103 · Cited by 186 · see citing works
Antioxidants in Cardiovascular Therapy: Panacea or False Hope?
Goszcz, K., Deakin, S. J., Duthie, G. G., Stewart, D., Leslie, S. J., & Megson, I. L. (2015) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2015.00029 · Cited by 184 · see citing works
Prognostic value of endothelial function
Quyyumi, A. A. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00430-2 · Cited by 182 · see citing works
Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms
Pfeuffer, M., Auinger, A., Bley, U., Kraus-Stojanowic, I., Laue, C., Winkler, P., Rüfer, C. E., Frank, J., Boesch‐Saadatmandi, C., Rimbach, G. H., et al. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.08.010 · Cited by 182 · see citing works
High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance
Chen, H., Karne, R. J., Hall, G., Campia, U., Panza, J. A., Cannon, R. O., Wang, Y., Katz, A., Levine, M., & Quon, M. J. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00768.2005 · Cited by 178 · see citing works
Improvement in endothelial function by angiotensin-converting enzyme inhibition in non–insulin-dependent diabetes mellitus
O’Driscoll, G., GREEN, D. J., Maiorana, A., Stanton, K. G., Colreavy, F. B., & Taylor, R. R. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00065-0 · Cited by 173 · see citing works
Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina
Motoyama, T., Kawano, H., Kugiyama, K., Hirashima, O., Ohgushi, M., Tsunoda, R., Moriyama, Y., Miyao, Y., Yoshimura, M., Ogawa, H., et al. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00447-1 · Cited by 170 · see citing works
Regular ingestion of black tea improves brachial artery vasodilator function
Hodgson, J. M., Puddey, I. B., Burke, V., Watts, G. F., & Beilin, L. J. (2002) · Clinical Science · doi:10.1042/cs20010120 · Cited by 170 · see citing works
Edaravone (3-Methyl-1-Phenyl-2-Pyrazolin-5-one), A Novel Free Radical Scavenger, for Treatment of Cardiovascular Diseases
Higashi, Y., Jitsuiki, D., Chayama, K., & Yoshizumi, M. (2006) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/157489006775244191 · Cited by 165 · see citing works
Androgen Deprivation Is Associated With Enhanced Endothelium-Dependent Dilatation in Adult Men
Herman, S. M., Robinson, J. T. C., McCredie, R. J., Adams, M. R., Boyer, M. J., & Celermajer, D. S. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2004 · Cited by 165 · see citing works
Angiostatin Inhibits Coronary Angiogenesis During Impaired Production of Nitric Oxide
Matsunaga, T., Weihrauch, D., Moniz, M., Tessmer, J. P., Warltier, D. C., & Chilian, W. M. (2002) · Circulation · doi:10.1161/01.cir.0000015856.84385.e9 · Cited by 163 · see citing works
Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans?
Frei, B. B., Birlouez‐Aragon, I., & Lykkesfeldt, J. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.649149 · Cited by 164 · see citing works
Self-citation
Cigarette Smoking Is Associated With Increased Human Monocyte Adhesion to Endothelial Cells: Reversibility With Oral l-Arginine but Not Vitamin C
Adams, M. R., Jessup, W., & Celermajer, D. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00537-2 · Cited by 162 · see citing works
Cholesterol lowering and endothelial function
Vogel, R. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00261-2 · Cited by 162 · see citing works
Smoking and endothelial function
Puranik, R., & Celermajer, D. S. (2003) · Progress in Cardiovascular Diseases · doi:10.1053/pcad.2003.ypcad13 · Cited by 157 · see citing works
Pharmacological Concentrations of Ascorbic Acid Are Required for the Beneficial Effect on Endothelial Vasomotor Function in Hypertension
Sherman, D. L., Keaney, J. F., Biegelsen, E. S., Duffy, S. J., Coffman, J. D., & Vita, J. A. (2000) · Hypertension · doi:10.1161/01.hyp.35.4.936 · Cited by 158 · see citing works
Self-citation

Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease
Gokce, N., Keaney, J. F., Frei, B., Holbrook, M., Olesiak, M., Zachariah, B. J., Leeuwenburgh, C., Heinecke, J. W., & Vita, J. A. (1999) · Circulation · doi:10.1161/01.cir.99.25.3234 · Cited by 387 · see citing works
Self-citation
Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid
Widlansky, M. E., Biegelsen, E. S., Hamburg, N. M., Duffy, S. J., Keaney, J. F., & Vita, J. A. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.016 · Cited by 10 · see citing works
Self-citation
Central receiving office for all FRBM manuscripts
(2004) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00834-7
Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension
Duffy, S. J., Gokce, N., HOLBROOK, M. M., Hunter, L. M., Biegelsen, E. S., Huang, A., Keaney, J. F., & Vita, J. A. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h528 · Cited by 118 · see citing works
Self-citation
Ascorbic Acid and Endothelial NO Synthesis
Packer, L. (2003) · AOCS Publishing eBooks · doi:10.4324/9780429270710-5 · Cited by 4 · see citing works

Authors: Levine, G. N., Frei, B., Koulouris, S. N., Gerhard, M. D., Keaney, J. F., & Vita, J. A.
Affiliations: Boston University (US)
ORCID: Levine, Glenn N.
Keaney, John F.
Vita, Joseph A.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-03-15
Volume: 93
Issue: 6
Pages: 1107-1113
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.93.6.1107
OpenAlex: W2035433779
Cited by: 582
References: 53
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 12 · 2018: 8 · 2017: 12 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 14 · 2012: 12
FWCI: 34.16
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: National Institutes of Health (1f32hl008635-01, 7r29hl049954-05, 1r01hl053398-01a1)
National Heart, Lung, and Blood Institute (HL 53398, HL-08635, HL49954)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: vitamin C, endothelial dysfunction, endothelium-dependent vasodilation, coronary artery disease, oxidative stress, antioxidant therapy, brachial artery, atherosclerosis, hyperemic flow
MeSH terms: Adult, Aged, Aged, 80 and over, Antioxidants, Ascorbic Acid, Coronary Circulation, Coronary Disease, Endothelium, Vascular, Female, Humans, Male, Middle Aged, Nitric Oxide, Vasodilation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks